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PHM 704- Geriatrics > Geriatric PK/PD: Elimination > Flashcards

Geriatric PK/PD: Elimination Flashcards

1
Q

Renal changes with again

A

Decreased volume and weight
Decreased renal blood flow
Glomerular function
Decreased tubular function

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2
Q

What formula do you use to calculate CrCl?

A

Cockcroft-Gault

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3
Q

Renal drug clearance: tubular function

A

organic base transport doesn’t appear to be altered, organic acid transport appears to decline with age

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4
Q

Drugs with a significant renal component to elimination

A

hydrophilic beta-blockers
ACEIs
Vanco
Gabapentin
AGs

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5
Q

Drugs with pharmacologically active metabolites

A

amoxapine, desipramine, metoprolol, risperidone

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6
Q

Active metabolites with detrimental effects

A

norpropoxyphene (D/C’ed, off market), hydroxyaminodapsone, normeperidine

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7
Q

Drug that shunts CL from renal to metabolic pathways

A

Theophylline

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PHM 704- Geriatrics (15 decks)

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