Geriatrics 👴🏽 Flashcards
3a
What is dementia?
Dementia is a condition that causes progressive and irreversible impairment in memory, cognition, personality and communication
What is the most common type of dementia?
Alzheimer’s
What type of dementia is associated with halluciations?
Lewy body dementia
What kind of decline does vascular dementia show?
Stepwise decline
What is the pathophysiology of lewy body dementia?
Lewy bodies build up in the substantia nigra, paralimbic and neocortical areas
What are lewy bodies?
Alpha-synuclein cytoplasmic inclusions
How does lewy body dementia differ from Parkinson’s?
Dementia usually occurs before any parkinsonism (both within a year)
What are the features of lewy body dementia? (3)
Parkinsonism Visual hallucinations Progressive cognitive impairmentREM sleep behavioural disturbance
How does cognition change day to day in lewy body dementia?
Cognition is fluctuating
What investigation can be carried out to help diagnose lewy body dementia?
DaTscan
Why may a DaTscan be performed in someone with suspected lewy body?
To differentiate from Alzheimer’s
What is the first line medical management of lewy body dementia?
AcetylCholinesterase inhibitor eg donepezil
What is the first line management of lewy body dementia?
Supportive treatment
What kind of medications should be avoided in patients with lewy body dementia?
Antipsychotic medications
Trisomy 21 leads to an increased risk of which type of dementia?
Alzheimer’s
What are the risk factors of developing Alzheimer’s? (3)
Increasing age
Family history
Genetics
Down’s syndrome
Caucasian ethnicity
What are the histopathological changes seen in Alzheimer’s disease? (3)
Neurofibrillary triangles Beta amyloid plaques Cortical atrophy
What is a potentially reversible cause of dementia?
Normal pressure hydrocephalus
What is the first line medical management of Alzheimer’s?
Acetylcholinesterase (AChE) inhibitors
Donepezil, galantamine and rivastigmine
What is the second line medical management of Alzheimer’s?
Memantine (for mild to severe disease)
What drug class is memantine?
NMDA receptor antagonist
What other management options should be offered to people with Alzheimer’s?
Group therapies - cognitive stimulation therapy Activities to promote wellbeing
What is vascular dementia caused by?
Vascular dementia is secondary to cerebrovascular disease
What are the risk factors for vascular dementia? (5)
Hypertension AF Diabetes History of stroke History of TIA Smoking ObesityFamily history of stroke or TIA