GI Hormones Flashcards
Which 2 hormones are in the Gastrin family?
Gastrin
Cholecystokinin (CCK)
Which 2 hormones are in the Secretin family?
Secretin
Gastric inhibitory polypeptide (GIP)
Which peptide is under neurocrine control?
Gastrin releasing peptide (GRP)
Where is GRP released?
Post ganglionic fibres from vagus nerve all over the stomach
What do G cells secrete?
Gastrin
Where are G cells found?
Stomach antrum
What do I cells secrete?
Cholecystokinin (CCK)
Where are I cells found?
Duodenum
Jejunum
What is the effect of cholecystokinin (CCK)?
Increases pancreatic enzyme secretion
Stimulates gallbladder contraction
What is the effect of gastrin?
Stimulates parietal cells cells to secrete HCl
Stimulates gastric acid secretion
What stimulates G cells?
Vagus nerve stimulation via:
- Acetylcholine
- Gastrin releasing peptide (GRP)
Peptides in stomach lumen
What do D cells secrete?
Somatostatin
Where are D cells found?
Stomach pylorus
What is the effect of somatostatin?
Inhibit gastric acid secretion
What stimulates I cells to produce CCK?
Fats and protein
What do S cells secrete?
Secretin
Where are S cells found?
Duodenum
Jejunum
What is the effect of secretin?
Stimulates bicarb release from pancreas and gallbladder
Inhibits gastric acid secretion
Stimulates bile secretion from liver
What do K cells secrete?
Gastrin inhibitory peptide (GIP)
Where are K cells found?
Duodenum
Jejunum
What is the effect of gastrin inhibitory peptide?
Stimulates insulin release
Inhibits gastric acid secretion
What stimulates K cells to secrete GIP?
Sugars
Amino acids
Fatty acids
What do parietal cells secrete?
HCl
Intrinsic factor
Where are parietal cells found?
Stomach body
