Geriatrics & Cardiology Flashcards
What are the 3 D’s of cognitive impairment?
- 3 Neurological causes?
- 3 Psychiatric causes?
- 3 “Classics”?
3 D’s of Cognitive Impairment
1. Dementia
2. Delirium
3. Depression
What is Mild Cognitive Impairment?
= Generally defined by the presence of memory difficulty and objective memory impairment but preserved ability to function in daily life.
Compare Delirium and Dementia - 9 points?
Delirium - Delirium is a neurocognitive disorder characterized by impairments in attention and awareness (reduced orientation to the environment), as well as other cognitive disturbances (e.g., in memory, language, or perception).
Dementia - An acquired disorder of cognitive function that is commonly characterized by impairments in memory, speech, reasoning, intellectual function, and/or spatiotemporal awareness.
Define Delirium.
- 5 Characteristic Features?
- 5 DSMV Criteria?
- 2 Additional features?
DEFINITION: An acute organic mental syndrome characterised by:
1. Global cognitive impairment
2. Reduced conciousness
3. Disturbed attention
4. Psychomotor activity
5. Sleep-wake cycle disturbance
Prevalence of Delirium - Med vs. Surg?
List the common causes of delirium.
- 6 top ones?
- By category?
Causes:
1. Sepsis
2. Hypoxia
3. Biochemical disturbances
4. Constipation
5. Dehydration
6. Restraints
List 8 drugs that are believed to cause or prolong delirium or confusional states?
Drugs and drug groups that commonly cause or contribute to delirium
1. Alcohol and illicit drugs (eg cannabis, methamfetamine)
2. Anticholinergics
3. Corticosteroids
4. Dopaminergic drugs (eg levodopa, dopamine agonists, catechol-O-methyltransferase [COMT] inhibitors)
5. Opioids
6. NSAIDs
7. Propranolol and sotalol
8. Psychotropics—especially benzodiazepines.
Causes of Delirium:
- 5 Metabolic?
- 3 Infection?
- 9 Drugs/Toxins?
- 7 Cardiorespiratory?
- 7 Other?
I WATCH DEATH: Infection, Withdrawal, Acute metabolic disorder, Trauma, CNS pathology, Hypoxia, Deficiencies, Endocrine, Acute vascular, Toxins/drugs, and Heavy metals are the major causes of delirium.
5 Predisposing Factors of Delirium?
6 Precipitating Factors for Delirium?
Predisposing Factors:
1. Dementia
2. Impaired ADLs
3. Age >80
4. Severe Illness
5. Visual & hearing impairment
Precipitating Factors:
1. Intercurrent illness
2. Infections
3. Metabolic disturbances
4. Hypotension
5. Etoh
6. Intracranial pathology
Clinical features of Delirium?
The main symptom is an acute (hours to days) alteration in the level of awareness and attention.
Other features may include:
1. Disorganized thinking
2. Illusions
3. Hallucinations (mostly visual)
4. Cognitive deficits (e.g., memory)
5. Reversal of the sleep-wake cycle
6. Emotional lability
7. Agitation, combativeness
8. Alterations in psychomotor activity may occur.
The severity of symptoms fluctuates throughout the day and worsens in the evening (termed sundowning).
Symptoms are reversible; their duration and severity depend on the underlying illness.
How is Delirium diagnosed?
- 4 Components of CAM?
Delirium is diagnosed clinically. Further studies should be conducted to determine the underlying etiology.
- DSMV (more for research)
- Confusion Assessment Method (CAM) = simple, higher inter-rater reliability and sensitivity, high specificity.
What are 2 bedside tests of attention?
Which investigations would you order for a patient with suspected delirium?
Routine laboratory studies
The following studies are recommended in all patients with a new presumptive delirium diagnosis.
1. Complete blood count
2. Serum glucose
3. Electrolytes
4. Urinalysis: abnormalities related to UTI (e.g., pyuria, bacteriuria) or renal failure (e.g., urinary casts)
What is the 4AT test? 4 components?
4AT = more sensitive but less specific than CAM
List 17 first line investigations to order when determining the aetiology of delirium?
List 4 second line investigations to order when determining the aetiology of delirium?
List 4 third line investigations to order when determining the aetiology of delirium?
Describe an approach to the assessment and management of delirium?
- List 8 support measures?
Evaluation & Management
1. Cognitive evaluation (MMSE, CAM, Collateral history)
2. Search for underlying aetiology (Note neuroimaging and LP are only indicated in <5%)
6 ways to try to prevent delirium/complications?
- Early detection & treatment of complications
- Correct fluid and electrolyte abnormalities
- Stopping unnecessary meds
- Treat severe pain
- Regulation of bowel & bladder function
- Early mobilisation/rehab
- Over one-third of cases of delirium can be prevented with nonpharmacological strategies.
- ## Uninterrupted sleep is particularly important in patients with delirium, who may experience a worsening of neuropsychiatric symptoms in the evening and at night known as sundowning.
When are pharmaceuticals indicated in the management of delirium? What would you prescribe? Complications of these meds?
Indications - Patients with severe agitation which causes:
1. Interruption of essential medical treatment (eg. intubation)
2. Pose safety hazard to staff, other patients, themselves
- Avoid antipsychotics in patients with underlying alcohol withdrawal or benzodiazepine withdrawal (due to the risk of seizures) and in patients at high risk for QTc prolongation (due to the risk of torsades de pointes).
- Cholinesterase inhibitors have not been shown to be effective in the prevention or treatment of delirium. However, patients requiring long-term treatment cholinesterase inhibitors can continue to use them.
- Benzodiazepines are deliriogenic. Do not treat delirious patients with benzodiazepines unless the delirium is due to alcohol or benzodiazepine withdrawal.
List 4 non-pharmaceutical measures to manage agitation in a delirius patient?
13 Do’s of Delirium Management?
- 5 Dont’s?
- 4 Tips?
TIPS
1. Patients often have multiple causes of delirium
2. Normal tests do not necessary exclude delirium
3. Beware the undiagnosed head injury as a cause of delirium - esp. in NOAC patients, always question an informant about falls, head injury or other trauma
4. Examine patient carefully for signs of trauma
What are the 3 types of delirium?
List 5 reasons why delirium is an important condition to prevent?
- Hyperactive delirium: the patient has agitation, restlessness, hallucinations or delusions.
- Hypoactive delirium: the patient is quiet and withdrawn. Hypoactive delirium is the most prevalent form of delirium but is not as obvious and often missed.
- Mixed delirium: the patient alternates between hyperactive and hypoactive states.
What causes a fall? 3 Threats?
- 3 Consequences of falls?
- 3 Costs of falls?
Falls usually occurs when a threat to the normal homeostatic mechanisms that maintain postural stability is superimposed on age-related declines in balance, ambulation, and cardiovascular dysfunction.
Threat:
1. Acute illness
2. Environmental Stress
3. Unsafe walking surface
List 11 Risk factors for falls?
- Age
- Female
- Past fall
- Cognitive impairment
- Lower limb weakness
- Balance disturbance
- Psychotropic meds
- Arthritis
- Past CVA
- Orthostatic hypotension
- Dizziness
Why worry about falls in the elderly? (5)
- The risk of falls increases with age.
- Falls are the leading cause of unintentional injury in older Australians.
- Falls are not only associated with physical injury; they can cause loss of confidence and fear of falling, resulting in the person becoming less physically active.
- Falls are associated with loss of functional independence and quality of life.
- Falls are associated with an increased risk of premature admission to residential care and of mortality.
5 Complications of Falls?
- Post fall anxiety (fear of falling) is common, impacting on physical and social function.
- Immobility related injuries include muscle wasting, rhabdomyolysis, pressure sores.
- Wrist fractures are more common <75 years, while those >75 suffer more hip and pelvic fractures.
- Falls account for ~40% of all injury related deaths.
- People living in residential care settings are at much higher risk of falls and falls-related injuries than those living in community settings.
- List 10 Intrinsic Risk factors for falls?
- List 8 Extrinsic risk factors for falls?
- List 3 Precipitating Events for falls?
Precipitating Events
1. Trips & Slips
2. Acute medical illness
3. Change in medication
4. Dizziness
Describe a risk factor model for falls in the elderly?
- 3 Risk factors with increased risk of falls with major injury?
- Past history of a fall
- Lower-extremity weakness
- Age
- Female sex
- Cognitive impairment
- Balance problems
- Psychotropic drug use
- Arthritis
- History of stroke
- Orthostatic hypotension
- Dizziness
- Anemia
Factors associated with increased risk for falls with major injuries (fracture, dislocation, or laceration requiring suture) include:
1. Fall associated with syncope
2. History of previous fall with injury
3. Decreased executive function, measured by Trail Making B time
Causes of Falls:
- 3 Age related functional decline?
- 5 Environmental factors?
- 7 Neurological?
- 4 Cardiovascular?
- 3 GIT?
- 4 Metabolic?
- 3 Urogenital?
- 3 MSK?
Age related functional decline
1. Visual
2. Proprioceptive
3. Vestibular
Environment
1. Footwear
2. Home modifications
3. Behaviour
4. Safety devices
5. Social integration
- Why do people living with cognitive impairment fall? (4)
- What effect does location have on the risk factors for falls?
- Impaired cognition
- Poor attention
- Reduced safety awareness and decision making capacity
- Fear of falling
What are 6 Mechanisms of falls?
- Syncope/Hypotension
- Seizure
- Dizziness/Balance
- Gait disturbance
- Pain/Weakness
- Mechanical fall
List 7 Medications that can contribute to falls?
Falls - Medications
1. Antihypertensives & Cardiac
2. Antidepressants
3. Antipsychotics
4. Benzodiazepines
5. Levadopa
6. Narcotics
Toxins - eg. Alcohol
Make you drowsy, hypotensive, hyponatramic & seizure
List 8 functional impairments that can contribute to the risk of falls?
**Functional Impairment **
1. BP regulation
2. Central processing
3. Gait
4. Neuromotor function
5. Postural control
6. Proprioception
7. Vestibular
8. Vision
What questions should be asked on history taking regarding a fall?
If Patient presents with a fall from vertigo:
- What are 4 differentials?
- Qs about Timecourse? (3)
- Qs about Symptoms? (3)
- Qs about Other features? (4)
List 7 Medications associated with an increased risk of falls?
Medications associated with increased risk of falls
Psychoactive medications and vasoactive/cardiovascular medications are associated with an increased risk of falls.
1. Benzodiazepine (increased risk ~ 48%)
2. Antipsychotics
3. Antidepressants (including tricyclic and SSRIs)
4. Antiepileptics
5. Opioid analgesics
6. Diuretics
7. Antihypertensives including calcium channel blockers, beta blockers, prazosin, moxonidine etc.
Benzodiazepines are a very important contributor to falls, but discontinuation is often difficult because of patient dependency on these medications.
Outline a framework for history taking of a fall.
- History of presenting complaint?
Outline a framework for history taking of a fall.
- Systems Enquiry?
Outline a framework for history taking of a fall.
- Past Medical History?
- Social History?
Social history
1. Alcohol intake
2. Support at home – friends/family and carers
3. Mobility – use of mobility aids and when (e.g. zimmer frame downstairs only)
What are the 9 components of an examination for a falls patient?
Outline a flowchart for falls evaluation.
What are 5 Ways to test balance?
Outline at least 5 measures to prevent falls?
Measures to prevent falls and thereby reduce the incidence and severity of fractures include:
1. Improving vision
2. Adjusting drug therapy if possible (eg drugs causing sedation, altered gait or postural hypotension).
3. Minimising household risks (preferably under the guidance of an occupational therapist).
4. Providing aids for daily living (eg walking aids, rails).
5. Minimising periods of immobilisation
promoting exercise to maintain mobility, balance and strength.
List 5 Falls Injury Prevention strategies?
- Osteoporosis treatment can improve bone integrity.
- Strength and balance training: There is evidence that strength and balance retraining in postmenopausal women decreases both falls and vertebral crush fractures.
- Hip protectors: Hip protectors may decrease hip fracture rates in frail and institutionalised elderly, however, there is no evidence supporting their use in fitter, community dwelling elderly. Compliance is a major issue.
- Anticoagulants: The risk of bleeding complications following a fall is increased in patients on anticoagulants. Rationalisation of therapy requires consideration of the risk and benefits, undertaken on a case-by-case basis.
- Falls alarms: Falls alarms may prevent complications of falls with a long lie. Compliance may affect usefulness of alarms.
How does normal micturition occur?
Normal micturition occurs when bladder contraction is coordinated with urethral sphincter relaxation. The central nervous system inhibits voiding until the appropriate time and coordinates and facilitates input from the lower urinary tract to start and complete voiding. The sympathetic system contracts the smooth muscle sphincter through alpha-adrenergic fibres from the hypogastric nerve. The parasympathetic nervous system contracts the bladder detrusor muscle through cholinergic fibers.
What is the incidence and burden of urinary Incontinence?
INCIDENCE
- 15-30% community dwelling
- 30% hospitalised
- 50% long term care
What are 6 major processes that control continence?
- Mobility – to get to the toilet in adequate time
- Cognition – to recognise the need to toilet and where to void appropriately
- Intact lower urinary tract – to allow adequate storage and elimination of urine
- Neurology – to coordinate the appropriate signals between bladder and brain to generate an appropriate voiding response
- Environment – Appropriate access to toilets or aids with availability of carers if required.
- Mental health – Anxiety and depression can impact on many bladder related symptoms.
Is Incontinence a diagnosis?
= NO
- Incontinence is a symptom.
- Incontinence is abnormal at any age.
- At no age does it affect the majority of individuals.
- Even with severe dementia not all people are incontinent.
- New incontinence must be investigated.
What are 6 things Urinary Incontinence predisposes a person to?
Urinary Incontinence predisposes to:
1. Rashes
2. Pressure Sores
3. Urinary tract infections
4. Falls - slipping on wet floor/rushing
5. Fractures
6. Increased risk of institutionalised care - carer can no longer look after them at home.
What are 12 Risk factors for Urinary incontinence?
Risk factors vary by type!
1. Age is an important risk factor for both prevalence and severity of incontinence
2. Women > men
3. Obesity: 3X risk
4. Obstetric: parity and mode of delivery (vaginal>caesarian)
5. Hysterectomy
6. Family history
7. Smoking
8. Constipation
9. Diabetes
10. Depression
11. Dementia
12. Neurological conditions
How can Urinary Incontinence be classified?
- Outline the 4 types?
- Transient (pregnancy, UTI, in a hospital and can’t physically get there) or established.
- Type of Incontinence – Urge (key in the door), Stress (raised intraabdominal pressure – cough etc. Common post-partum = sphincter), Overflow (enlarged prostate, fecal impaction & don’t empty bladder out and its very stretched)
- Neurogenic or Non-neurogenic
List the causes of Transient Urinary Incontinence - DIAPERS?
- 7 Pharmaceuticals?
- 2 causes of excessive output?
Pharmaceuticals
1. Anticholinergics
2. Alpha agonists (men)
3. Alpha antagonists (women)
4. Calcium channel blockers
5. ACE Inhibitors (cough)
6. Diuretics
7. Sedatives (and alcohol)
Excessive output – high calcium, high blood sugar
What are the 4 Pathophysiological mechanisms of Established Incontinence?
Pathophysiological mechanisms of Established Incontinence:
1. Detrusor overactivity
2. Detrusor underactivity
3. Obstruction
4. Outlet incontinence
Each can either be neurogenic or non-neurogenic
Which types of Urinary incontinence are more common in men vs. women?