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NUR 326 Exam 3 > GI drugs > Flashcards

GI drugs Flashcards

1
Q

what drugs are H2 receptor antagonists

A

cimetidine and famotidine

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2
Q

MOA of cimetidine and famotidine

A

Blocks H2 receptors in the stomach, reduces gastric acid secretion, increases stomach pH

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3
Q

indications for cimetidine and famotidine

A

GERD, PUD, ulcer prophylaxis, heartburn/dyspepsia

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4
Q

considerations for cimetidine

A

inhibits CYP450 - careful with warfarin, phenytoin, theophylline

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5
Q

nursing consideration for famotidine

A

give iV slowly to avoid bradycardia

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6
Q

what drugs are proton pump inhibitors

A

Omeprazole
Pantoprazole
Esomeprazole magnesium

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7
Q

MOA of PPI

A

Binds to proton pump
Inhibits the hydrogen potassium ATPase enzyme system

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8
Q

indications for PPIs

A

short term treatment of PUD and GERD

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9
Q

PPI adverse reactions

A

short term: relatively safe
longer term: increased risk for pneumonia, bone loss/hip fx, stomach CA

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10
Q

what drug is a mucosal protectant

A

sucralfate

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11
Q

MOA of sucralfate

A

Alters when exposed to gastric acid
-sticky, thick gel –> protective barrier

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12
Q

indication for sucralfate

A

duodenal ulcers, gastric ulcers

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13
Q

adverse effects of sucralfate

A

well tolerated
constipation

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14
Q

considerations for sucralfate

A

decreased drug absorption–> don’t take before other drugs
PO

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15
Q

what are antacids used for

A

PUD, GERD, stress ulcers

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16
Q

nursing considerations for antacids

A

chelation when taken with other drugs
-chelation: alter gastric absorption b/c chelate/connect
separate from other drugs by 1-2hr

17
Q

what drug is serotonin blocker

A

ondansetron (zofran)

18
Q

MOA for ondansetron

A

Blocks serotonin receptors in the trigger zone in the b rain and in the afferent vagal nerves in the stomach and small intestine

19
Q

indications for ondansetron

A

n/v

20
Q

ondansetron adverse effects

A

Mild: headache, diarrhea, dizziness
Serious: serotonin syndrome

21
Q

nursing considerations for ondansetron

A

Careful with SSRIs, SNRIs, TCAs, MAIs, buspirone, tramadol

22
Q

what drugs are antihistamines

A

dimenhydrinate (Dramamine)
meclizine
hydroxyzine

23
Q

MOA of antihistamines

A

Blocks the release of histamine H1 receptors in the inner ear

24
Q

indications for antihistamines

A

Dizziness and nausea
Antiemetic and antivertigo – motion sickness

25
Q

adverse effects of antihistamiens

A

sedation, drowsiness AND anticholinergic effects

26
Q

nursing considerations for antihistamines

A

fall risk

NUR 326 Exam 3 (1 decks)

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