GI Flashcards
Appendicitis
Inflammation of appendix
Appendicitis patho
Gut orgs invade appendix wall after lumen obstruction from:
- lymphoid hyperplasia
- faecolith
- filarial worms
Appendicitis Px
- Pain (umbilical -> RIF, McBurney’s point)
- Oedema
- Fever
- Tachycardia
- Anorexia
- N+V
- Constipation, maybe diarrhoea
- RIF tenderness, guarding
- Rovsing’s sign - pain greater in RIF than LIF when LIF pressed
- Psoas sign - pain on extending hip if retrocaecal appendix
- Cope sign - pain on flexion and internal rotation of hip (if appendix close to obturator internus)
Appendicitis DDx
Other causes of abdo pain - think systems (GI, urological, gynaecological…)
Appendicitis Ix
Bloods - raised WCC, CRP, ESR
USS
CT
Pregnancy test
Urinalysis (exclude UTI)
Appendicitis Mx
Laparoscopic appendectomy
IV ABs (metronidazole, cefuroxime)
Appendicitis Cx
Rupture -> peritonitis
Forms a mass
Abscess - after failure to resolve
Acute mesenteric ischaemia
Impaired blood flow gut (almost always SI)
AMI Causes
SMA thrombosis (commonest)
SMA embolism (eg AF)
Mesenteric vein thrombosis (hypercoagulable state)
Non-occlusive disease (low flow states, eg low CO)
AMI Px
- acute severe abdo pain
- no abdo signs
- rapid hypovolaemia (shock - pale skin, weak rapid pulse, reduced urine output, confusion)
AMI Ix
CT angiography - shows vessel blockage
Bloods (lactate), AXR
Laparotomy (cut into abdo wall)
AMI Mx
Resus - fluids, O2
ABs - IV gentamicin, metronidazole
IV heparin
Surgery to remove dead bowel
AMI Cx
Bacterial translocation across dying gut wall - septic peritonitis, SIRS
Chronic mesenteric ischaemia
chronic atherosclerotic disease of vessels supplying intestine
CMI cause
atherosclerosis - low flow of blood
CMI Px
- severe colicky post-prandial abdo pain (gut claudication)
- decreased wt
- upper abdo bruit (sounds), maybe PR (per rectum) bleeding
malabsorption, N+V, fear of eating, usually history of CVD
CMI Ix
CT angiography
CXR/AXR to exclude other stuff
CMI Mx
Stop smoking
Antiplatelet therapy
Surgery - angioplasty, stent
CMI Cx
malnutrition, reduced QoL from fear of eating
Ischaemic colitis
compromise of blood circulation supplying colon
IC patho
Causes - thrombosis, emboli, decreased CO, drugs (OCP), surgery, coagulation disorders
splenic flexure at risk - watershed between middle colic (SMA) and left colic (IMA)
IC Px
signs
shock
signs of CVD
symptoms
abdo pain, sudden onset, lower left side
bright red blood +/- diarrhoea
IC DDx
other causes of acute colitis, eg IBD
dysentry, diverticulitis
IC Ix
CT
Colonoscopy and biopsy
Barium enema maybe
IC Mx
Fluids
ABs
Surgical resection of bowel (could be gangrenous bowel)
mitigate risk factors - smoking, antiplatelet therapy etc
Diverticulitis
Inflammation of diverticulum (outpouching of gut wall)
diverticular disease - symptoms without inflammation
Diverticular disease patho
High intraluminal pressures (maybe lack of fibre), force mucosa to herniate through muscle layers of gut, usually near vessel entry sites
Causes - lack of fibre, obesity, smoking, NSAIDs
Diverticulitis patho
faeces obstructs neck of diverticulum, bacteria multiply, inflammation
Diverticular disease Px
altered bowel habit left sided colic, relieved by defecation nausea flatulence pain/constipation (severe)
Diverticulitis Px
As diverticular disease
pyrexia tachycardic tenderness, guarding severe pain symptoms of peritonitis
similar to appendicitis, but on left side
Diverticulitis Ix
CT colonography
Bloods - increased WCC, ESR, CRP
AXR, barium enema
Diverticular disease Mx
High fibre diet
antispasmodic - mebeverine
maybe surgical resection
Diverticulitis Mx
Fluids, ABs (ciprofloxacin, metronidazole)
Surgical resection
Diverticulitis Cx
perforation, fistula formation, intestinal obstruction, bleeding, mucosal inflammation, abscesses
Meckel’s diverticulum
outpouching of distal ileum
surgical removal
Oesophageal cancer
carcinoma of oesophagus
squamous cell carcinoma (SCC) or adenocarcinoma (AC)
Oesophageal cancer patho
SSC in upper 2/3, AC lower 1/3
Barrett’s: acid, stratified squamous epithelium -> simple columnar mucosa
often presents late in disease
oesophageal cancer causes
alcohol achalasia (reduced peristalsis) smoking obesity GORD
oesophageal cancer Px
signs
- lymphadenopathy
- hoarseness, cough
symptoms
- dysphagia, progressive (solids, then liquids)
- weight loss
- anorexia
- vomiting
- pain
oesophageal cancer Ix
endoscopy
barium swallow
CT/MRI/PET - stage tumour
oesophageal cancer Mx
chemo
resection
palliative
Benign oesophageal tumour
1% oesophageal tumours, slow growing
asymptomatic, dysphagia, pain, regurgitation
endoscopy
surgical removal
Gastric cancer
adenocarcinoma (epithelial tissue) of stomach
gastric cancer patho
Intestinal cancer - well formed, differentiated glandular structures
Diffuse - infiltrative, undifferentiated, worse prognosis
gastric cancer causes
smoking H.pylori dietary factors genetics pernicious anaemia - atrophic gastritis
gastric cancer Px
advanced, metastases (bone, brain, lung)
signs
- anaemia from blood loss
- jaundice (liver metastases)
- palpable shoulder lymph node
symptoms
- epigastric pain, dyspepsia (indigestion)
- N+V
- anorexia
- weight loss
- dysphagia if tumour in fundus
gastric cancer Ix
gastroscopy and biopsy
USS, CT, MRI, PET
FBC, LFT
gastric cancer Mx
surgical resection
chemo/radio
treat symptoms
SI tumours
rare, AC most common, maybe lymphomas
SI tumours Px
signs
- anaemia
- palpable mass
symptoms
- pain
- diarrhoea
- anorexia
- wt loss
SI tumours Ix
USS
endoscopic biopsy
CT
SI tumours Mx
radiotherapy
surgical resection
Colonic polyps
abnormal growth of tissue from colonic mucosa
adenoma/inherited
Colonic polyps Px
mostly asymptomatic
signs
- rectal polyps/masses
symptoms
- bleeding
- diarrhoea, abdo pain, mucous discharge
- obstruction - constipation, vomiting, peritonitis
colonic polyps Ix
colonoscopy with biopsy
CT/MRI
Genetic testing
Colonic polyps Mx
surgical removal
colorectal cancer
carcinoma of LI, usually AC
colorectal cancer patho
majority in distal colon
normal epithelium -> adenoma -> colorectal adenocarcinoma -> metastatic (to liver, lung, brain)
Genetics - familial adenomatous polyposis, hereditary nonpolyposis colorectal cancer
colorectal cancer RFs
increasing age, low fibre, sat fats, red meat, sugar, polyps, alcohol, smoking, obesity, UC, FHx, genetics
colorectal cancer Px
depends on location
signs
- anaemia (bleeding)
symptoms
- blood and mucus
- change in bowel habit
- diarrhoea/constipation
- wt loss
- abdo pain (right sided)
- thin altered stools
- tenesmus (feeling of incomplete defecation)
may present as emergency - obstruction
jaundice/hepatomegaly - liver metastases
colorectal cancer DDx
haemorrhoids, anal fissure, prolapse, diverticular disease, IBD, GI bleed
colorectal cancer Ix
CT colonoscopy and biopsy
FBC - anaemia
barium enema
MRI to determine spread
classify - Dukes, TNM