GI Mod 3B Flashcards

1
Q

two forms of pyloric obstruction

A
  1. infantile hypertrophic pyloric stenosis

2. adult/acquired pyloric obstruction

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2
Q

what is IHPS

A

infantile hypertrophic pyloric stenosis: aka congenital pyloric stenosis

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3
Q

s/s of IHPS

A

infant at 2-3 weeks begins to vomit for no apparent reason

projectile vomiting - several feet

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4
Q

frequency of IHPS

A

infant disorder - 3/1000 births

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5
Q

pathophys of IHPS

A

pyloric sphincter is hypertrophied

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6
Q

etiology of IHPS

A

not fully established

hormones to allergic rxns have been suggested as potential cause

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7
Q

treatment of IHPS

A

surgery - pyloromyotomy

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8
Q

adult/acquired pyloric obstruction

  • cause
  • s/s
  • tx
A

caused by severe peptic ulcer or tumor in area
vague s/s of epigastric discomfort/fullness with eating that progresses to severe epigastric discomfort
gastric distention, nausea, progress to vomit and acute distress as obstruction develops over time
-tx: address cause of obstruction

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9
Q

types of mechanical obstructions

A
  1. adhesions
  2. herniation
  3. intussusception
  4. vulvulus (torsion)
  5. tumor growth
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10
Q

what are adhesions

A

fibrous scar tissue adheres to intestinal loops

common complication of abdominal surgeries

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11
Q

what are herniations

A

intestine protrudes thru abdominal wall

intestine may strangulate thru the opening…inguinal ring, umbilical hernia, hiatal hernia

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12
Q

what is intussusception

A

telescoping of one part of an intestine on another portion

more common in ileocecal area

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13
Q

what is volvulus (torsion)

A

intestine twists upon itself

the mesentary twists around strangulating the blood supply to the intestine

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14
Q

MC cause of LI obstruction d/t tumors

A

colon/rectal cancer is MC cause of LI obstruction

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15
Q

what causes functional obstruction in GI

A

paralytic ileus

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16
Q

what is paralytic ileus

A

obstruction that results when peristalsis stops

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17
Q

possible causes of ileus

A
certain drugs (narcotics or HTN drugs)
abdominal, spine or joint surgery
injury/trauma
infections/peritonitis
heart attack
imbalance of electrolytes
disorders that affect muscle function
low blood supply to parts of intestine (mesenteric ischemia)
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18
Q

treatment strategies of paralytic ileus

A

NG tube to decompress pressure within GI tract
address the underlying cause
if unsuccessful - surgery may be considered

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19
Q

Hirschsprung’s dz

A

aka congenital aganglionic megacolon

  • birth defect: ganglion nerve cells of the colon fail to develop
  • functional result: impaired motility of colon due to poor coordination/ability to contract intestinal musculature; impacted/trapped stool, infection, inflammation, and constipation
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20
Q

categories/types of Hirschprung’s dz

A

short - segment - rectosigmoid colon

long - segment - regions proximal to rectosigmoid are also involved

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21
Q

treatment strategies of Hirschsprung’s dz

A

decompress the colon (serial rectal irrigation) and surgical removal of involved intestinal segment

  1. mild-mod cases (short seg dz)
  2. severe cases (enterocolitis)
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22
Q

IBD - what is it

A

chronic autoimmune inflammatory dz that damages/ulcerates GI tract

23
Q

two forms of IBD

A
  1. Chrohns dz

2. ulcerative colitis

24
Q

what is Crohn’s dz

A

Crohn’s dz can affect any part of the GI tract, though it commonly occurs at the terminal end of the ileum of the SI and in the cecum of the LI

  • stress may exacerbate s/s but is considered a cause of the dz
  • s/s may be mild to severe
25
how many peeps in US have Crohn's
500,000 in US
26
peak onset of Crohn's
15-25 years up to 40
27
women or men are affected more with Crohn's
women
28
is Crohn's genetic
yes
29
what increases risk of Crohn's 2-4x
first degree relative with dz
30
etiology of Crohn's
cause is poorly understood - classic theories - gentics, autoimmune, environment
31
pathophys of Crohn's - what regions can it affect - types of lesions
inflammation extends thru all layers of intestinal wall chronic granulomatous inflammation may effect entire GI (mouth to anus) distal ileum and proximal colon most often involved isolated colonic involvement in 25% of cases skip lesions - two are more inflamed areas with healthy bowl in bw
32
what are granulomas in Crohn's
cluster of cells that form in area of inflammation
33
Pyloric obstruction
narrowing of pylorus
34
pharmaceutical tx of Crohn's Dz
antiinflammatory drugs - salicylate, corticosteroids, infliximab immune suppressors antibiotics
35
surgical tx of Crohns
intestinal resection | colostomy/ileostomy
36
what is ulcerative colitis
chronic inflammatory dz that affects the large intestine
37
pathophys of ulcerative colitis
etiology unknown inflammation extends to mucosa only (does not penetrate deeper layers) always involves rectum and extends proximally to contiguous secretions of colon
38
what are the different regional patterns in ulcerative colitis in LI
ulcerative proctitis proctosigmoiditis pancolitis
39
pharmaceutical interventions of ulcerative colitis
similar to crohn's
40
surgical tx of ulcerative colitis
1. total proctocolectomy (brooke ileostomy) entire colorectal mucosa excised 2. ileal pouch anal anastomosis pt maintains anal function an continence
41
what is diverticulosis
out pockets in intestinal wall 85% of pts are asymptomatic 15% develop colicky symptoms
42
pathophys of diverticulosis
colonic muscle wall weak where vessels penetrate | usually multiple diverticular present (smaller size)
43
distribution of diverticulosis
most commonly found in sigmoid colon
44
tx/management of diverticulosis
high fiber diet avoid high residue foods (seeds, nuts, corn) -anecdotal strategy based on theory to prevent from small undigested pieces from getting lodge in diverticula - evidence not fully established
45
what is diverticulitis
inflammation of the diverticuli | impacted with fecal material
46
what is most often affect in diverticulitis
sigmoid colon
47
colon perforations due to what in diverticulitis
inflammation
48
two types of perforations in diverticulitis
1. simple diverticulitis 2. complicated diverticulitis (perforations may or may not penetrate intestinal wall)
49
what % of newly diagnosed cancer in US is colorectal cancer
8.5%
50
pathophys of colorectal cancer
- most CRC develop from adenomatous polyp - initial mutant cancer cell develops in polyp - slow growth on polyp as it progresses down the stalk toward the deeper layers of the mucosa - if cancer penetrates into sub mucosal it can reach lymphatic/BV pathways and become highly malignant
51
how to prevent colorectal cancer
screening and removal of polyps
52
risk factors for CRC
age >50 PMH: IBD, adenomatous polyps >5mm, gall bladders urgery, pelvic irradiation FHx: 1st degree relative with colorectal cancer, familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer Lifestyle: tobacco and BMI >35-40
53
screening for CRC
colonoscopy - considered more thorough screening tool | sigmoidoscopy - limited in ability to screen
54
protocols for screening for CRC
average risk pts >50yo - colonoscopy every 10years - digital rectal exam and fecal occult blood yearly - pts with increased risk require more frequent or aggressive monitoring