gi tract conditions Flashcards

1
Q

what is gastro-esophageal reflux? (acid reflux)

A

a condition in which stomach acid repeatedly flows back up into the tube connecting the mouth and stomach, called the esophagus. It’s often called GERD for short. This backwash is known as acid reflux, and it can irritate the lining of the esophagus.

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2
Q

what are symptoms of acid reflux?

A

A burning sensation in the chest, often called heartburn. Heartburn usually happens after eating and might be worse at night or while lying down.
Backwash of food or sour liquid in the throat.
Upper belly or chest pain.
Trouble swallowing, called dysphagia.
Sensation of a lump in the throat.

If you have nighttime acid reflux, you also might experience:

An ongoing cough.
Inflammation of the vocal cords, known as laryngitis.
New or worsening asthma.

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3
Q

what causes acid reflux?

A

when the sphincter at the bottom of the esophagus doesnt relax, stomach acid can flow back into the esophagus. this can cause the esophagus to become inflammed

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4
Q

what are some conditions which can increase the risk of acid reflux?

A

obesity,
bulging of the top of the stomach above the diaphragm (hital hernia)
pregnancy
connective tissue dissorders such as scleroderma
delayed stomach emptying

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5
Q

what are factors which can aggravate acid reflux?

A

Smoking.
Eating large meals or eating late at night.
Eating certain foods, such as fatty or fried foods.
Drinking certain beverages, such as alcohol or coffee.
Taking certain medicines, such as aspirin.

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6
Q

what treatments are used for acid reflux?

A

Prescription-strength proton pump inhibitors (PPIs) work by inhibiting certain stomach cells from “pumping” acid into the stomach

H2 blockers which provide relief from indigestion, stomach pain, heart burn and reflux, nausea and vomiting and sour stomach

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7
Q

what is Mallory Weiss tear?

A

a split in the inner layer of your esophagus caused by forceful vomiting, retching or straining- causing bleeding. occur near where the esophagus meets the stomach

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8
Q

what are symptoms of mallory weiss tears?

A

the most common symptom is vomiting blood
other symptoms are:
dark sticky tools,
dizziness,
fainting.

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9
Q

what are the complications of mallory weiss tars?

A

if untreated can cause:
amnemia (deficiency of healthy red blood cells), fatigue and shortness of breath, dizziness, abdominal or chest pain.

If the tear is severe and internal bleeding occurs, you may experience symptoms of shock such as:

Anxiety or agitation.
Dry mouth or thirst.
Nausea.
Pale, cold and clammy skin.
Rapid heartbeat or heart palpitations.

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10
Q

what is the treatment of mallory weis tears?

A

h2 receptor blockers-which provide relief from indigestion, stomach pain, heart burn and reflux, nausea and vomiting and sour stomach

proton pump inhibitors- Decrease stomach acid production
Relieve symptoms of chronic acid reflux (GERD) and stomach ulcers

Self limiting in 80-90% of cases (stop bleeding and heal on its own)
injection or a heat treatment to stop bleeding
Surgical repair (rare)

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11
Q

what is the diagnosis of mallory weiss tear?

A

sign & symptoms
stool test
upper GI endoscopy

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12
Q

what is hiatus hernia?

A

A hiatus Hernia is when part of the stomach moves up through a small opening (hiatus) in the diaphragm into the chest.
A hernia is when any organ or tissue pushes through a weakness in the tissue barrier that normally contains it.

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13
Q

what are the 4 types of hital hernias?

A

type 1- mst common. the part of your esophagus that connects to your stomach slides up through the widened hiatus at times and then slides back down.

type 2-the upper part of your stomach pushes up through the hiatus alongside your esophagus, forming a bulge next to it. This is also called a rolling hiatal hernia.

type 3- mix of type 1 and 2.The part of your esophagus that connects to your stomach — the gastroesophageal junction — slides up through the hiatus at times. And another part of your stomach also bulges through, alongside the gastroesophageal junction at times.

type 4-The hernia involves your stomach together with another abdominal organ, such as one of your intestines, your pancreas or your spleen.

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14
Q

what are the risk factors of a hiatus hernia?

A

age-related changes in diaphragm (common over 50)

pregnancy

obesity

exercising and heavy weight lifting

persistence and intense pressure on surrounding muscles caused by severe coughing, vomiting, straining during the bowel movement

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15
Q

what are the signs and symptoms of hiatus hernia?

A

Heartburn (GORD) (painful burning sensation in the chest often after eating) due to acid reflux

shortness of breath

regurgitation of food or liquid into mouth

burping and feel bloated

feeling full soon after eat

nausea and vomiting

dysphagia (difficulty swallowing)

vomiting of blood or passing of black stool

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16
Q

what is the treatment of hiatus hernia?

A

life style changes
- change eating habits
- avoid lying down at least 3 hours after eating or drinking
- stop smoking

teating GORD symptoms
keyhole surgery (laparoscopy) in severe cases (in case of paraoseophageal hernia

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17
Q

what is the diagnosis of hiatus hernia?

A

xray, endoscopy

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18
Q

what is achlorhydria?

A

reduction in stomach acid and pepsinogen secretion.

It’s a more severe form of a hypochlorhydria, a deficiency of stomach acids. Both conditions can impair the digestive process and lead to damage of the gastrointestinal system. Without stomach acid, your body won’t properly break down protein.

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19
Q

what are symptoms of achlorhydria?

A

iron deficiency anemia- without stomach acids the body will have issues absorbing iron
abdominal bloating
indigestion
nausea
acid reflux
digestive issues
diarrhea
weak, brittle nails
hair loss
undigested food in stools

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20
Q

what are the causes of achlorhydria?

A

gastric muscosal atrophic- the process of chronic inflammation of the gastric mucosa of the stomach.
hypothryoidism- slows down your metabolism, resulting in a decrease of gastric acid production.

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21
Q

what are the treatments from achlorhydria?

A

infection- antibiotics
nurtitional supplements.

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22
Q

what are peptic ulcers?

A

open sores on the inner lining of the stomach and upper part of the small intestine.
peptic ulcers include:
Gastric ulcers, which appear on the inside of the stomach.
Duodenal ulcers, which appear on the inside of the upper part of the small intestine, called the duodenum.

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23
Q

what are the symptoms of peptic ulcers?

A

Dull or burning stomach pain. For some people, pain may be worse between meals and at night. For others, it may be worse after eating.
Feeling of fullness or bloating.
Belching.
Heartburn.
Nausea.

peptic ulcers can cause bleeding from the ulcer the symptoms may include:
vommiting blood,
having dark blood in stools,
feeling dizzy or fainting

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24
Q

what are the causes of peptic ulcers?

A

Peptic ulcers happen when acid in the organs that food travels through, called the digestive tract, eats away at the inner surface of the stomach or small intestine.

helicobacter pylori- a germ living in the mucous layer that covers and protects tissues that line the stomach and small intestine.can cause swelling and irritation, called inflammation, of the stomach’s inner layer. When this happens, it can cause an ulcer.

regular use of certain pain relievers: taking asprin or anti flammatory drugs can irrate or infame the lining of the stomach and small inestine

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25
Q

what are complications of a peptic ulcer?

A

bleeding in the stomach or duodenum,
a hole called a perforation in the stomach wall,
blockage,
stomach cancer

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26
Q

what are treatments used for peptic ulcers?

A

antibiotics to kill h pylori,
medicanes that block acid, (Acid blockers, also called histamine (H-2) blockers, help relieve ulcer pain and help with healing.)
medicanes to reduce stomach acid, (PPIs allow the petic ulcers to heal)
Medicines that protect the lining of the stomach and small intestine.

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27
Q

what is gastroparesis?

A

Gastroparesis is a condition in which the muscles in the stomach don’t move food as they should for it to be digested.

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28
Q

what are the symptoms of gastroparesis?

A

Vomiting.
Nausea.
Belly bloating.
Belly pain.
Feeling full after eating just a few bites and long after eating a meal.
Vomiting undigested food eaten a few hours earlier.
Acid reflux.
Changes in blood sugar levels.
Not wanting to eat.
Weight loss and not getting enough nutrients, called malnutrition.

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29
Q

what causes gastroparesis?

A

not always clear but sometimes damage to a nerve that controls the stomach muscles can cause it- vagus nerve

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30
Q

what are the risk factors of gastropariesis?

A

Diabetes.
Surgery on the stomach area or on the tube that connects the throat to the stomach, called the esophagus.
Infection with a virus.
Certain cancers and cancer treatments, such as radiation therapy to the chest or stomach.
Certain medicines that slow the rate of stomach emptying, such as opioid pain medicines.
A condition that causes the skin to harden and tighten, called scleroderma.
Nervous system diseases, such as migraine, Parkinson’s disease or multiple sclerosis.
Underactive thyroid, also called hypothyroidism.

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31
Q

what are the complications of gastroparesis?

A

loss of body fluids- dehydration due to vommiting
malnutrition
food that doesnt digest that hardens and stays in the stomach,
blood sugar changes

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32
Q

what is the treatment of gastroparesis?

A

changes to your diet,
medications to help the stomach muscles work (Metoclopramide).
medicines to control nausea and vomiting.
feeding tube through the nose or mouth directly into the small intestine

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33
Q

how is gastroparesis diagnosed?

A

Gastric Emptying Study (GES) using radioactive material traced by a scanner
Upper endoscopy
Barium x-rays
Wireless motility capsules (SmartPill)

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34
Q

what is jaundice?
why does it happen

A

when your skin and the whites of your eyes (mucous membranes) turn yellow.
this is when the liver is unable to process bilirubin (a yellow substance made when red blood cells break down) in your blood. caused byy too much red blood cell breakdown or liver injury.

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35
Q

what causes jandice?

A

prehapatic jaundice- to much red blood cell breakdown take over your livers ability to filter out bilirubin from your blood.

hepatic jaundice- during the production of bilirubin. This type happens when your liver can’t remove enough bilirubin from your blood. Hepatic jaundice can happen if you have liver failure.

posthepatic jaundice-Also called obstructive jaundice, this type happens when a blockage stops bilirubin from draining into your bile ducts.

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36
Q

what are the causes of prehepatic jaundice?

A

,Breaking down a large hematoma (bruise, A pool of mostly clotted blood that forms in an organ, tissue, or body space) and then reabsorbing it back into your bloodstream.
Hemolytic anemias (when blood cells are destroyed and removed from the bloodstream before their normal lifespan is over).

37
Q

what are hepatic jaundice causes?

A

Viruses, including hepatitis A, chronic hepatitis B and C, and Epstein-Barr virus infection (infectious mononucleosis).
Alcohol-induced hepatitis.
Autoimmune disorders.
Rare genetic metabolic defects.
Medicines, including penicillin, oral contraceptives, chlorpromazine (Thorazine R), estrogenic or anabolic steroids and acetaminophen toxicity.

38
Q

what are posthepatic jaundice causes?

A

Gallstones.
Inflammation (swelling) of your gallbladder.
Gallbladder cancer.
Pancreatic tumor.

39
Q

what are symptoms of jaundice?

A

Yellowish tint to your skin and the whites of your eyes.
Fever.
Chills.
Pain in your belly.
Flu-like symptoms.
Dark-colored pee.
Pale-colored poop.
Being tired or confused.
Itchy skin.
Weight loss.

40
Q

what is cirrhosis?

A

severe scaring of the liver.be caused by many forms of liver diseases and conditions, such as hepatitis or chronic alcoholism.

41
Q

what are the symptoms of cirrhosis?

A

often no symptoms until the liver damage is severe. Fatigue.
Easily bleeding or bruising.
Loss of appetite.
Nausea.
Swelling in the legs, feet or ankles, called edema.
Weight loss.
Itchy skin.
Yellow discoloration in the skin and eyes, called jaundice.
Fluid accumulation in the abdomen, called ascites (uh-SAHY-teez).
Spiderlike blood vessels on the skin.
Redness in the palms of the hands.
Pale fingernails, especially the thumb and index finger.
Clubbing of the fingers, in which the fingertips spread out and become rounder than usual.
For women, absence of or loss of periods not related to menopause.
For men, loss of sex drive, testicular shrinkage or breast enlargement, known as gynecomastia.
Confusion, drowsiness or slurred speech.

42
Q

what are the causes of cirrhosis?

A

Long-term alcohol abuse.
Ongoing viral hepatitis (hepatitis B, C and D).
Nonalcoholic fatty liver disease, a condition in which fat accumulates in the liver.
Hemochromatosis, a condition that causes iron buildup in the body.
Autoimmune hepatitis, which is a liver disease caused by the body’s immune system.
Destruction of the bile ducts caused by primary biliary cholangitis.
Hardening and scarring of the bile ducts caused by primary sclerosing cholangitis.
Wilson’s disease, a condition in which copper accumulates in the liver.
Cystic fibrosis.
Alpha-1 antitrypsin deficiency.
Poorly formed bile ducts, a condition known as biliary atresia.
Inherited disorders of sugar metabolism, such as galactosemia or glycogen storage disease.
Alagille syndrome, a genetic digestive disorder.
Infection, such as syphilis or brucellosis.
Medications, including methotrexate or isoniazid.

43
Q

what are the 3 stages of alcohol liver disease?

A

alcoholic fatty liver disease (first stage) where fat starts to accumulate around the liver.

acute alcoholic hepatitis: causes inflammation (swelling) of the liver in this stage. the outcome depends on the severity of damage.

alcoholic cirrhosis- liver is scared from alcohol abuse and can lead to liver failure.

44
Q

what are symptoms of ARLD?

A

nausea
loss of appetite
jaundice
fatigue
abdominal discomfort
increased thirst
swelling in the legs and abdomen
weight loss
darkening or lightening of the skin
red hands or feet
dark bowel movements

45
Q

whats the diagnosis and treatment for ARLD?

A

liver function test,
ct scan,
abdominal ultra sound,
liver biopsy.

NA to help stop drinking,
multivitamins,
liver transplant,
vitamin a supplements.

46
Q

what are gallstones?

A

hardened deposits of digestive fluid that can form in your gall bladder.

47
Q

what are symptoms of gall stones?

A

Sudden and rapidly intensifying pain in the upper right portion of your abdomen
Sudden and rapidly intensifying pain in the center of your abdomen, just below your breastbone
Back pain between your shoulder blades
Pain in your right shoulder
Nausea or vomiting

48
Q

what are the causes of gallstones?

A

the bile containing to much cholesterol,
the bile containing to much bilirubin,
the gall bladder doesnt empty correctly

49
Q

what is the diagnosis and treatment of gallstones?

A

abdominal ultrasound,
endoscopin ultrasound
other imaging tests- CT
blood tests

surgery to move the gallbladder,
medications to dissolve gallstones- which dont contain calcium.
Endoscopic retrograde cholangio-pancreatography (ERCP) which removes gallstones from bile ducts

50
Q

what is acute pacreatitis?

A

inflammation of the pancreas. it occurs suddenly and causes pain in the upper abdominal region. the pain often radiates to your back.

51
Q

what are the causes of acute pancreatitis?

direct and indirect

A

direct causes:
sudden immune system attacks on the pancreas, or autoimmune pancreatitis
pancreatic or gallbladder damage from surgery or injury
excessive fats called triglycerides in your blood.

indirect causes:
alcohol abuse,
cystic fibrosis, a serious condition that affects your lungs, liver, and pancreas
Kawasaki disease, a disease that occurs in children younger than 5 years old
viral infections like mumps and bacterial infections like mycoplasma
Reye’s syndrome, a complication from certain viruses that can also affect the liver
certain medications containing estrogen, corticosteroids, or certain antibiotics

52
Q

what are symptoms of acute pancreatisis?

A

pain within minutes of drinking or eating food
pain spreading from your abdomen to your back or left shoulder blade area
pain that lasts for several days at a time
pain when you lie on your back, more so than when sitting up

fever
nausea
vomiting
sweating
jaundice (yellowing of the skin)
diarrhea
bloating

53
Q

what is the diagnosis and treatment of acute pancreatitis?

A

blood tests looking for:
increased lipase, amylase level
increased alkaline phosphatase level
increased bilirubin level
increased WBC count
hypocalcaemia

and scans- ultrasound, CT, MRI.

fluids, medication for pain, removal of the gall blader

54
Q

how does biliary obstruction cause acute pancreatitis?

A

Presence of stone in the common bile duct or sphincter of Oddi
Causes bile and pancreatic juice to mix and backflow into pancreatic tissue
This causes inactive proteases to become activated and start of the auto-digestion of pancreatic tissue
Auto-digestion leads to oedema and ischemic injury to the pancreatic tissue
This would cause pancreatitis.

55
Q

how can alcohol, drugs, trauma, viruses or ischemia causes acute pancreatisis?

A

Leads to intracellular activation of proteases enzymes i.e. trypsinogen into trypsin

The activation of proteases lead auto-digestion of pancreatic tissue and pancreatitis.

56
Q

what is pernicious Anemia?

A

autoimmune condition that prevents the body from absorbing vitamin B12. this results in fewer red blood cells carrying oxygen throughout the body.

57
Q

how can pernicious anemia cause problems to the body?

A

can cause problems such as nausea, bloating and weight loss in digestive system.

muscle weakness, numbness or tingling in the hands and feet, memory loss and dementia.

heart problems that can cause palpitations (heart beating to fast or skipping beats).

weakness and faituge.

58
Q

what causes pernicious anemia?

A

an autoimmune condition that happens when your immune system produces antibodies that attack cells in the mucosal lining of your stomach and nerve cells. Your immune system’s response affects your body’s ability to absorb vitamin B12.

59
Q

how is pernicious anemia treated?

A

with IM vitamin b12 injection.
high doses of oral B12 replacement.
prescribe antibiotics if it is the bacteria in the intestine that prevents your body from absorbing vitamin B12.

60
Q

what are the signs and symptoms of pernicious anaemia?

A

fatigue,
lethargy (unusual decrease in consciousness),
dyspnea (SOB),
palpations,
syncope (passing out)
headache.

paraesthesia (tingling),
numbess,
cognitive changes,
visual disturbance.

61
Q

what is Hernia?

A

a bulge through an opening or weakness in the muscle or tissue that contains it.

most hernias involve one of your abdominal organs pushing through one of the walls of your abdominal cavity.

62
Q

what are the different types of hernias?

A

inguinal hernia- most common, affect males, happens when part of the bowel protudes into your inguinal canal. passageway that runs down your inner thigh.

femoral hernia- occurs in the femoral canal. which runs underneath the inguinal canal.

hiatal hernia- common. when the opening of the diaphragm where the esophagus passes throgh widens and the top of your stomach pushes up through the opening of the chest.

congenital diaphragmatic hernia: serious birth defect. the diaphragm doesnt close all the way during the fetal development. causing abdominal organs to slip up the chest cavity.

incisional hernia- when tissue protudes through a former incision.

umbilical hernia- when part of the intestine pokes through an opening in your abdominal wall near the belly button.

vetral hernia- through the front wall of the abdomen. above the belly button.

perinal hernia- organs or tissue push through an opening or weakness in your pelvic floor into the abdominal cavity.

63
Q

what can make you more likely to develop a hernia?

A

chronic cough,
chronic constipation,
history of abdominal or pelvic surgery,
pregnancy,
chronic obesity,
job that involves heavy lifting or many hours of standing.

64
Q

how would you treat a hernia?

A

surgery.

hernia repair- pushing the tissue back into place. using stitches to reinforce the barrier.

65
Q

what is a adhesion?

A

bands of scar tissue that form between the organs in the belly and pelvis. mainly forming loops of your small intestine. they can also form between an organ and the wall of your abdominal cavity.

66
Q

what are symptoms of abdominal adhesions?

A

severe abdominal pain,
cramping,
bloating,
nausea and vomiting,
abdominal distension (when your abdomen swells outward)
obstipation (being unable to pass gas or poo)

67
Q

what are the causes of abdominal adhesions?

A

they from after your body repairs injured tissue inside your abdominal cavity. internal scars.If an organ or tissue inside your abdominal cavity is damaged, your immune system triggers inflammation to heal the tissue. As part of the healing process, the damaged tissue forms scar tissue.
75% causes from surgery.
or can cauuse from conditions which make your abdominal inflammed

68
Q

what is intussusception?

A

a segment of your intestine (normally small intestine) folds partially inside the other. causing a bowel obstruction (blockage). can slow blood flow and prevent food from passing through it. can lead to swelling and inflammation that leads to life threatening complications.

69
Q

what are the symptoms of intussusception?

A

in children: episodes of severe, constant cramp abdominal pain, swollen belly, nausea & vomiting, red like stools

in adults:
adominal pain which comes and goes, vomiting, bloating and bloody stools.

70
Q

what is the treatment for intussusception?

A

in children using an contrast enema to stratighten out the childs intestine.

in adults- surgery

71
Q

what is volvulus?

A

occurs when part of the intestine loops around and folds over. this can cut of the tissues blood supply leading to symptoms such as extreme pain, bloody stool and bowel obstruction

72
Q

what is bowel cancer?

A

a growth of cells that begins in a part of the large intestine called the colon (the first and longest part of the large intestine) or rectrum.

73
Q

what are symptoms of bowel cancer?

A

bleeding from the rectrum or blood in your poo,
a change in normal bowel habit such as looser poo, constipation,
a lump which can be felt in your back passage or abdomen (right side more common),
strain in the rectrum (needing to poo)
loosing weight,
pain in the abdomen or back passage,
tiredness and breathlessness causes by a lower than normal level of red blood cells.

Sometimes cancer can block the bowel. This is called a bowel obstruction. The symptoms include:

cramping pains in the abdomen
feeling bloated
constipation and being unable to pass wind
being sick

74
Q

whats the diagnosis of bowel cancer? and treatment?

A

removing a sample of tissue for testing, blood tests, a scope to examine inside the colon.

removing polyps-polypectomy,
endoscopic mucosal resection- remove larger polyps.
laparoscopic surgery-removes polyps that cannot be removed during a coloscopy..

75
Q

what is appendicitis?

A

the appendix swelling, muscosal secreations increase intraluminal pressure. pressure exceeds capillary perfusion causing venous and lymphatic obstruction.

76
Q

how does the appendix get blocked in appendicitis?

A

lymphoid hyperplasia, (increase number of lymphoid cells)
infections,
fecaliths (mass of hard stone like dry feces)
tumours.

77
Q

what are signs and symptoms of appendicitis?

A

epigastric pain (pain or discomfort below the ribs and upper abdomen area),
cramping sensation,
right lower quadrant pain,
nausea, vomiting, diarrhea,
fever- high temp

78
Q

what is diabetes?

A

happens when your blood sugar (glucose ) is to high. when the pancreas doesnt make enough insulin or non at all. no insulin= glucose building up in the blood stream- high blood sugar- hyperglycemia.

79
Q

what are the different types of diabetes?

A

type 1-autoimmune disease in which your immune system attacks and destroys insulin producing cells.
type 2- body doesnt make enough insulin

80
Q

what are symptoms of diabetes?

A

increased thirst,
frequent urination,
fatigue,
blurred vision,
unexplained weight loss,
numbness or tingling in ur hands or feet,

81
Q

what causes diabetes?

A

to much glucose circulating in the blood stream.
insulin resistance due to lack of physical activity, diet, hormonal imbalences, genetics and certain medications.

autoimmune disease- type 1 when the immune system attacks the insulin-producing cells in the pancreas

hormonal imbalance- the placental releases hormones that can cause insulin resistance.

pancreatic damage- physical damage to the pancreas from a condition, surgery or injury, impact it making insulin.

genetic mutatations

82
Q

what are the complications of diabetes?

A

hyperglycemic state- type 2 mainly. when your blood sugar levels are really high for a long period. leading to severe dehydration and confusion.

DKA-mainly type 1 diabetes. if your body doesnt have enough insulin, it cannot use glucose for energy so it breaks down fat instead. which releases ketones which turns your blood acidic. causing vomiting and loss of consciousness.

severe hypoglycemia- affects people who use insulin.

83
Q

what does insulin do? and what cells are they?

A

reduces blood glucose levels

beta cells

84
Q

what does glucagon do? and what cells are they?

A

increases blood glucose levels

alpha cells

85
Q

what is DKA?
symptoms
treatment

A

when the blood becomes acidic because the body breaks down fat instead. which releases ketones which turns your blood acidic. causing vomiting and loss of consciousness.

this can lead to kussmaui respiration: depp labored breathing, reduced co2, reduce acidity.

treatment:
fluids, insulin (reduce blood glucose), electrolytes.

86
Q

what is acute liver failure?

A

when the liver looses function in days or weeks

87
Q

what causes acute liver failure?

A

extensive damage to liver cells where tissue can no longer function.
- paracetomol overdose
-herbal suppliments
-meds such as antibiotics-toxins
-hepatitis
-fatty liver
-shock
-cancer
-autoimmune disease
herpes, epstein

88
Q

what are symptoms of liver failure?

A

nausea and vommiting
jaudience
sleepiness
pain in the right upper abdo
tremors
confusion
abdo swelling