GIT Drug

Question 1

Name 2 Chelates

Answer 1

Bismuth Chelate , Sucralfate

Question 2

MOA of Chelate

Answer 2

1. Binds to Ulcer base
2. Inhibition of pepsin
3. Promote synthesis of prostaglandin
4. Stimulate bicarbonate secretion

Question 3

MOA of misoprostol

Answer 3

• Imitates action of endogenous prostaglandin -> maintained integrity of gastroduodenal mucosal barrier
• promotes healing

Question 4

Contra for Misoprostol

Answer 4

Preggo, breastfeeding women, hypotensive patient

Question 5

Name 2 antacids

Answer 5

Aluminium hydroxide , magnesium hydroxide

Question 6

MOA of antacids

Answer 6

•raise luminal pH of stomach
• neutralized gastric acid
• bind and inactivate pepsin

Question 7

Adverse effect of Aluminium hydroxide

Answer 7

Constipation, Hypophosphatemia, Osteodysthrophy, Proximal muscle weakness, Seizures

Mnemonic : CHOPS

Question 8

Adverse effect of magnesium hydroxide

Answer 8

Cardiac arrest , diarrhoea, hyporeflexia , hypotension

Question 9

MOA of Loperamide

Answer 9

• mu- opoid receptor agonist
- slows down gut motility

Question 10

Adverse effect of loperamide

Answer 10

Constipation and nausea

Question 11

Drug class of Ondansetron

Answer 11

Antiemetic

Question 12

MOA of Ondasetron

Answer 12

5HT3 antagonist -> decreased vagal stimulation

Question 13

Adverse effect of Ondasetron

Answer 13

•Headache,constipation
•QT interval prolongation
•Serotonin Syndrome

Question 14

Adverse effect of Ondasetron

Answer 14

•Headache,constipation
•QT interval prolongation
•Serotonin Syndrome