GER and Celiac Disease Flashcards

1
Q

GER: what is it?

A

-Transfer of gastric content into the esophagus
-1 in 700 children have significant problem with GER
-Etiology: unknown
>transient relaxation of LES: may go up or down
>delayed gastric emptying: sits too long, doesn’t empty, relfux
>Prematurity: more premature baby gets GER
>Gastric distention (when not burping)
>Anything that increase abd pressure (ex: coughing)
>Certain Meds
>Gastric tube in place increases changes for GER

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2
Q

Differences between GER and GERD?

A
  • *GERD- adulthood
    - “D” stands for disease: start to see permanent damage (symptomatic)
    - Some kids with GER can develop GERD
  • *GER- common in kids, especially in babies
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3
Q

If the stomach content reflux back up, what happens?

A

Reflux up to the esophagus and erodes the esophagus (Big Concern!): can cause irritations

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4
Q

What are the clinical manifestation of GER?

A
  • *Passive REgurgitation and emesis (most common symptom!)
  • poor weight gain (not keeping food down)
  • Heme-positive emesis or stool (blood in stool, come from esophagus)
  • irritability
  • Heart burn (bc of esophageal irritation)
  • Anemia (not taking enough iron)
  • Gagging/choking after feeds
  • Recurrent pneumonia (constant regurg, increase agitation)
  • Premies: apnea, bradycardia
  • Otitis Media (middle ear infection): has to do with fluid regurging back
  • Burning sensation: anywhere along esophagus to stomach
  • Bronchospasm: aspiration pneumonia (CONCERN!)
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5
Q

Diagnostics for GER

A

-History: Hx of respiratory problems, may be aspirating and parents don’t realize
-Exam: looking for frequent vomiting
-Can Briac the stool (test it)
-Diagnostic studies
>Barium Swallow: look for reflux of barium in esophagus
>Upper GI series: distinguishes GER and pyloric stenosis
>Esophageal pH monitoring/probe: probe in place above LES for 24 hours, take continuous reading w pH in esophagus, can also be used for biopsy
-Need help from parents to calm crying baby
-EGD

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6
Q

Normal pH levels

A

In esophagus: 4-6
In Gastric: 1.9 (more acidic)

decrease pH = increase gastric content = immediate are is more acidic

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7
Q

Treatment and Nursing Care of GER

A

-Small, frequent feeds, burp (don’t over distend stomach)
-Continuous NG-esp if severe GER and FTT (still small feeding)
-Thickened feedings: can thicken breast milk, thicken with rice cereal (1TBS to ! oz.)
>when doing calorie count, consider the TBS of rice cereal
-Frequent burping
-Positioning: turn to side, don’t want prone
-weight/Harness

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8
Q

Which side to you position the patient for GER and why?

A

help increase chance of gastric emptying, put them on their right side bc of gravity

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9
Q

Why do you thicken the fluids for GER pts?

A

because gravity pulls the thicken content down and tends to stay down
-sometimes it can increase coughing (be careful bc it’s going to open LES. Make sure they are not aspirating

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10
Q

Treatment: Medication for GER

A
  • H2 inhibitors: cimetadine (Tagamet (help to treat mild esophagitis, inhibits hydrogen ion, make it less acidic), Ranitidine (zantac), Famitodine (Pepcid)
  • Omeprazole (Prilosec or Prevacid): proton pump inhibitors (more potent gastric acid inhibitor or H2, keeps acid down, give 30 min before meal)
  • Metoclopramide (Reglan): often used in kids, promotes esophageal parastalsis, increase gastric emptying = decrease reflux = increase tone of LES
  • Gisapride (Propulsid): increase LES tone, help w/ gastric emptying, not used often bc cause cardiac arrhythmia’s (SE)
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11
Q

Treatment and Prognosis for GER

A
  • Surgical Intervention: Nissen Fundoplication- wrap gastric fundus around lower esophagus, distal esophagus gets smaller and takes more pressure to open LES
    • Not REVERSIBLE!
    • Used when everything else fails!
  • Prognosis: most cases-mild and resolve- 1y/o (can take up to 12-18 months, some kids take up full 18 mo, tell parent not to worry)
  • Most can manage with medical tx
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12
Q

Parent Teaching with GER

A

Avoid foods that:

  • Decrease LES tone: chocolate, tomato, carbonated fluids
    * *if breastfeeding-mom needs to aboid those food too!
  • Increase gastric acid secretions: avoid spicy food, citrus, fruit juice
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13
Q

Complications of GER

A
  • esophageal strictures: for persistent esophagitis
  • recurrent respiratory distress: for aspiration problem
  • FTT
  • Aspiration Pneumonia
  • Don’t forget esophageal erosion
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14
Q

Celiac Disease: What is it?

A

-Gluten induced enteropathy aka celiac sprue
-Malabsorptive syndrome with a defect in metabolism of gluten which cause impaired absorption of fat and nutrients
-MOST COMMON 1-5Y/O (could be diagnose as young as 9 mo.)
>why? has to do with what foods were introduced and when
>Rice is ok
>Beans, pastas, oats, white bread- takes a few months to see s/s (will see damage done to the villi)
-More adults are diagnosed with this

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15
Q

Etiology of Celiac Disease

A

-Exact etiology is unknown
-Believe it is:
>inborn error of metabolism
>autoimmune process- gluten acts like an antigen and destroy intestinal mucous
*PERMANENT intolerance to wheat, rye, barley oats (ex: gravy, cake, beer other grains)
>Think it is an allergic rx to Gliadin component of gluten

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16
Q

Pathophysiology of celiac disease: Gluten

A

-Gluten has 2 portions
>Glutenin (good)
>Gliadin (Bad): pt with this disease has an intolerance for Gliadin portion
-With Celiac Disease
>intolerance for Gliadin portion
>found in wheat rye, barley oats
-Gliadin- not fully digested so you end up with accumulation of glutamine (which is the one that is going to do the damage)

17
Q

Pathophysiology of celiac disease: Result

A

-glutamine is toxic to intestinal mucosal cells
-villi become damaged:
>decreases in #’s
>atrophy
-can decrease intestinal absorption by 95% (weight loss, FTT)

18
Q

Clinical Manifestation of Celiac Disease

A
  • STEATORRHEA (fatty poop): also found in cystic fibrosis, foul smell, greasy, distinctive
  • general malnutrition: tends to progressive
  • abdominal distention
  • Vit deficiencies
  • FTT (organic)
  • Chronic diarrhea
  • Muscle wasting (esp. buttocks and extremities)
  • Anemia
  • LE edema
  • Anorexia
19
Q

Vit Deficiencies causes what?

A
  • Decrease in protein can lead to peripheral edema bc protein draw in water and with low protein, water escape into interstitial space causing edema
  • decrease vit D and calcium: causes osteoporosis
  • decrease iron and folic acid: anemia
  • problem absorbing Vit K: can cause bleeding, bruising, and decrease clotting
  • decrease carb absorption: no energy
  • decrease B12: part cause of anemia
20
Q

Abdominal distention and muscle wasting with celiac disease

A
  • problems with metabolism = end up with bloating and gas distention
  • tend to develop lactose intolerance, which also contributes to gas distention to the colon
  • typical with malnutrition
21
Q

Celiac Disease: Diagnostics

A
  • sweat chloride test to rule out Cystic fibrosis bc of steatorrhea
  • Jejunal biopsy: villous atrophy (Bx small bowel to confirm the mucosa and decrease # of flatten villi
  • Initiate gluten free diet: remission of symptoms (give gluten free, then put gluten back into diet to see if gluten is the problem
22
Q

Celiac Crisis

A
  • profuse, watery diarrhea = severe dehydration, shock, metabolic acidosis, electrolyte imbalance
  • Precipitating factors: gluten in diet, psychological stress, **anticholinergic drugs (OTC drugs): mimic SNS, so when it does it relaxes smooth muscle and GI muscle and decrease blood supply to gut and damage villi
23
Q

Celiac Treatment

A

-Restore F&E/AB balance
-Eliminate or minimize gluten from diet
-Dietary Management:
>eliminate wheat, rye, barley, oats
>Supplements of folic acid, iron, and fat-soluble vitamins
-REMEMBER: We can’t fix this, we can only control this!!!