gi disorders Flashcards

1
Q

Upper and lower GI :

A

Upper : Esophagus, Stomach, Beginning of small intestines

Lower GI: Small intestines, colon (large intestines), rectum/anus

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2
Q

upper GI problems

A

esophageal:
- GERD
- Hiatial Hernia

Inflammatory disorders of stomach:

  • gastritis
  • acute gastroenteritis
  • PUD
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3
Q

dysphagia definition

A

Defined: Difficulty swallowing
Begins with solids and progresses to liquids

Common Causes:

  1. Mechanical obstruction
    - Stenosis or stricture
    - Diverticula
    - Tumors
  2. Neuromuscular dysfunction, intubation or trach
    - CVA
    - Achalasia
    – LES (lower esophageal sphincter) can’t open properly
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4
Q

what is GERD?

A
  • gastroesophageal reflux disease
  • upper GI problem
  • esophageal disorder
  • Backflow of gastric acid from the stomach into the esophagus
  • Occurs via the lower esophageal sphincter (LES)
  • Highly ACIDIC material!
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5
Q

gerd etiology

A
Anything that alters closure strength of LES or increases abdominal pressure
Examples:
Fatty foods
Spicy foods
Tomato based foods
Citrus foods
Caffeine
Large amounts of alcohol
Cigarette smoking
Sleep position
Obesity
Pregnancy
Pharmacologic agents
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6
Q

gerd clinical manifestations

A
Heartburn (pyrosis)
Dyspepsia - indigestion
Regurgitation
Chest pain
Dysphagia
Pulmonary symptoms
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7
Q

gerd complications

A

Complications:
ulceration
scarring
strictures
Barrett esophagus (development of abnormal metaplastic tissue - premalignant)
**Three-fold increased risk of developing adenocarcinoma of the esophagus
Overall survival only 17%

**longterm GERD = increased risk esophageal

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8
Q

hiatal hernia

A

A defect in the diaphragm that allows part of the STOMACH to pass into the THORAX

Two Main Types:
1. Sliding hernia – usually small and often do not need treatment** less severe
2. Paraesophageal hernia- part of the stomach pushes through the diaphragm and stays there- peritonial becomes thin
**more severe
3-4. mix of type 1 & 2 and increase with severity

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9
Q

hiatal hernia: pathophysiology

A

Exact cause is unknown
Age related Injury or other damage may weaken the diaphragm muscle
Repeatedly putting too much pressure on the muscles around the stomach
- Severe coughing
- Vomiting
- Constipation and straining to have a bowel movement

**obesity increases risk

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10
Q

risk factors hiatal hernia

A

age
obesity
smoking

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11
Q

clinical manifestations hiatal hernia

A

Asymptomatic
Belching
Dysphagia
Chest or epigastric pain

**common for hiatal hernia and GERD to coexist

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12
Q

hiatal hernia tx

A

Mostly a conservative treatment
Teaching: small, frequent meals, avoid lying down after eating
Avoid tight clothing and abdominal supports
Weight control for obese individuals
Antacids for the GERD/esophagitis symptoms
Surgery if the conservative treatments do not work

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13
Q

what is gastritis

A

inflammatory condition of the stomach

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14
Q

acute gastritis

A

Defined: TEMPORARY inflammation of the STOMACH lining only (intestines NOT affected)
Generally last from 2-10 days

Etiology:
Irritating substances (**alcohol
Drugs (NSAIDs) - stop prostaglandin secretion in stomach
Infectious agents - h. pylori

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15
Q

chronic gastritis

A

PROGRESSIVE disorder with chronic inflammation in the stomach
Can last weeks to years

Complications: PUD, bleeding ulcers, anemia, gastric cancers
Two main etiologies:
Autoimmune - Attacks parietal cells
H. pylori infection - acute or chronic

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16
Q

what is h. pylori

A

Helicobacter pylori bacterium- gram negative spiral bacteria
Acidic environment
Destructive pattern of persistent inflammation
- Can cause chronic gastritis, PUD, and stomach cancer

How is it transmitted?

  • Person to person via saliva, fecal matter, or vomit
  • Contaminated food or water
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17
Q

clinical manifestations acute/chronic gastritis?

A
Sometimes none
Anorexia
N/V
Postprandial (after eating) discomfort
Intestinal gas
Hematemesis
Tarry Stools
Anemia
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18
Q

what is acute gastroenteritis

A

Inflammation of stomach & SMALL INTESTINE

Etiology:
Viral infections: Norovirus and rotavirus
Bacterial infections: E. col, salmonella, campylobacter
Parasitic infections

Usually lasts 1-3 days but may last as long as 10 days

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19
Q

clinical manifestations and complications acute gastroenteritis

A

Clinical manifestations
*Watery Diarrhea
May be bloody if bacterial

Abdominal pain
N/V
Fever, malaiseComplication: fluid volume deficits
** decreased fluid = increased dehydration

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20
Q

what is peptic ulcer disorder (PUD)?

A

Ulcerative disorder of the upper GI tract

  1. Esophageal
  2. Stomach - gastric ulcers
  3. Duodenum - peptic ulcer in the first part of the small intestine

Develops when the GI tract is exposed to acid and h. pylori

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21
Q

what are factors that influence healthy GI balancing?

A

aggressive factors (causing ulcers)

  • h. pylori
  • NSAIDs
  • acid
  • pepsin
  • smoking

defensive factors

  • mucus
  • bicarbonate
  • increased blood flow
  • prostaglandins
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22
Q

peptic ulcer disease etiology

A

H. pylori
Injury-causing substances
**NSAIDs, ASA, alcohol
Excess secretion of acid
SmokingFamily history
Stress - remember there is increased gastric acid secreted with the stress response
**can worsen the response not the actual cause tho

23
Q

risk factors NSAIDs PUD

A

**inhibits prostaglandin synthesis and decreases mucus protection in stomach
Age
Higher doses of NSAIDs
History of PUD
Use of corticosteroids and anticoagulants
Serious systemic disorders
H. pylori infection

24
Q

PUD pathogenesis

A

Mucosa is damaged
Histamine is secreted, resulting in:
Increase in acid and pepsin secretion
– causes further tissue damage

Vasodilation
– causes edema
***If blood vessels are destroyed, this results in BLEEDING

25
PUD classification - Duodenal ulcer
``` ***Most common type Age – any; early adulthood Gastric/peptic ulcer Age – peak 50 - 70 Why? Increased use of NSAIDS, corticosteroids, anticoagulants and more likely to have serious systemic illnesses ```
26
PUD clinical manifestations
``` Sometimes none N/V, anorexia Weight loss Bleeding Burning Pain - in middle of abdomen that is usually worse when the stomach is empty ```
27
describe gastric ulcers
burning, cramping, gas-like epigastric, back 1-2 hours after eating
28
describe duodenal ulcers
burning, cramping, gas-like epigastrium, back ***2-4 hours after eating
29
how to best decipher btw gastric and duodenal PUD?
timing!! gastric - 1-2 hrs after eating duodenal - 2-4 hrs after eating
30
PUD complications (HOP)
``` “HOP” Complications H – Hemorrhage O – Obstruction - scarring tissue bondage P – Perforation and Peritonitis ```
31
what are the lower GI disorders
appendicitis peritonitis irritable bowel disorder inflammatory bowel disorder - Crohn's and ulcerative colitis diverticulosis/diverticulitis
32
appendicitis
Inflammation of the appendix **RLQ pain Etiology Appendix is OBSTRUCTED Leads to INFLAMMATION Complications Gangrene Abscess formation ****PERITONITIS
33
appendicitis and pain
Classic Pain: RLQ in periumbilical area Rebound Pain Sudden pain relief may indicate rupture - Peritonitis Rebound Pain = Pain is SEVERE after release of palpating hand over the RLQ
34
what is peritonitis
Inflammation of the PERITONEUM (abdominal cavity) Serous membrane that lines abdominal cavity & covers visceral organs (like the pleura for lungs)What happens to the peritoneum? - INFLAMMATION - Fluid shifts – THIRD SPACING - Can lead to hypovolemic shock and sepsis DECREASED PERISTALSIS - Can lead to paralytic ileus and intestinal obstruction
35
causes peritonitis
``` perforated ulcer ruptured gallbladder pancreatitis ruptured spleen ruptured bladder ruptured appendix non-asepsis during peritoneal dialysis ```
36
clinical manifestations peritonitis
``` Usually sudden and severe Abdominal pain* severe ***Tenderness Rigid “board-like” abdomen **hard to touch** N/V ``` ``` Others: Fever Elevated WBC HR _____increased____ BP ____decreased_____ ```
37
lower GI problems
irritable bowel syndrome (IBS) | inflammatory bowel disease (IBD)
38
IBS - irritable bowel syndrome
Chronic condition characterized by: alterations in bowel pattern due to changes in intestinal motility, Chronic and frequent constipation (IBSC) Chronic and frequent diarrhea (IBSD)
39
symptoms IBS
Symptoms: vary by individual Abdominal distension, fullness, flatus, and bloating Intermittent abdominal pain exacerbated by stress and ***RELIEVED BY DEFECATION Bowel urgency Intolerance to certain foods (sorbitol, lactose, gluten) Non-bloody stool that may contain mucous
40
stress and IBS
IBS is almost never the result of primarily psychological causes “Emotional stress did not cause my illness” IBS can be exacerbated by stress “Emotional stress can make my illness worse.” IBS can cause stress and psychological problems “My IBS is stressful to live with and may cause me to have emotional problems.” Cause UNKNOWN but thought to be “triggered” by stress, food, hormone changes, GI infections, menses
41
inflammatory bowel disease - 2 types?
A group of life-changing, chronic illnesses TWO SEPARATE DISORDERS: Crohn’s disease Ulcerative colitis Characterized by: Chronic inflammation of the intestines Exacerbation and remissions More common in WOMEN, Caucasians, persons of Jewish descent, and smokers Etiology? Genetically AUTOIMMUNE activated by an infection
42
crohn's disease - pathogenesis
Lymph structures of the GI tract are blocked Tissue becomes engorged and inflamed Deep linear FISSURES and ULCERS develop in a ”patchy” pattern in the bowel wall ---SKIP LESIONS---COBBLESTONE APPEARANCE ``` Complications: Malnutrition Anemia Scar tissue and obstructions Fistulas- connections btw 2 structure that's not normal Cancer ```
43
crohn's disease clinical manifestations
Crampy lower Abdominal pain (RLQ) Watery diarrhea SYSTEMIC: Weight loss, fatigue, no appetite, fever, malabsorption of nutrients Palpable abdominal mass (RLQ) Mouth ulcers S/S of fistulas - location dependent ***granulomas and skip lesions****
44
ulcerative colitis definition
Inflammation of the mucosa of the RECTUM AND COLON Usually develops in the third decade of life More common in white people of European descent, esp. Ashkenazi Jewish descent Occasionally in Black/African Americans Rare in Asians
45
ulcerative colitis pathogenesis**crypt abscesses
Inflammation begins in the rectum and extends in a CONTINUOUS segment that may involve the ENTIRE colon Inflammation leads to large ulcerations Necrosis of the epithelial tissue can result abscesses – CRYPT ABSCESSES Colon and rectum try to repair the damage with new granulation tissue Why is this a problem? Tissue is fragile and bleeds easily
46
ulcerative colitis clinical manifestations
Abdominal pain ***Bloody diarrhea - not typical with crohns Systemic: Weight loss, fatigue, no appetite, fever
47
complications ulcerative colitis
``` Hemorrhage - bc of new granulation tissue Perforation Cancer Malnutrition Anemia Strictures FISSURES ABSCESSES - rectal, colon, anal TOXIC MEGACOLON – a rapid dilation of the large intestine that can be life-threatening ``` COLORECTAL CARCINOMA Liver Disease – from inflammation and scarring of bile ducts Fluid, electrolyte and PH imbalances -increase risk vte/dvt
48
diverticular disease pathogenesis
Development of diverticula: Small pouches in lining of colon that bulge outward through weak spots May be CONGENITAL or ACQUIRED Thought to be caused by low fiber diet with resulting chronic constipation Usual location: DESCENDING COLON
49
diverticulosis vs diverticulitis
diverticulosis - not inflamed | diverticulitis - inflammed
50
diverticulosis clinical manifestations
Usually asymptomatic | Discovered accidently or with presentation of acute diverticulitis
51
diverticulitis
``` INFLAMMATION of one or more of the pouches (diverticula) Usually from retained fecal material Clinical manifestations Abdominal pain – LLQ Fever WBC’s __increased_ Constipation or diarrhea Acute – passage large quantity of frank blood May resolve spontaneously ``` Complications Perforation Peritonitis Obstruction
52
pyrosis?
heartburn
53
dyspepsia?
indigestion