Genitourinary system Flashcards
Bean-shaped paired organs found in the posterior abdominal wall, retroperitoneal
Kidney
What are the functions of the kidneys?
- Urine formation
- Excretion of waste products
- Regulation of electrolytes
- Regulation of acid-base balance
- Control of water balance
- Control of blood pressure
- Renal clearance
- Regulation of red blood cell production
- Synthesis of vitamin D to active form
- Secretion prostaglandins
- Regulates calcium and phosphorus balance
What is the process of renal circulation?
Renal Artery (hilum) branches into afferent arterioles | (Glomerular Capillary beds) | Efferent Arterioles | Renal Vein
Anatomic & functional unit of the kidney where using is formed
Nephron
The three-step process of urine formation in the nephrons
- Filtration – transfer of water and waste from blood to glomerulus
- Reabsorption – water and necessary ions are transferred back into the blood
- Excretion – excess substances and wastes are removed and transferred into urine
What are the parts of nephrons?
- Glomerulus
- Bowman’s capsule
- Proximal Convoluted Tubules (PCT)
- Loop of Henle
- Distal Convoluted Tubules (DCT)
- Collecting Tubules
- It expands as it enters the kidney to form the renal pelvis (subdivided into calyces each containing renal papillae)
- Collects urine secreted by the kidney & propels it to the bladder by peristaltic wave
Ureters
- Hollow, spherical, collapsible bag of smooth muscle
- Behind the symphysis pubis
- Reservoir for urine
- Capacity of the adult bladder 300-500 mL
Urinary Bladder
Musculo-membranous tube lined with mucosa opening to urinary meatus
Urethra
What are the normal urine values?
Color: amber/straw (light yellow) Odor: aromatic Consistency: clear or slightly turbid pH: 4.5-8 Specific gravity: 1.010-1.020 WBC/RBC: (-) Albumin: (-) E coli: (-) Mucus thread: few Amorphous urate: (-)
It is the infection of the urinary bladder that is usually caused by an ascending bacterial infection or E. Coli
Cystitis
Inflammation of the urethra with causative agents: E. Coli, staphylococcus, streptococci, pseudomonas
Urethritis
It is the formation of stones at the urinary tract
Nephrolithiasis or Urolithiasis
What are the types of stones found in the urinary tract?
Acidic and Alkaline stones
It is the slow enlargement of the prostate gland in men > 40 years old
Benigh Prostatic Hyperplasia
It is the infection of the kidney due to bacteria, fungus, and virus
Pyelonephritis
What are the 2 types of pyelonephritis?
• Acute
- Bacterial contamination from urethra by instrumentation (iatrogenic) or hematogenous spread
- E. Coli/streptococcus
• Chronic
- Idiopathic; obstruction or reflex (stone, tumor, or neurogenic bladder)
- Progressive scarring of the kidney resulting in weight loss, hypertension and renal failure
It is the inflammatory & degenerative disorder of the glomerulus. It is also the damage to both kidney from filtration of trapping of antibody-antigen complexes within the glomeruli resulting to decrease glomerular filtration rate
ACUTE GLOMERULONEPHRITIS (AGN)/NEPHRITIC SYNDROME
What are the 2 types of Acute Glomerulonephritis?
• Acute Post-Streptococcal
- After 7 - 10 days after streptococcal throat infection
- Immune reaction to the presence of an infectious organism (group A beta hemolytic streptococcus/GABHS)
• Chronic Glomerulonephritis
- Hypertensive nephrosclerosis
- Heat failure
- Chronic renal failure
Renal pathology characterized by increased glomerular permeability and is manifested by massive proteinuria
Nephrotic Syndrome
Acute tubular necrosis (ATN) renal parenchymal failure, Acute tubule-interstitial Nephritis
Acute Renal Failure
What are the causes of Acute Renal Failure?
• Pre-renal
- Hypoperfusion of kidney
- Volume depletion
- Impaired cardiac efficiency
- Vasodilation
• Intra-renal
- Actual damage to kidney tissue
- Prolonged renal ischemia
- Nephrotoxic agents
- Infectious process
• Post renal
- Obstruction to urine flow
- Urinary tract obstruction
- Calculi (stones), tumors
- Benign prostatic hyperplasia
- Blood clots
What are the four phases of Acute Renal Failure?
- Onset - Benign with initial insult and ends when oliguria develops
- Oliguric Phase - Is accompanied by an increase in the serum concentration of substances usually excreted by the kidney
- Diuretic Phase - marked by a gradual increase in urine output, which signals that glomerular filtration
has started to recover. - Recovery Phase - signals the improvement of renal function and may take 3 to 12 months
It is the irreversible condition of progressive damage to the nephrons & glomerulus and the retention of waste product (uremia)
Chronic Renal Failure
What are the 5 stages of CKF?
Stage 1 - Kidney damage with normal or increased GFR
Stage 2 - Mild increase in GFR
Stage 3 - Moderate increase in GFR
Stage 4 - Severe increase in GFR
Stage 5 - Kidney Failure (ESRD)
What are the 3 stages of CRF?
- Diminished renal reserve volume
- Renal Insufficiency
- End-stage renal disease (ESRD)
Dialyzing solution is introduced via a catheter inserted in the peritoneal cavity
Peritoneal Dialysis
Client is attached (via a surgically created AV fistula or Graft) to a machine that pumps blood along a semi-permeable membrane, dialyzing solution is on the other side of the membrane, and osmosis, diffusion of waste, toxins, and fluid from the client occurs
Hemodialysis
What are the 3 kinds of hemodialysis access?
- AV Fistula - Commonly in the forearm anastomosis artery to vein either side to side or end to end
- AV Graft - Can be created by subcutaneously interposing a biologic, semibiologic, or synthetic graft material between an
artery and vein - Vascular Access Devices - Creation of a double-lumen large core catheter into the subclavian, internal jugular or femoral vein
What are the possible vascular access complications?
- Poor blood flow
- Clotting
- Infection
- Pseudoaneurysm / aneurysm
- Ischemia of the hand
- May contribute to congestive heart failure
Kidney transplantation involves transplanting a kidney from a living donor or deceased donor to a recipient who are longer has renal function
Renal Transplant
Where do organs come from for renal transplant?
- Living related donors
- Living unrelated Donors
- Decreased Donor
- Necessary for chemical reactions and transport
- Contained in the body in several compartments separated by semi-permeable membranes.
Body Fluids