GI Diseases (Exam III) Flashcards
What are general symptoms of esophageal diseases?
- Dysphagia
- Heartburn
- Regurgitation
- Chest pain
- Odynophagia
- Globus sensation
Differentiate dysphagia and odynophagia.
- Dysphagia - difficulty swallowing
- Odynophagia - painful swallowing
What is a normal LES (lower esophageal sphincter) resting tone?
29 mmHg
What is Achalasia?
What does it result in?
- Esophageal obstruction due to inadequate LES relaxation (usually from LES HTN).
- Reduced peristalsis and dilated espophagus
What is the biggest risk with achalasia?
How would anesthetic practices change for a achalasia patient?
- Aspiration
- NPO for 24-48 hours prior to Heller myotomy or POEM.
How is achalasia treated?
Through relief of obstruction (can’t fix peristalsis).
- Nitrates (low dose)
- CCBs (low dose)
- Botox
- Balloon Dilation
- Heller Myotomy (LES reduction)
- Per Oral endoscopic myotomy
How would a esophageal motility vs structural issue be delineated?
- Structural = difficulty w/ solids
- Motility = difficulty w/ solids & liquids.
How would a esophageal motility vs structural issue be delineated?
- Structural = difficulty w/ solids
- Motility = difficulty w/ solids & liquids.
What would an esophageal spasm look like under direct visualization?
- Corkscrew or rosary bead appearance.
What medications could be used to treat esophageal spasms?
- Nitroglycerin
- Trazodone
- Imipramine
- Sildenafil
What is an esophageal diverticulum?
What kinds are there?
Esophageal wall out-pouching
- Pharyngoesophageal (Zenker’s)
- Mid-esophageal
- Epiphrenic (supradiaphragmic)
What are the main symptoms of esophageal diverticula?
- Halitosis (bad breath)
- Dysphagia (worse with larger pockets)
What is the treatment for esophageal diverticula?
- Small - medium: nothing
- Medium - large: removal
What are anesthesia considerations and risks for esophageal diverticula?
- No cricoid pressure
- Avoid NGT
- Intubate w/ head elevated
- Aspiration risk
What type of hernia is depicted by 1 on the figure below?
Normal (no hernia)
What type of hernia is depicted by 2 on the figure below?
Sliding Hiatal hernia
What type of hernia is depicted by 3 on the figure below?
Paraesophageal Hiatal hernia
What types of cancer are normally seen with esophageal cancer?
Where are they located typically?
- Squamous cell carcinoma (mid-esophagus)
- Adenocarcinomas (distal esophagus)
What signs/symptoms are indicative of esophageal cancer?
- Progressive dysphagia
- Weight loss
- Pancytopenia
- Lung Injury
- Malnourishment/dehydration
What is the treatment for esophageal cancer?
- Esophagectomy
- Chemotherapy
- Radiation
What deficient LES pressure is typically seen with GERD?
13 mmHg
What typically causes GERD?
- LES hypotension
- GE junction abnormality (hiatal hernia)
What complications can occur with chronic GERD?
- Esophagitis
- Laryngopharyngeal reflux
- Recurrent pulmonary aspiration (chronic cough)
What treatments are used for GERD?
- Lifestyle modifications
- PPIs > H2 antagonists
- Niessen fundiplocation
What are anesthesia considerations for GERD patients?
Manage Aspiration risk
- Ranitidine > cimetidine
- PPI’s
- Na⁺ citrate + reglan
- RSI + Cricoid pressure recommended.
What is peptic ulcer disease (PUD) ?
How does it present and what causes it?
- Ulcers of mucosal lining of stomach or duodenum causing a burning epigastric pain; caused by H. Pylori decreasing normal gastric mucosa HCO₃⁻ .
- H. Pylori + NSAIDs.
Who is at greater risk for PUD?
- Alcoholics
- Elderly
- Malnourished
What significant risk factors come from untreated PUD?
- Bleeding
- Peritonitis → sepsis
- Dehydration
- Perforation
What is the mortality risk of bleeding from PUD?
- 10 - 20%