GI Flashcards
Aspects of a healthy gut
Proper nutritional substrates, micro nutrients, and phytonutrients for maintenance of commensal flora, immune modulatation, and repair and regeneration
Proper mastication
Adequate digestive juices, enzymes, and pH
Intact intestinal epithelial barrier function
Balanced host bacteria ecology
Autonomic balance
Overview of the gut
The gut lumen is not inside the body
Gut is a dynamic physiologic Organ
The primary functions of The gut are
Digestion and absorption of nutrients
Houses and supports the function of over 70% of the entire immune system
Barrier to differentiate friend from foe
Organizes initiates and coordinate the metabolism of nutrients in the process of detoxification
What can cause a sick gut
Poor diet Dehydration Interaction of medications Toxins metals molds foods Inadequate digestive enzymes, pancreatic, bio, Hypochlorhydria altered pH Imbalanced ecology Impaired intestinal permeability Alter Neuro endocrine balance and autonomic function
Why The gut
70% of Americans have gut symptoms
The most sensitive organ with multiple common insults that lead to dysfunction
The most diverse and mutable clinical manifestations occur from imbalance
The most effective clinical outcomes across all disease spectrums can result from normalization of gut function
List the seven aspects of digestion
Ingestion mastication Digestion pH HCl production Digestion pancreatic function Digestion bile function bile acids Brush border enzymes Intestinal epithelial function Nutrient absorption and assimilation
List the digestive enzymes and secretions
Salivary enzymes amylase lysozyme Gastric HCl pepsin Pancreatic enzymes Bile acids Intestinal brush border enzymes lactase cholecystokinin
Intestinal phase reflex direct digestive action review the steps
See slide 31 o Bryan gastro role barrier integrity
Why is celiac disease associated with increased fasting gallbladder volume and reduced gallbladder emptying in response to meals
Likely due to
Impaired meal induced release of gut hormones ie cholecystokinin
Secondary to loss of enterocyte mass (villous atrophy ) and increased somatostatin
IL 10 is increased in A atherosclerotic disease B physical exercise C ms D excessive TNF alpha
Il 10 is an anti inflammatory cytokine it is increased in physical exercise the rest of the answers are associated with inflammation
Hyperinsulinemia has been shown to have all of the following effects except A decreased HDL B increased small dense LDL particles C reduced CRP D increased serum triglycerides
Driving imbalance of met syndrome and you know low HDL is part of it , LDL become small, and drop in HDL elevates tri , but CRP does no reduce it is a response from the liver to increased inflammation
