Genitourinary system Flashcards
Bean-shaped paired organs found in the posterior abdominal wall, retroperitoneal
Kidney
What are the functions of the kidneys?
- Urine formation
- Excretion of waste products
- Regulation of electrolytes
- Regulation of acid-base balance
- Control of water balance
- Control of blood pressure
- Renal clearance
- Regulation of red blood cell production
- Synthesis of vitamin D to active form
- Secretion prostaglandins
- Regulates calcium and phosphorus balance
What is the process of renal circulation?
Renal Artery (hilum) branches into afferent arterioles | (Glomerular Capillary beds) | Efferent Arterioles | Renal Vein
Anatomic & functional unit of the kidney where using is formed
Nephron
The three-step process of urine formation in the nephrons
- Filtration – transfer of water and waste from blood to glomerulus
- Reabsorption – water and necessary ions are transferred back into the blood
- Excretion – excess substances and wastes are removed and transferred into urine
What are the parts of nephrons?
- Glomerulus
- Bowman’s capsule
- Proximal Convoluted Tubules (PCT)
- Loop of Henle
- Distal Convoluted Tubules (DCT)
- Collecting Tubules
- It expands as it enters the kidney to form the renal pelvis (subdivided into calyces each containing renal papillae)
- Collects urine secreted by the kidney & propels it to the bladder by peristaltic wave
Ureters
- Hollow, spherical, collapsible bag of smooth muscle
- Behind the symphysis pubis
- Reservoir for urine
- Capacity of the adult bladder 300-500 mL
Urinary Bladder
Musculo-membranous tube lined with mucosa opening to urinary meatus
Urethra
What are the normal urine values?
Color: amber/straw (light yellow) Odor: aromatic Consistency: clear or slightly turbid pH: 4.5-8 Specific gravity: 1.010-1.020 WBC/RBC: (-) Albumin: (-) E coli: (-) Mucus thread: few Amorphous urate: (-)
It is the infection of the urinary bladder that is usually caused by an ascending bacterial infection or E. Coli
Cystitis
Inflammation of the urethra with causative agents: E. Coli, staphylococcus, streptococci, pseudomonas
Urethritis
It is the formation of stones at the urinary tract
Nephrolithiasis or Urolithiasis
What are the types of stones found in the urinary tract?
Acidic and Alkaline stones
It is the slow enlargement of the prostate gland in men > 40 years old
Benigh Prostatic Hyperplasia
It is the infection of the kidney due to bacteria, fungus, and virus
Pyelonephritis
What are the 2 types of pyelonephritis?
• Acute
- Bacterial contamination from urethra by instrumentation (iatrogenic) or hematogenous spread
- E. Coli/streptococcus
• Chronic
- Idiopathic; obstruction or reflex (stone, tumor, or neurogenic bladder)
- Progressive scarring of the kidney resulting in weight loss, hypertension and renal failure
It is the inflammatory & degenerative disorder of the glomerulus. It is also the damage to both kidney from filtration of trapping of antibody-antigen complexes within the glomeruli resulting to decrease glomerular filtration rate
ACUTE GLOMERULONEPHRITIS (AGN)/NEPHRITIC SYNDROME
What are the 2 types of Acute Glomerulonephritis?
• Acute Post-Streptococcal
- After 7 - 10 days after streptococcal throat infection
- Immune reaction to the presence of an infectious organism (group A beta hemolytic streptococcus/GABHS)
• Chronic Glomerulonephritis
- Hypertensive nephrosclerosis
- Heat failure
- Chronic renal failure
Renal pathology characterized by increased glomerular permeability and is manifested by massive proteinuria
Nephrotic Syndrome
Acute tubular necrosis (ATN) renal parenchymal failure, Acute tubule-interstitial Nephritis
Acute Renal Failure
What are the causes of Acute Renal Failure?
• Pre-renal
- Hypoperfusion of kidney
- Volume depletion
- Impaired cardiac efficiency
- Vasodilation
• Intra-renal
- Actual damage to kidney tissue
- Prolonged renal ischemia
- Nephrotoxic agents
- Infectious process
• Post renal
- Obstruction to urine flow
- Urinary tract obstruction
- Calculi (stones), tumors
- Benign prostatic hyperplasia
- Blood clots
What are the four phases of Acute Renal Failure?
- Onset - Benign with initial insult and ends when oliguria develops
- Oliguric Phase - Is accompanied by an increase in the serum concentration of substances usually excreted by the kidney
- Diuretic Phase - marked by a gradual increase in urine output, which signals that glomerular filtration
has started to recover. - Recovery Phase - signals the improvement of renal function and may take 3 to 12 months
It is the irreversible condition of progressive damage to the nephrons & glomerulus and the retention of waste product (uremia)
Chronic Renal Failure
What are the 5 stages of CKF?
Stage 1 - Kidney damage with normal or increased GFR
Stage 2 - Mild increase in GFR
Stage 3 - Moderate increase in GFR
Stage 4 - Severe increase in GFR
Stage 5 - Kidney Failure (ESRD)
What are the 3 stages of CRF?
- Diminished renal reserve volume
- Renal Insufficiency
- End-stage renal disease (ESRD)
Dialyzing solution is introduced via a catheter inserted in the peritoneal cavity
Peritoneal Dialysis
Client is attached (via a surgically created AV fistula or Graft) to a machine that pumps blood along a semi-permeable membrane, dialyzing solution is on the other side of the membrane, and osmosis, diffusion of waste, toxins, and fluid from the client occurs
Hemodialysis
What are the 3 kinds of hemodialysis access?
- AV Fistula - Commonly in the forearm anastomosis artery to vein either side to side or end to end
- AV Graft - Can be created by subcutaneously interposing a biologic, semibiologic, or synthetic graft material between an
artery and vein - Vascular Access Devices - Creation of a double-lumen large core catheter into the subclavian, internal jugular or femoral vein
What are the possible vascular access complications?
- Poor blood flow
- Clotting
- Infection
- Pseudoaneurysm / aneurysm
- Ischemia of the hand
- May contribute to congestive heart failure
Kidney transplantation involves transplanting a kidney from a living donor or deceased donor to a recipient who are longer has renal function
Renal Transplant
Where do organs come from for renal transplant?
- Living related donors
- Living unrelated Donors
- Decreased Donor
- Necessary for chemical reactions and transport
- Contained in the body in several compartments separated by semi-permeable membranes.
Body Fluids
What are the three major compartments?
- Intracellular—the area inside the cell membrane, containing 65 percent of body fluids
- Extracellular—the area in the body that is outside the cell, containing 35 percent of body fluids
- Tissues or interstitial area—contains 25 percent of body fluids
Charged molecules contributes to fluid concentration. Allows fluid movement from one compartment to another.
Electrolytes
What are the major electrolytes in the ICF?
Potassium and Phosphorus
What are the major electrolytes in the ECF?
Sodium and Chloride
What is the normal lab values for Sodium?
135-145 mEq/L
What is the normal lab values for Potassium?
3.5-5.5 mEq/L
What is the normal lab values for Calcium?
4.5-5.5 mEq/L or 8.5-10 mg/dL
What is the normal lab values for Phosphorus?
1.7-2.6 mEq/L
What is the normal lab values for Chloride?
98-108 mEq/L
What is the normal lab values for Magnesium?
1.5-2.5 mEq/L
What are the 3 movements of fluids and electrolytes?
- DIFFUSION — movement of SOLUTE; high to low concentration
- OSMOSIS — movement of SOLVENT; low to high concentration
- HOMEOSTASIS — balance of fluid in the body
What is the normal specific gravity for urine?
1.010-1.020
Indirectly indicates fluid volume in the blood. The test measures the number of blood cells per volume of blood.
Hematocrit
Measures the concentration of particles dissolved in blood.
Serum Osmolality
Measures the concentration of particles dissolved in the urine. The test can show how well the kidneys are able to clear metabolic waste and excess electrolytes and concentrate urine.
Urine Osmolality
It is the major cation INSIDE (ICF) the cell. It is critical to neuromuscular function because it plays an important role in action potentials, nerve
polarization/depolarization and excitability.
Potassium
May be caused by the use of diuretic medications that result in the excretion of potassium in the urine and by the loss of potassium through diarrhea or excessive sweating.
Hypokalemia
Results most commonly from decreased excretion of potassium owing to renal failure. May result from excessive intake or overaggressive treatment of potassium deficit with potassium supplements.
Hyperkalemia
Major cation in the extracellular fluid and spaces. Its concentration across the cellular membrane plays an important part in neuromuscular cell activity.
Sodium
Most often results from excessive fluid retention or infusion that dilutes the sodium in the blood.
Hyponatremia
Results from excessive sodium intake or sodium retention with excessive loss of water owing to diarrhea, diuretic medication use, vomiting, sweating, heavy respiration, or severe burns.
Hypernatremia
Most of the _______ in the body comes from the salt (sodium chloride) ingested and absorbed in the intestines as
food is digested.
Chloride
Any condition that causes a loss of sodium owing to decreased reabsorption of sodium and chloride.
Hypochloremia
Also results from metabolic acidosis owing to the loss of base and respiratory alkalosis that occurs with
hyperventilation.
Hyperchloremia
Mineral necessary for clotting (factor IV). Has a role in cardiac muscle contraction and excitability.
Calcium
Low calcium levels
Hypocalcemia
Most commonly from increased parathyroid function often owing to a tumor or from cancer in the bones that releases
calcium into the bloodstream.
Hypercalcemia
It is found primarily in the intracellular environment and is bound to adenosine triphosphate (ATP). It is important in almost all the body’s metabolic functions.
Magnesium
Excessive urinary loss of magnesium
Hypomagnesemia
Excessive intake of magnesium
Hypermagnesemia
Necessary to maintain acid base balance (through the buffer system)
Phosphate
True or False:
High Phosphate=Low Calcium
Low Phosphate=High Calcium
True
May result from poor absorption such as occurs with ingestion of antacids that bind to phosphate
Hypophosphatemia
Owing to the release of phosphate from the bones by tumors
Hyperphosphatemia
What is the normal ABG value for blood pH?
7.35-7.45
What is the normal ABG value for Partial Pressure Carbon Dioxide (PCO2)?
34-45 mmHg
What is the normal ABG value for Partial Pressure of Oxygen (PO2)?
80-100 mmHg
What is the normal ABG value for Bicarbonate?
22-26
Refers to the decreased blood pH?
Acidosis
Refers to the increased blood pH?
Alkalosis
Refers to the fluid loss without electrolyte loss
Dehydration
Occurs when loss of ECF volume exceeds the intake of fluid ratio of serum electrolytes to water remains the same.
Fluid Volume Deficit (FVD) or hypovolemia
Diagnostic findings for FVD or Hypovolemia
Diagnostic Findings:
• BUN elevated out of proportion to the serum creatinine
• Urine specific gravity is increased
• Decreased urinary sodium and chloride.
• Urine osmolality can be greater than 450 mOsm/kg
Management for FVD/Hypovolemia
Fluid replacement through:
Isotonic electrolyte solutions
- Lactated Ringer’s solution 0.9% sodium chloride
Hypotonic electrolyte solution
- 0.45% sodium chloride
It refers to an isotonic expansion of the ECF caused by the abnormal retention of water and sodium in approximately the same proportions in which they normally exist in the ECF.
Fluid Volume Excess or Hypervolemia
What are the diagnostic findings for Hypervolemia?
Diagnostic Findings:
• BUN and hematocrit are decreased because of plasma dilution
• The urine sodium level is increased if the kidneys are attempting to excrete excess volume.
• Chest x-ray may reveal pulmonary congestion.
What are the managements for hypervolemia?
- Diuretics - to reduce edema
- Potassium supplements - to avoid hypokalemia from the use of diuretics
- Hemodialysis or peritoneal dialysis may be used to remove nitrogenous wastes and control potassium and acid—base balance, and to remove sodium and fluid.
Expected blood gas changes include a low pH (less than 7.35) and a low bicarbonate level (less than 22 mEq/L)
Metabolic Acidosis
Evaluation of arterial blood gases reveals a pH greater than 7.45 and a serum bicarbonate concentration greater than 26 mEq/L.
Metabolic Alkalosis
A clinical disorder in which the pH is LESS than 7.35 and the PaCO2 is GREATER than 45 mm Hg
Respiratory Acidosis
A clinical condition in which the arterial pH is GREATER than 7.45 and the PaCO2 is LESS than 35mmHg.
Respiratory Alkalosis