GI Emergencies And Infection Flashcards

1
Q

What connects the greater sac and lesser sac of the peritoneal cavity?

A

Foramen of Winslow.

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2
Q

What is peritonitis?

A

Inflammation of the serosal membrane that lines the abdominal cavity.

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3
Q

What causes primary peritonitis?

How is it diagnosed?

A

Infection of ascitic fluid in the peritoneal cavity. Occurs commonly in patients with end stage liver disease.
Diagnosed by aspirating ascitic fluid and testing for a neutrophil count greater than 250 cells per mm^3

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4
Q

What causes secondary peritonitis?

A

Inflammatory process within the peritoneal cavity secondary to inflammation, perforation or gangrene of an intraabdominal structure. Common after surgery or appendicitis.

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5
Q

What non bacterial causes are there for secondary peritonitis?

A

Ovarian cyst,
Tubal pregnancy,
Blood in the peritoneum (this is highly irritant).

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6
Q

How does peritonitis present?

How is it treated?

A

Abdominal pain,
Nausea and vomiting,
Fever.
Patients are often immobile and take shallow breaths.
Treated with antibiotics or surgery to control the source.

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7
Q

What is the most common cause of bowel obstruction in children?

A

Intussusception - part of the gut tube telescopes into an adjacent section.

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8
Q

What are the classic signs of intussusception?

How is it treated?

A

Abdominal pain, vomiting and haematochezia.

Treated with an air enema or surgery.

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9
Q

What presenting symptoms may help indicate a small bowel obstruction?
What is the most common cause of this?

A

Nausea and bilious vomiting.

Intra-abdominal adhesions forming after surgery or damage to the mesothelium.

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10
Q

At what width is small bowel considered distended?

What about large bowel?

A

3cm.

6cm.

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11
Q

Which type of bowel obstruction is more common in the younger generation?

A

Small bowel obstruction.

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12
Q

What are common causes of large bowel obstruction?

A

Colon cancer,
Diverticular disease,
Volvulus of the sigmoid or caecum.

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13
Q

What is a volvulus?

What sign is typically seen on imaging?

A

Part of the colon that twists around its own mesentery, resulting in obstruction. Often occurs at the sigmoid colon as this has its own mesentery.
Coffee bean sign - distended bowel looks like a coffee bean.

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14
Q

What are plica circulares?

A

Full width bowel folds seen within the small bowel, often when it is distended.

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15
Q

What are the most common causes of acute mesenteric ischaemia?
Who is most at risk?

A

Arterial embolism of the superior mesenteric artery,
Low cardiac output,
Mesenteric venous thrombosis.
Most common in females and those with peripheral vascular disease.

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16
Q

How does acute mesenteric ischaemia commonly present?

How might it be diagnosed?

A

Excrutiating abdominal pain, disproportionate to clinical findings on examination, nausea and vomiting.
Blood tests for increased lactate levels, CT angiography and CXR to check for perforation.

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17
Q

How is acute mesenteric ischaemia treated?

What is the mortality rate?

A

Surgical resection of ischaemic bowel,
Thrombolysis,
Bypass grafts.
Mortality of approximately 70%.

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18
Q

How is a peptic ulcer defined?

Where are they most common?

A

Disruption of the gastric or duodenal mucosa that passes through the muscularis mucosa.
Common in duodenum, lesser curve and antrum.

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19
Q

What prehapatic, hepatic and post hepatic causes are there for oesophageal varices?

A

Prehepatic - portal vein thrombosis.
Hepatic - cirrhosis, schistosomiasis.
Post hepatic - hepatic vein thrombosis, right sided heart failure.

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20
Q

If oesophageal varices do not respond to ligation, what is the next step?

A

Transjugular intrahepatic portosystemic shunting (TIPS).
Bridges portal vein to hepatic vein, reducing variceal pressure.
Treatment with Terlipressin - lowers portal venous pressure.

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21
Q

How is abdominal aortic aneurysm defined?

A

Permanent pathological dilation of the abdominal aorta with diameter 1.5x expected of the segment, or approximately 3cm or more.

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22
Q

What are the four types of AAA?

Which is most common?

A
Suprarenal,
Pararenal,
Juxtarenal,
Infrarenal (most common).
Named in relation to renal arteries.
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23
Q

How might abdominal aortic aneurysm present?

A

Often asymptomatic until rupture.
Pulsatile abdominal mass,
Abdominal and back pain,
Transient hypotension caused by blood loss filing the peritoneum and compressing the aorta, stabilising blood pressure.

24
Q

How is abdominal aortic aneurysm managed?

A

If less than 5.5cm - monitor as may grow slow enough to not need treatment.
If more than 5.5cm - refer for vascular surgery - endovascular repair with ending raft inserted through femoral artery. Or open surgical repair.

25
Q

What are the benefits of the microbiome?

A

Harmful bacteria can’t compete for nutrients,
Microbiome produces anti microbial substances,
Produces certain nutrients eg vitamin K.
Important in beginnings of immune system.

26
Q

What are the three short chain fatty acids produced by bacteria in the colon and their functions?

A

Butyrate - energy source for colonocytes.
Acetate - involved in cholesterol metabolism.
Propionate - helps regulate satiety.

27
Q

What diets aid the function of the microbiome?

A

High fibre,
Probiotics (containing live bacteria)
Probiotics (such as accessible carbohydrates and fibre).

28
Q

What components damage the microbiome?

A

Sweeteners,
Gluten free diets,
PPIs,
Antibiotics.

29
Q

How might faecal microbiota transplant be administered?

A

Nasogastric tube,
Upper GI endoscopy,
Colonoscopy.
Transplant via caecum.

30
Q

What are the broad symptoms associated with bacterial infection of the GI system?

A

Nausea, vomiting, diarrhoea and abdominal pain.

31
Q

How does salmonella infect the gut?

A

Gain access to enterocytes,
Move to submucosa where they encounter Macrophages and are phagocytosed,
Transferred in macrophages to the reticuloendothelial system where they multiply inside cells and cause lymphoid hyperplasia,
Resented the gut via the liver.

32
Q

What shape are campylobacter species?

What food are they commonly found in?

A

Spiral or S shaped.

Chicken.

33
Q

Why might campylobacter infection cause bloody diarrhoea?

A

Campylobacter species release a cytotoxin that destroys cells of the intestine.

34
Q

which age group does shigella and shigellosis commonly affect?

A

Young children. Spreads via infected stool.

35
Q

What is the pathophysiology of shigella species?

A

Invade large intestine colonocytes, multiplying in cells and invading neighbouring cells. This kills colonocytes, causing abscesses and bloody diarrhoea with mucus.

36
Q

How does enterotoxigenic E-coli cause gastroenteritis?

A

Invades enterocytes and produces enterotoxins that result in hypersecretion of chloride ions into the gut, causing water to follow and diarrhoea.

37
Q

How long do each of the bacterial infections typically last?

A

Days - salmonella and Ecoli.
Approx a week - shigella.
Weeks - campylobacter.

38
Q

Which gram negative rods may cause haemolytic uraemic syndrome alongside gastro-enteritis?

A

Shigella, campylobacter (also the two that cause bloody diarrhoea).

39
Q

What type of bacteria is clostridium difficile?

A

Gram positive, anaerobic, spore forming bacillus.

40
Q

When does C-difficile infection most commonly occur?

What is the most common symptom?

A

Following antibiotic therapy.

Diarrhoea of varying severity (rarely bloody).

41
Q

How does C diff exert a cytotoxic effect?

A

Secretes toxins A and B. A - enterotoxin that increases permeability of enterocytes causing excessive secretion and inflammation.
Toxin B is directly cytotoxic.

42
Q

What complications can result from C diff infection?

A

Pseudomembranous colitis - inflammation and elevated yellow plaques that form a pseudo membrane.
Toxic mega colon and perforation with peritonitis.

43
Q

How is Clostridium difficile infection treated?

A

Remove offending antibiotics,
Fluid resuscitation,
Metronidazole or vancomycin,
Probiotics.

44
Q

Who does rotavirus commonly affect?

How does it cause diarrhoea?

A

Under 5s.
Chloride secretion, SGLT1 disruption and reduced brush border function.
Usually self limiting.

45
Q

What is notable about rotavirus?

Why does it cause vomiting?

A

Can affect any age due to large number of strains. Very resistant to cleansing.
Vomiting caused by delayed gastric emptying.

46
Q

How does cryptosporidium cause diarrhoea?

A

Oocyst is ingested and reproduces inside epithelial cells of distal small intestine, resulting in malabsorption and chloride secretion. Usually self limiting.

47
Q

Giardia commonly causes Giardiasis symptoms in which age group?
How long does infection last for?

A

Children.

Diarrhoea and abdominal cramping for up to 6 weeks after infection. Incubates for 10+ days

48
Q

How does giardia infect the GI tract?

A

Cyst is ingested and stomach acid releases parasite from cyst.
Parasite multiplies in the small intestine and damages proximal small intestine cells.
Parasite returns to cyst stage in the colon to perpetuate cycle.

49
Q

How is giardia treated?

What condition commonly occurs afterwards?

A

Antibiotics and fluid therapy.

Lactase deficiency and lactose intolerance.

50
Q

Where is entamoeba most common?

Who does it commonly affect?

A

Developing countries

People who have travelled to tropical places, live in poor sanitary conditions and men who have sex with men.

51
Q

How does entamoeba result in gastroenteritis?

A

Cyst is ingested and excystation occurs in colon where trophozoites (feeding stage) invade mucosa.
Cause bloody diarrhoea and inflammation similar to IBD.

52
Q

How is entamoeba treated?

What complications may arise?

A

Antiprotozoals/metronidazole.

May result in severe colitis or toxic mega colon.

53
Q

What is the most common cause of travellers diarrhoea?

How is it defined?

A

Enterotoxic E-coli.

Defined as 3 or more watery stools per day +/- fever and abdominal pain

54
Q

Who is most at risk of diarrhoea?

A

Under 6s, PPIs, Blood group O (shigellosis and cholera).

55
Q

How is gastroenteritis generally managed?

Why?

A

Fluid replacement therapy and monitoring.

Many infections are self limiting and antibiotic resistance is a growing problem. Many causes also viral.