genomic sequencing Flashcards
genome
hereditary info encoded in DNA
genomic sequencing
process where exact sequence of nucleotide bases along gene or entire genome is determined
bioinformatics
comparison of gene sequences from diff organisms using comp and statistical analysis
highly conserved genes
very similar genome sequences to DNA sequences which are positively selected overtime
the more closely related the groups are…
the greater number of conserved DNA sequences they have in common in the genome
phylogenetics
study of evolutionary history and relationships
- compares data from DNA sequences of diff species to determine how diff they are
why is sequence data used
to show evolutionary relatedness of genes between organisms among group of organisms
- to determine main sequence of events in evolution (along w fossil fuels)
molecular clock
show when species diverged during evolution
- assume constant mutation rate and show differences in DNA or AA sequences
what do the differences in sequence data is species indicate
the time of divergence from a common ancestor
pharmacogenetics
use of genome info to advise and assist choice of drugs
- highly imp for improving drug therapy and prescribing
an individuals genome sequence used to…
select most effective drug and dosage to treat their disease