GI Embryology Flashcards
Muscle cells fail to propagate region of pleuroperitoneal membranes (no scaffolding/ guidance for myoblasts) → weakened area → herniation of abdominal organs into thoracic cavity
Congenital Diaphragmatic Hernia
Bind tube cause via tracheoesophageal septum
Polyhydramnios
Esophageal Atresia
Abnormal connection between trachea + esophagus caused via tracheoesophageal septum
Polyhydramnios
Tracheoesophageal Fistula
Pylorus hypertrophies + thickens → narrowing of lumen → passage of food obstructed
Symptoms: projectile vomiting, polyhydramnios
Pyloric Stenosis
Partial occlusion of duodenal lumen due to incomplete recanalization
Duodenal Stenosis
Complete occlusion of duodenal lumen due to incomplete recanalization
Symptoms: Distention of epigastric region (infants), vomiting (contains bile) after birth, Polyhydramnios
Duodenal Atresia
Part of bile ducts are blocked/ or do not fully develop due to failure of recanalization
Extrahepatic Biliary Atresia
Duplication of gallbladder
Bifid gallbladder
Abnormal rotation so ventral bud forms ring of pancreatic tissue around the duodenum (rather than fusing completely)
- ring can compress duodenum → partial/ complete obstruction
Annular Pancreas
Persistence of physiological herniation of intestinal loops into the proximal part of umbilical cord
Congenital Omphalocele
Malformation of the anterior abdominal wall (incomplete closure of lateral folds - 4th week)
Results in abdominal viscera protruding into amniotic cavity
Gastroschisis
Intestines herniate again through imperfectly closed umbilicus
Umbilical Hernia
Proximal portion of yolk sac remains + forms diverticulum
Can become inflamed + mimic appendicitis
- wall of diverticulum may contain patches of gastric/ pancreatic tissue (secretes acid → ulceration + bleeding)
Merkel (ilea) Diverticulum
Both ends of vitelline duct transform into fibrous cords + middle portion forms large cyst
Vitelline cyst
External + internal Hemorrhoids
Superior 2/3 → internal → covered by mucous membranes + lack pain R
Inferior 1/3 → external → covered by skin + have pain R