Genome Wide Variation Flashcards
What are snp
Single nucleotide polymorphisms is a variation at a single position in a DNA sequence.
They occur around every 1000 nucleotides meaning there are around 4-5 million in a human genome.
They usually don’t have any effect on health or development but can be used as markers to locate genes and predict responses to drugs/toxins
What is pharmocogenomics and personalised medicine
Study of how individuals genetic makeup influences their response to drugs through whole genome genotyping which allows them to create personalised medicine (medicine tailored made for an individuals genotype)
How genotyping can identify if HIV carriers will have serious side effects to abacavir
They analyse the presence of HLA-B57:01 allele which increases the hypersensitivity to abacavir using microarrays based genotyping
