GenPath RC Chap 4

Question 1

What typically causes increase in hydrostatic pressure?

Answer 1

Disorders that impair venous return

e.g. DVT, CHF, constrictive pericarditis, venous obstruction - thrombosis, external pressure

Question 2

What is the central regulator of hemostasis?

Answer 2

Endothelial cells
- the balance between antithrombic and prothrombic activities of endothelium determines whether thrombus formation, propagation, or dissolution occur

Question 3

List materials in alpha and dense granules of platelets

Answer 3

Alpha-granules: P-selectin, fibrinogen, coagulation factor V, vWF, protein factors involved in wound healing (fibronectin, platelet factor 4, PDGF, and TGF-beta)

Dense granules: ADP, ATP, iCa, serotonin, epinephrine