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GI Drugs > GI drugs > Flashcards

GI drugs Flashcards

1
Q

Which drug has some antimicrobial properties, weak antacid, anti-secretory and antiinflammatory to the GI tract?

A

Bismuth subsalicylate

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2
Q

How does bismuth subsalicylate decrease gas production?

A

Binds hydrogen sulfide

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3
Q

MOA of cisapride? Prokinetic that works well where?

A

MOA - 5HT4/serotonin AGOnist –> stimulates release of ach into the enteric NS; parasympathomimetic. Good prokinetic for the LES and colon. `

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4
Q

MOA of cyproheptadine?

A

Serotonin antagonist

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5
Q

MOA of domperidone?

A

D2 antagonist

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6
Q

MOA of erythromycin in the GI tract?

A

Promotes motilin release; prokinetic

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7
Q

MOA of famotidine

A

H2 receptory antagonist

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8
Q

MOA of lactulose and magnesium salts??

A

Hyperosmotic laxatives; stimulate colon fluid and propulsive motility

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9
Q

MOA of maropitant? Found in the central and peripheral NS associated with _____, which is asso. with pain and stress? SE?

A

NK-1 receptor antagonist. Associated with substance P. Possible SE; hyptension in renal failure, may prolong the QT interval

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10
Q

MOA of metoclopramide? Uses?

A

D2 dopaminergic receptor antagonist in the CRTX and CNS; mixed 5-HGT3 antagonist and 5-HT4 agonist. Use: antiemetic and prokinetic

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11
Q

MOA misoprostol?

A

PGE analogue

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12
Q

MOA of octreotide? Effects of this drug?

A

Somatostatin analogue - somatostatin normally inhibits gastric, pancreatic and biliary secretions; prlongs GI transit time; decreased jejunal secretions

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13
Q

MOA of omeprazole? In an acidic environment, what happens to omeprazole? Other uses?

A

Inhibits the H/K ATPase; In the acidic environment, omeprazole is activated to a sulphenamide derivative that binds irreversibly at the secretory surface of the parietal cells –> inhibits transport of H ions into the stomach. Also inhibits cytochrome P-450. Decreases CSF production.

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14
Q

MOA of ondansetron?

A

5HT3/serotonin receptor ANTAgonist –> reduces the activity of the vaugs nerve which deactivates the vomiting center in the medulla oblangata.

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15
Q

MOA of phenothiazine (chlorpromazine)? SE?

A

Alpha 2 adrenergic antagonist. Hyptension

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16
Q

MOA of ranitidine? How does is stimulate motility?

A

H2 receptor antagonist. Stimulates motility by inhibiting acetylocholinesterases.

17
Q

MOA of somatostatin?

A

Blocks gastrin secretion

18
Q

MOA of simethicone?

A

Decreases gas bubble surface tension

19
Q

MOA of sucralfate?

A

Stimules PG synthesis from the gastric mucosa; offers mucosal protection by binding proteins

20
Q

MOA of sulfasalazine

A

Prostaglandin synnthestase inhibitor; antileukotriene

21
Q

What is Viokase?

A

Pancreatic enzyme concentrage of porcine origin (EPI).

GI Drugs (1 decks)

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