gi drugs Flashcards
Omeprazole, Iansoprazole
PPI
MoA of PPI
Irreversible inhibition of gastric gland parietal cell H/K - ATPase, present in apical membrane. Block the final common pathway which all secretiveness invrease gastric production by so is the most effect way of reducing the latter
What are PPIs
Prodrugs that are activated in the acidic environment of the canaliculus contributing to their effectiveness and selectivity of action
Indication of PPI
Prevention of peptic ulcer disease, symptom relief of GORD, eradication of Hpylori
Adverse effects of PPI
Headache, diarrhoea, abdominal pain, nausea fatigue, increase risk of c. Diff prolonged PPI therapy may result in rebound acid hypersecretion upon discontinuation
Warnings of PPIs
May disguise gastric cancer, long term therapy in elderly may increase risk of bone fracture. Interactions with cytochrome P450 isoenzymes may decrease the anti platelet activity of phenytoin and warfarin
Ranitidine
H2 receptor antagonist
MoA of H2 receptor antagonist
Competitive antagonist of H2 receptors on gastric parietal cells, reduces gastric acid secretiom
Uses of H2RA
Prevention and treatment of peptic ulcer disease, symptomatic relief fog dysteptpsi of GORD
SE of H2RA
Diarrhoea, headache, abdominal pain and dizziness, gynaecomastia, important an potentials warfarin
Warnings of H2RA
Disguise gastric cancer
Loperamide, codpiene phosphate
Antimotility drugs
MoA of loperamide
Oral opiode agonist with activity on u opioid receptors expressed by enteric neurones of the GI tract
What is codiene susceptible to
Misuse and may induce tolerance and dependence
Adverse effect of antinotility drugs
Constipation, abdominal cramping and flactulence
