GI Flashcards
Acid Reducing Drugs
Antacids - Mg and Al hydroxide - CaCO3 - NaHCO3 H2 Antagonists - Ranitidine - Cimetidine - Famotidine - Nizatidine Proton Pump Inhibitors - Omeprazole - Esomeprazole - Lansoprazole - Dexlansoprazole
Antacids
Mechanism: - chemically neutralize acid that is present Short lived Use: - occasional GERD or dyspesia - discriminate chest pain MI vs acid reflux Drugs: MgOH - diarrhea - hyperMg in renal pts AlOH - constipation - hypophosphatemia - decrease drug adsorption CaCO3 - produce CO2 - belching/bloating - constipation - hyperCa - kidney stones - acid rebound NaHCO3 - produce CO2 - belching/bloating - systemic alkalosis in renal pts - fluid retention - Na
H2 antagonists
Mechanism:
- prevent histamine induced activation of H release - block histamine binding H2 receptors on parietal cells, no cAMP production
- decrease proton and pepsin secretion in dose dependent manner
Use:
- heartburn and dyspesia, GERD
- added to PPI for nocturnal breakthrough
- stress ulcer prophylaxis
- peptic ulcer healing and zollinger-ellison syndrome, but prefer PPIs
Tachyphylaxis
Drugs:
Cimetidine
- large doses: inhibits cyp450
- antiandrogenic - gynecomastia and galactorrhea
- cardiovascular problems
- confusion in elderly
Ranitidine
Famotidine
Nizatidine
Proton Pump Inhibitors
Mechanism:
- directly block parietal H-K ATPase to decrease H secretion into lumen, irreversible block
- needs conversion to sulfenamide via acid
Most effective when parietal cells create the most acid - take before meal, preferably before 1st meal of day
Don’t take with H2 blockers cuz need the acid
Use:
- peptic ulcer disease, GERD, reflux esophagitis
- H pylori with abx
- Zollinger Ellison syndrome
- IV form used for upper GI bleed to reduce need for intervention and reduce risk of rebleeding after intervention
Drugs:
Omeprazole
Lansoprazole
Dexlansoprazole
Pantoprazole
Esomeprazole
Adverse events:
- common: headache, abdominal pain, nausea, diarrhea, flatulence
- p450 metabolism so drug interactions (clopidogrel be aware)
- increased risk of GI infxns - check for C diff if pt has diarrhea
- increase risk of fracture
- increased risk of pneumonia
- risk of hypomagnesemia - check Mg levels
Mucosal Protectants
Bismuth Salts
Sucralfate
Misoprostol
Bismuth Salts
Action: - coats ulcers and inflamed areas Use: - gastroenteritis - symptoms of nausea, dyspepsia, diarrhea - traveler's diarrhea prophylaxis Side effects: - black tongue and feces - interactions with anticoagulants
Sucralfate
Action:
- forms temporary coating on ulcers, protects them from acid and digestive enzymes
Take before meals
Use:
- stress ulcer prophylaxis (not much anymore)
- bile reflux gastritis and esophageal ulcers post variceal banding
Misoprostol
Prostaglandin E1 analog Action: - stimulates mucous production - decreases acid secretion Uses: - induces labor - use in pts with chronic NSAID use cuz of ulcer risk with reduced PGE1
GI motility agents
Erythromycin - Abx Cholinomimetics - bethanechol, neostigmine Dopamine receptor antagonists - metoclopramide, domperidone Serotonin - metoclopramide
Erythromycin
Macrolide abx Action: - activates motilin receptors on smooth muscle of antrum and small intestine Use: - diabetic gastroperesis Adverese events: - tachyphylaxis - QT prolongation
Cholinomimetics
Neostigmine, Bethanechol - increase GI motility big time Use: - Ogilive syndrome (IV) Side effects: - cholinergic
Metoclopramide, Domperidone
Dopamine receptor antagonists - pre and post synaptic
Action:
- promote gastric/intestinal motility through Ach release
- increase gastric tone
- improve antroduodenal coordination
- accelerate gastric emptying
Side effects of metoclopramide:
- reversible: somnolence, feeling jittery, headache, diarrhea
- serious side effects: tardive dyskinesia, dystonia, neuroleptic malignant syndrome
Laxatives
Bulk forming - Fiber - psyllium Osmotic Agents - Magnesium salts - polyethylene glycol - Lactulose - PED - milk of magnesia Stimulants - Bisocodyl - Senna - Castor oil - Cascara Stool Softeners - Docusate - Mineral Oil Cl channel secretion - Lubiprostone GC-C agonist - Linaclotide
Psyllium, Polycarbophil
Fiber laxative - Bulk laxatives Action: - form gels in the colon causing water retention and distention - increase peristalsis
Polyethylene glycol, Mg salts, milk of magnesia
Osmotic laxative
Action:
- draw H2O into intestinal lumen via osmosis resulting in softer/liquid stools and distension induced peristalsis
Bisacodyl/Dulcolax, Senna
Stimulant laxative
Action:
- stimulates colonic smooth muscle and causes H2O accumulation in lumen
Docusate
Surfactant
Stool softener - laxative
Action:
- causes fat/H2O to mix