GI Neuromodulators

Question 1

AcH
A. Source= _____

B. Actions= _____ (3)

Answer 1

AcH
A. Source= Cholinergic Neurons

B. Actions:

1. Contracts Gut Wall Smooth muscle
2. Relaxes Sphincters
3. INC GPS (Gastric / Pancreatic / Salivary) SECRETIONS

Question 2

NorEpi
A. Source= _____

B. Actions= _____ (3)

Answer 2

NorEpi
A. Source= Adrenergic Neurons

B. Actions=

1. RELAXES Gut Wall Smooth muscle
2. CONTRACTS Sphincters
3. INC Salivary Secretions

Question 3

[Vasoactive Intestinal Peptide VIP]
A. Source= _____

B. Actions= _____ (2)

Answer 3

[Vasoactive Intestinal Peptide VIP]
A. Source= neurons of [mucosa AND Smooth m.]

B. Actions=

1. RELAXES Smooth m.
2. INC PIS (Pancreatic & Intestinal Secretions)

Question 4

[Bombesin GRP (Gastrin-Releasing Peptide)]
A. Source= _____

B. Actions= _____

Answer 4

[Bombesin GRP (Gastrin-Releasing Peptide)]
A. Source= Gastric mucosa neurons

B. Actions=
1. INC Gastric Secretions

Question 5

[Enkephalin Opiates]
A. Source= _____

B. Actions= _____ (2)

Answer 5

[Enkephalin Opiates]
A. Source= neurons of [mucosa AND Smooth m.]

B. Actions

1. DEC Intestinal Secretions
2. Contracts Smooth m.

Question 6

[Neuropeptide Y]
A. Source= _____

B. Actions= _____ (2)

Answer 6

[Neuropeptide Y] “Y u relax my smooth m. man??”
A. Source= neurons of [mucosa AND Smooth m.]

B. Actions=

1. DEC Intestinal Secretion
2. Relaxes Smooth m.

Question 7

[Substance P]
A. Source= _____

B. Actions= _____ (2)

Answer 7

[Substance P]
A. Source= CO-Secreted with AcH!

B. Actions=

1. Contracts Smooth m.
2. INC Salivary Secretion