Gestational Trophoblastic Disease Flashcards
According to FIGO 2002 what are the classifications of GTD:
Hydatidiform mole
Gestational trophoblastic neoplasia
What are the spectrum of placental related tumors:
Molar
Non-Molar
In molar pregnancy give the characteristics of the chorionic villi:
Trophoblastic proliferation
Edema of the villous stroma
Avascular
What is the karyotype of complete H-mole:
Diploid, Paternal origin
What are the two types of diploid karyotype of complete H-mole:
46 XX (85%) both from father 46 XY - Dispermic fertilization
What is the malignant potential of complete H-mole:
15-20%
Does early evacuation of complete H-mole has role in lowering the risk of malignancy?
NO
This H-mole has some elements of fetal tissue:
Partial H-mole
Histology: Slowly progressive swelling of stroma of avascular chorionic villi
Partial H-mole
What is the karyotype of partial H-mole:
Triploid (Diandry)
One maternal and Two paternal haploid sets of chromosomes
What are the karyotypic types of triploidy in partial H-mole:
69 XXX
69 XXY
69 XYY
What are the consequences of the triploid karyotype:
Fetus is NONVIABLE with MULTIPLE MALFORMATIONS or SEVERE GROWTH RESTRICTION
What is the malignant potential of a partial H-mole:
1-5%
The persistent disease of a partial H-mole is a:
Choriocarcinoma but very rare
What test gives us an idea that there is also an increased of persistent disease:
Increased POSTEVALUATION in B-HCG levels
