GI Disorders Flashcards
Function of the GI tract (4)
Digestion
o physical breakdown and chemical alterations of food stuff to allow absorption along GI tract
o Involves GI motility, pH changes, biological detergents and enzymes
Absorption
o Direct movement of nutrients across the intestinal lining
Excretion
o Food residue, hydrophobic molecules (drugs bacteria and dead cells)
Host defense
o Largest lymphoid organ in the body with extensive surface area
o Gut microbiome
o
Function of the esophagus
-Fibromuscular tube connecting the throat with the stomach
-Food passes by peristaltic contractions
Sphincters: bundles of muscle that control entry/exit
o Upper esophageal sphincter
o Lower esophageal sphincter
Explain GERD and contributing factors
Reflux of gastric contents into the esophagus causes heartburn
contributing factors:
1. incompetent lower esophageal sphincter
2. impaired gastric emptying
3. Hiatal hernia
4. Alcohol abuse
more common in children with developmental delays
Complications of GERD
- Regurgitation/malnutrition
- Esophagitis- inflammation of the esophagus
- Barretts Esophagus
-Transformation of the normal esophagus squamous epithelium to columnar epithelium “pre malignant”
-Increased risk of developing esophageal cancer - Respiratory compromise: Associated with asthma and COPD
Function of the Stomach
- Reservoir function: controlled release of chyme into small intestine
- mechanical digestion: gastric motility peristalsis
- chemical digestion: digestive enzymes continue digestion of protein and fats
- Hydrochloric acid: chemical digestion activates digestive enzymes; immune defense
- Intrinsic Factor (IF): binds vitamin b12 for absorption
If there is an issue with intrinsic factor in the stomach what happens? Where is intrinsic factor produced
individual will become vitamin b12 deficient
intrinsic factor is produced in the parietal cells
Cell types within the stomach allow for what?
alot of cell types in the stomach secrete mucus to protect the stomach from its own acidity
Define Gastritis and acute causes
Gastritis: inflammation of the inner lining of the stomach
excessive acid production> gastric defense
ex: NSAID, ASA, ETOH
Stress induced
ex: common in critical illness
Define Peptic Ulcer Disease
increased acid secretion and digestive enzymes that erode the gastric mucosa
Helicobacter pylori infection: infection leading to PUD
Complications of PUD
Hemorrhage, peroration, peritonitis, scarring
defined by site of origin
15% of long term ___ users develop peptic ulcer disease
NSAID
Asprin, ibuprofen and cox2 inhibitors
What are the risk with NSAID/Asprin
pain relief with GI bleeding risk blocks both COX1 and COX2
What are the risks with COX2 inhibitors
pain relief with decreased GI bleed risk but Increased MI/CVA risk
GI Bleed Red Flags
- Syncope (passing out)
- hypotension
- pallor
- diaphoresis
- Tachycardia
Coffee ground emesis/ black tarry stools indicate what type of GI bleed
UGIB
not good
Blood in stool indicates what type of GI bleed
LGIB
What examination items would you include for a pt who has a PMH including GIB
review the H & H values- look for trends slow decrease in value recognize that the blood volume is less and less oxygen carrying capacity
normal RBC around 13-17 male
female 12-15
Function of the small intestine
- mixes and grinds (segmentation) and propels (peristalsis) contents
- digests and absorbs nutrients
- secretes regulatory hormones
mainly absorbs nutrients!!!!
Explain Small Intestine segmentation
mixes and grinds breaks down food
Explain small intestine peristalsis
propels food bowel forward
Function of Large Intestine
main function of large intestine is reabsorption of water along with ions and some vitamins
What is the same and different about crohns disease and ulcerative colitis
Crohns Disease: inflammation that involves the entire bowel wall
pain in the lower right abdomen
Ulcerative Colitis: involves inflammation of the inner most lining of the bowel wall
pain is common in the lower left abdomen
Both involve joint pain and the medication taken suppresses the immune system thus these individuals are at a higher risk of infection
Common presentation of Crohns and Ulcerative Colitis
abdominal cramping, pain, diarrhea, obstruction, fatigue, malabsorption, leading to weight loss and malnutrition
What is IBS
o Disturbed bowel function without structural abnormalities
o Spasmodic motility pattern
o Malabsorption
o Nutrient deficiency and loose stools
o Etiology is unknown but IBS is believed to be related to colonic sensitivity
o Diagnosis of exclusion