Georgette’s Flashcards
Benefits of Lithium treatment
Gold standard for treating manic episodes
Neuroprotective
Antisuicidal effect
Normal serum values for lithium
0.5 to 1.2 mEq per liter
Common Baseline labs before initiation with lithium
Thyroid panel (Hyperthyroid can appear as mania)
Serum creatinine (0.6 to 1.2 mg/dL)
BUN (10 to 20 mg/dL)
Urinalysis (Large amount of protein in urine (+4) May indicate kidney disease
Pregnancy test (12 to 51 years of age are considered child bearing)
ECG for clients >than 50
Clinically significant side effects of lithium
Hypothyroidism
Course hand tremors with toxicity
Maculopapular rash
Diarrhea, vomiting, cramps, anorexia
Polyuria with related polydipsia
T-wave inversion
Leukocytosis
Carbamazepine (Tegretol) Black box warning for
Agranulocytosis (low WBCs) and Aplastic anemia (deficiency of all types of blood cells)
pallor, fatigue, headache, nose bleeds, bleeding gums, skin rash, shortness of breath
Steven Johnson syndrome particularly in Asians (Screen for HLAB1502 allele before initiation)
A hypertensive crisis occurs when
MAOIs are taken in conjunction with certain medication’s
Common medication include: Meperidine (Demerol), stimulants, decongestants, asthma medication,
Symptoms of hypertensive crisis include
Sudden, explosive like headache, usually in occipital region
 Hypertension, Flushing, palpitations, diaphoresis, fever
Treatment of hypertensive crisis includes
Discontinuing the MAOI
Phentolamine (Blocks by binding to norepinephrine receptor sites)
The treatment for serotonin syndrome
Cryptoheptadine (antihistamine)
Cardinal sign of serotonin syndrome is
Cardinal sign of serotonin syndrome is myoclonic jerking, hyper reflexia, confusion, shivering, goosebumps, tachycardia and hypertension
Teratogenic risks of benzodiazepines
Floppy baby syndrome, cleft palate
Teratogenic risks of carbamazepine
Neural tube defects
Teratogenic Risk of lithium
Ebstein anomaly
Teratogenic risk of Depakote
Spina bifida
For patients taking clozapine and/or carbamazepine (tegretol), Risk for neutropenia is monitored by which lab value
ANC only
DC Clozapine at ANC less than 1000 (Neutropenia) Regardless of whether the patient is showing signs of infection or not
DC clozapine at wbc’s 2000 to 3000 (Agranulocytosis)
For patients taking clozapine, what should the patient be closely monitored for
Signs of infection (Fever, chills, sore throat, weakness)
What is normal BMI
18.5 to 24.9
A BMI less than —— requires hospitalization
<15
Physical exam findings for anorexia
Low BMI
Russells sign (Calluses on dorsum of hand secondary to Induced vomiting)
Brittle hair and nails
Lanugo on face extremities and trunk
Amenorrhea
Emaciation
Bradycardia
Hypotension
BMI for a patient with bulimia nervosa is usually
Normal
As Wellbutrin is know to have more or less sexual side effects
Less sexual side effects because it is an NDRI
Which antidepressant is appropriate for patients experiencing depression with low energy and fatigue
Wellbutrin
Which antidepressant is contraindicated in patients with a history of seizure or anorexia/bulimia
Wellbutrin. Wellbutrin decreases seizure threshold
What are some known cytochrome P450 inhibitors
Pneumonic: SICK FACES.COM
Sodium valproate
Indomethacin
CLARITHROMYCIN/ Cimetidine
Ketoconazole
Fluconazole
alcohol
Chloramphenicol
ERYTHROMYCIN
Sulfonamide
Cipro
Omeprazole
Metronidazole
Grapefruit juice
Wellbutrin