Geriatric Pharm Flashcards
Aging and geriatric care
Prevention
Treatment of common disease
CDC recommendations for vax for elderly
Above 70
- influenza
- pneumococcus
- shingles
Most common diseases in the geriatric population
HTN DM hyperlipidemia OA Cancer
Geriatric syndromes and conditions
Falls Polypharmacy Cognitive impairment-delirium and dementia Urinary incontinence Sleep disorders Elder abuse and neglect
The prescription of multiple medications using various thresholds
Polypharmacy
4 types of primary sleep disorders in the elderly population
Insomnia
Sleep disorderred breathing due to OSA
Restless leg syndrome
Periodic leg movements in sleep
Fundamental pathways of drug movement
Absorption
Distribution
Metabolism
Excretion
(Pharmacokinetics)
Absorption
Minimum one effected by age
Decrease absotopion surface splanchnic blood flow
Increased gastric pH
Altered GI motility
Distribution and age
- decreased in total body water, lean body mass, and serum albumin
- increased fat
- altered protein bindgin
Metabolism and age
Decreased liver blood enzyme, enzyme activity, enzyme inducibility
Excretion and age
Decreased in renal blood flow, glomerular filtration rate, tubular secretory function
Tissue/receptor sensitivy in age
Alterations in receptor number, receptor affinity, second messenger function, and cellular and nuclear response
What is affected the most in elders in terms of pharmacokinetics
Absorption
Drug dosing for elderly
Start with the smallest amount possible and increase from there if needed
Aspirin side effects
Blood loss
