Genitourinary System

Question 1

Uroselective alpha 1 adrenoreceptor antagonist

Answer 1

Tamsulosin

Question 2

Urological antispasmodic

Answer 2

M cholinoreceptor antagonist - Tolterodine
Beta adrenoreceptor agonist -Mirabegron

Question 3

Phosphodiesterase inhibitor

Answer 3

Sildenafil

Question 4

Overactive bladder

Answer 4

Instability of bladder relaxant muscles or hyperreflexia

Question 5

Symptoms of overactive bladder

Answer 5

Urgency to urinate, frequent urination,nocturia, urinary incontinence

Question 6

OB can be provoked by

Answer 6

stroke,spinal cord injury, multiple sclerosis

Question 7

Erectile dysfunction (ED ) caused by

Answer 7

Diabetic mellitus, vascular disease, medications like BAB, thiazide, spironolactone,benzodiazepine,SSRIs, metoclopramide, anabolic steroids

Question 8

Pontine micturition center (PMC) ensure

Answer 8

That Detruser and sphincter operate synchronously

Question 9

Relaxation of smooth muscle throgh

Answer 9

Beta 2 and 3 receptor

Question 10

Stimulate sphincter through

Answer 10

Alpha 1 adrenoreceptor

Question 11

Parasympathetic stimulation of bladder muscle throgh

Answer 11

M2 and M3

Question 12

External sphincter is controlled throgh

Answer 12

Somatic system

Question 13

Tolterodine (cholinoreceptor antagonist) action

Answer 13

M1 and 3 receptor blockade cause Detruser muscle relaxation, antispasmodic effect

Question 14

Tolterodine use

Answer 14

Overactive bladder and urinary incontinence

Question 15

SE of Tolterodine

Answer 15

Increase Qt interwal,risk of arrythmia, xerostomia

Question 16

Contraindications of Tolterodine

Answer 16

Urinary retention

Question 17

Mirabegron(beta adrenoreceptor agonist) action

Answer 17

Detruser muscle relaxation, reduce afferent activity of bladder,so antispasmodic effect

Question 18

Use of mirabegron

Answer 18

Overactive bladder and urinary incontinence

Question 19

SE of mirabegron

Answer 19

Tachycardia

Question 20

Tamsulosin ( uroselective alpha 1 adrenoreceptor antagonist) action

Answer 20

Decrease urethral tone and relax prostrate muscle,so decrease urinary disturbance

Question 21

Use of Tamsulosin

Answer 21

Symptomatic benign prostate hyperplasia (BPH) therapy

Question 22

SE of Tamsulosin

Answer 22

Overdose cause severe hypotensive reaction

Question 23

Tamsulosin can be used together with

Answer 23

5 alpha reductase inhibitor

Question 24

PDE 5 fn

Answer 24

Degrades cGMP

Question 25

PDE 5 is seen in

Answer 25

Corpus cavernous of penis and in blood vessels of lungs

Question 26

Sildenafil (PDE 5 inhibitor) action

Answer 26

Modulate NO activity, increase conc of cGMP, in both corpus cavernous and pulmonary vascular smooth muscles,smooth muscles relaxation,increase blood flow cause erectile stabilization and cause hypotensive effect in lungs

Question 27

Use of sildenafil

Answer 27

Erectile dysfunction and pulmonary hypertension

Question 28

SE of sildenafil

Answer 28

Headache, hypotension (due to systemic vasodilation)

Question 29

Interactions of sildenafil

Answer 29

No donors