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Gastrointestinal Pharmacology > GERD Pharmacology > Flashcards

GERD Pharmacology Flashcards

1
Q

Is magnesium hydroxide metabolized?

A

No

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2
Q

What are some dangerous symptoms of magnesium hydroxide poisoning?

A

Cardiac arrhythmias, coma and cardiac arrest

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3
Q

What is the lethal dose of magnesium hydroxide?

A

LD50=8500 mg/kg

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4
Q

What are some common side effects of magnesium hydroxide?

A

Drowsiness, flushing

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5
Q

Daily use of magnesium hydroxide can result in?

A

Fluid and electrolyte disturbances

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6
Q

Magnesium hydroxide is contraindicated in which type of patients?

A

Pregnant woman who are about to deliver, people with kidney disease or renal failure, abdominal pain, myocardial damage, heart block, etc

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7
Q

Combination of magnesium hydroxide with which other drug can decrease the absorption of rate of these drugs?

A

Aluminum hydroxide

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8
Q

With which drugs can magnesium hydroxide react with?

A

Digoxin, dicoumerol and cimetidine

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9
Q

Which drug can increase the absorption of ibuprofen?

A

Magnesium hydroxide

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10
Q

Magnesium hydroxide can decrease the absorption of which drugs?

A

Penicallamine, biphosphates, ketoconazole, quinolones and tetracycline

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11
Q

Which tablets can be prematurely released when taking magnesium hydroxide?

A

Enteric coated tablets

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12
Q

Cimetidine and ranitidine are…

A

H2 antagonists

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13
Q

Cimetidine and ratinidine are used for…

A

Acid reflux disorders, peptic ulcer disease, heartburn, and acid indigestion

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14
Q

What is the mechanism of action of H2 antagonists?

A

Binds to H2 receptors located on the basolateral memebrane of the gastric parietal cell blocking histamine effects

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15
Q

Cimetidine is metabolized by?

A

CYP450

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16
Q

People are concerned about using cimetidine because…?

A

Interference with vitamin D metabolism and endocrine function

17
Q

Metoclopramide is a…

A

Dopamine antagonist

18
Q

Metoclopramide is used for..?

A

GERD, nausea and vomiting and for increasing gastric emptying

19
Q

What is the pharmacological effect of metoclopramide?

A

Inhibits gastric smooth muscle relaxation produced by dopamine therefore increasing cholinergic response of the GI smooth muscle

20
Q

What is another action of metoclopramide?

A

Accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of the antrum

21
Q

Metoclopramide increases the resting pressure of the..

A

LES

22
Q

Metoclopramide increases the amplitude of…

A

Esophageal peristaltic contractions

23
Q

Cisapride is used for what conditions?

A

Nocturnal heartburn due to GERD

24
Q

What is one important adverse effect of cisapride?

A

long QT syndrome

25
Q

Which open technique is the most used one when it comes to treating GERD?

A

Nissen

Gastrointestinal Pharmacology (3 decks)

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