Gestational Condition Flashcards
Hypertension in Pregnancy: Significance & Incidence
- Preeclampsia complicates approx. 5-10% of all pregnancies
-
HTN disorders of preg are the most common medical complication reported during preg
> hemorrhagic/SI are 2nd & 3rd - Significant contributor to maternal & perinatal morbidity & mortality
Gestational Hypertension
- Develops after 20th wk of preg w/out proteinuria
- Need more than 1 HTN reading
Chronic Hypertension
& risk for, & fetal effects
- HTN before pregnancy or diagnosed before 20 wks
-
Risk for
> placental abruption
> superimposed preeclampsia: development of preeclamp from HTN
> incrd perinatal mortality -
Fetal Effects
> growth restriction
> preterm birth
Preeclampsia
-
HTN & proteinuria develops after 20wks
or -
HTN w/ end organ damage
> renal/liver
Eclampsia
- Seizure activity or coma in women diagnosed w/ preeclampsia
-
No previous hx
> or pre-existing patho of seizure disorder - Eclamptic seizures can occur before, during, or after birth
Chronic HTN w/ Superimposed Preeclampsia
- A sudden incr in blood pressure tht was previously well-controlled
- New-onset proteinuria or a sudden & sustained incr in proteinuria in a women known to have proteinuria before conception or early in pregnancy
Preeclampsia - Pathophysiology
- Disruptions in placental perfusion & endothelial cell dysfunctions
-
Placental itching (spasm)
> = small baby -
Generalized vasospasm
> incrd risk of clots - Spiral arteries don’t remodel to allow for incrd blood flow
-
Reduced kidney perfusion
> protein in urine
> generalized edema
Preeclampsia - Etiology
S/S only develop during pregnancy and disappear after birth
Preeclampsia - Risk Factors
- Fam hx
- Multifetal pregnancy
- African-American race
- Obesity
- 19-40yrs
- Any pre-existing medical or genetic conditions
Preeclampsia: HELLP Syndrome
-
Lab diagnostic variant of severe preeclamp involves hepatic dysfunction, characterized by:
> Hemolysis (H)
> Elevated liver enzymes (EL)
> Low platelets (LP)
Preeclampsia: HELLP Syndrome - Associated w/ Incrd Risk For
- Pulm edema
- Renal failure
- Liver hemorrhage or failure
-
Disseminated intravascular coagulation (DIC)
> use up all clotting factors; bleed out of all holes - Placental abruption
- Acute resp distress syndrome
- Sepsis
- Stroke
- Fetal & maternal death
Identifying & Preventing Preeclampsia
LILI LUK
-
Physical Examination
> dependent, pitting edema
> DTR (clonus): suppose to be negative
> blurred/double vision
> RUQ pain: liver ischemia
> listen to lungs/HR: pulm edema
> SOB -
Lab Tests
> urine output (oliguria)
> kidney labs (Cr/proteinuria)
> low platelets
> incrs factor 8
> liver func tests
> lipids incrd
> incrd Hct
Mild Gestational HTN & Mild Preeclampsia
treatment
diet
-
Treatment:
> BP control
> May have some restriction
> Maternal/fetal assessment -
Diet
> don’t reduce salt
Severe Gestational HTN & Severe Preeclampsia
cure
med
-
Cure
> delivery -
Drug used during delivery to prevent eclampsia
> magnesium sulfate: prevent & treat a seizure - severe GHTN & preeclamp put pregnancy at greater risk for complications
> control BP
Magnesium Sulfate
how to admin
therapeutic lvls
excretion
- Drug of choice for prevention & treatment of eclampsia
-
Administered almost excusively IV
> 4-6gram loading dose over 15-20mins
> followed by maintenance dose of 2gram/hr after delivery
> big bore IV -
Therapeutic lvls
> 4-7mEq/L -
Excreted by kidneys
> if compromised, lvls will rise
> watch I&Os for toxicity
Magnesium Sulfate - Adverse Effects
- Warming
- Flushing
- Diaphoresis
- IV site irritation
- may need Pitocin to help contract since mag causes relaxation
Magnesium Sulfate - Mild Toxicity
- Appears drunk:
- Lethargy
- Muscle weakness
- Dcrd DTRs
- Double vision
- Slurred speech
- draw labs, watch I&Os
Magensium Toxicity - Severe Toxicity
- Maternal hypotension
-
Bradycardia
> dcrd HR -
Bradypnea
> dcrd RR - Cardiac arrest
Magnesium Toxicity - Managing Toxicity
-
Discontinue infusion
> priority - Notify HCP
-
Administer Calcium Gluconate
> antidote