Genitourinary Medicine Flashcards
Which bacteria are essential to controlling the vaginal pH?
Lactobacilli
What is the pathophysiology of bacterial vaginosis?
Reduced lactobacilli = reduced lactic acid = increased pH = anaerobic bacteria multiply e.g. G vaginalis / M hominids/ Prevotella sp.
Give the risk factors for bacterial vaginosis.
Multiple sexual partners Excessive vaginal cleaning Recent ABX Smoking Copper coil
What are the clinical features of bacterial vaginosis?
Asymptomatic
Vaginal odour: fishy (due to amines)
White/grey vaginal discharge
Clue cells are pathognomonic of?
Bacterial vaginosis
Which criteria can be used to make a diagnosis of Bacterial Vaginosis?
Amsel Criteria (3/4): pH > 4.5 White/grey discharge Fishy odour Clue cells
What is the management for Bacterial vaginosis?
Metronidazole PO 400mg BDS 5-7 days
Can use throughout pregnancy
What is the most common cause of Bacterial vaginosis?
Gardnerella vaginalis
What is the gold standard investigation in Bacterial vaginosis?
Vaginal swab and microscopy + gram-stain
What pathogen is the cause for vaginal candidiasis?
C albicans
How may genital thrush be classified?
Uncomplicated: simple, single cause and no other comorbidities
Complicated: recurrent (≥4 episodes); severe infection; major co-morbidity
Give 3 RFs for Vulvovaginal candidiasis
Poorly controlled diabetes
Immunocompromised
Local irritants
Broad-spectrum ABX
Sexual activity
HRT
What are the clinical features of vulvovaginal candidiasis?
Non-malodorous, thick and white vaginal discharge
Vaginal itching
Vaginal soreness
Vulvovaginal irritation
Vaginal fissuring
Excoriation
How is VV Candidiasis managed?
Uncomplicated
Intra-vaginal Clotrimazole 10% single dose
Complicated
Fluconazole PO 150mg BDS for 2/7 (3 days apart)
If a patient has VV Candidiasis refractory to treatment within 7-14 days, what is your next steps?
Confirm Tx course and adherence \+ Reassess RF \+ Consider alternative diagnosis \+ Consider treatment
A patient is on their 4th episode of thrush this year. How would you manage them?
Supportive: RF modification
+
Medical: Oral Fluconazole 14/7 (induction) + Oral Fluconazole for 6/12 (maintenance)
Which pathogen causes Trichomonas?
Trichomonas vaginalis - a protozoa
What are the clinical features of Trichomonas?
Malodorous, frothy green-yellow discharge
Vulval itchiness
Inflammation of the vulva/glans
What investigations should be conducted in a patient with potential Trichomonas infection?
Cervical inspection
Vaginal swab
Microscopy
NAAT
Culture
What is the management for Trichomonas?
Metronidazole PO 400mg BDS for 5/7
what pathogen causes Chlamydia?
Chlamydia trachomatis
What is the gold-standard test for Chlamydia?
NAAT
VVS (F)
FCU (M)
Which serovars of Chlamydia cause Trachoma?
A-C
Which serovars of Chlamydia cause LGV?
L1-L3
Which serovars of Chlamydia cause Urogenital infection?
D-K
What are the clinical features of Chlamydia?
Majority (75% F cf 50% M) are asymptomatic
If symptoms: Vaginal/ Urethral discharge Post-coital bleeding Intermenstrual bleeding Dysuria Lower abdominal pain Deep dyspareunia
What are the complications of Chlamydia?
Tubo-ovarian abscess
Fitz-Hugh-Curtis Syndrome
Infertility
Ectopic pregnancy
Chronic pelvic pain
What are the clinical features of Fitz-Hugh-Curtis Syndrome?
Complication of PID due to Chlamydia/Gonorrhoeal infection featuring RUQ due to pelvic adhesions
What is the management of Chlamydia?
Doxycycline 200mg STAT then 100mg PO OD 7/7
+
Ceftriaxone IM 1g STAT
+
Test of cure 4 weeks later
Which conditions cause genital ulcers?
Syphilis HSV HPV Granuloma inguinale LGV Chancroid
Which patient group is Lymphgranuloma venereum more prevalent amongst?
MSM
What are the 3 stages of infection of LGV?
Primary: Painless papule/pustule or ulcer
Secondary: Regional lymphadenopathy (femoral/inguinal) days to weeks after primary lesion with lymphadenitis become confluent to form a buboe
Tertiary: Recover OR chronic anogenital infection which causes proctocolitis, fistulae, strictures or fibrotic areas
What are the clinical features of LGV?
Two areas affected - the genitals + the anus
Painless pustule/papule/ulcer
Rectal pain
Rectal bleeding
Rectal discharge
Tenesmus
Lymphadenopathy Lymphadenitis Buboes Groove sign (inguinal and femoral lymphadenopathy separated by inguinal ligament) Systemic upset
Proctitis
Fistulae
Strictures
What conditions is Groove sign seen in and how is it caused?
LGV due to lymphadenopathy of femoral and inguinal regions which is separated by the inguinal ligament
How is LGV diagnosed?
Swab + NAAT
How is LGV managed?
Supportive: Avoid sexual contact + trace testing (4 weeks of symptoms or 3 months of asymptomatic carriage)
+
Medical: Doxycycline 100mg PO 3/52
What are the complications of LGV?
Lymphoedema
Fistulae formation
Strictures
Disfiguring fibrotic scarring
Which organism causes Gonorrhoea?
Neisseria gonorrhoea
What is the morphology of N gonorrhoea?
Gram negative diplococci
What proportion of gonorrhoea infections cause disseminated infection?
1%
What are the complications of Gonorrhoea?
Septic arthritis Meningitis Reiter's Syndrome Conjunctivitis Endocarditis
PID Tubal infertility Ectopic pregnancy Chronic pelvic pain Fitz-Hugh-Curtis Syndrome
Prostatitis
Epididymo-orchitis
PID
What are the clinical features of Gonorrhoea infection?
Urethral discharge (M > F) - mucopurulent discharge
Cervicitis - and vaginal discharge
Lower abdominal pain
Dysuria
Testicular pain
What is the gold-standard test for Gonorrhoea?
NAAT - urethral swabs (M) and VVS (F)
What is the management of Gonorrhoea?
Supportive: Contact tracing 3/12; Stop sexual contact until 7 days post-treatment; Test of cure 1/12
+
Medical: Ceftriaxone IM 1g
Which pathogen causes Syphilis?
T pallidum
What are the clinical features of Syphilis?
Primary features:
- Chancre (painless ulcer)
- Local, non-tender lymphadenopathy
Secondary features:
- Fever
- Lymphadenopathy
- Rash on trunk and volar surfaces
- Buccal snail track ulcers
- Condylomata lata (painless, warty lesions on genitalia)
Tertiary features:
- Gummas (granulomatous lesions of skin and bone)
- Ascending aortic aneurysms
- Tabes dorsalis
- Argyll-Robertson pupil
What are the clinical features of congenital syphilis?
Deafness
Saddle nose
Rhagades (linear scars at angle of mouth)
Keratitis
Blunted upper incisor teeth (Hutchinson’s teeth)
Mulberry molars
Clutton’s joints (symmetrical joint swelling - e.g. knees)
Saber shins (tibial bowing from chronic inflammation)
What is Latent Syphilis?
An asymptomatic period in which there is serological evidence of infection but no symptoms
1) Early latent syphilis = <2 years from infection
2) Late latent syphilis =>2 years from infection
In which condition is an Argyll-Robertson pupil seen?
Outline what is seen.
Neurosyphilis - constricted pupil accommodates when focusing to nearby object but does not react to light
How is Syphilis diagnosed?
Ab test - Serology
How is Syphilis managed?
IM Benzathine benzylpenicillin
What is a Jarisch-Herxheimer reaction?
Acute febrile illness presenting in first 24 hours of Syphilis treatment with headache, myalgia, chills and rigors.
Reaction occurs following initial dose of anti-treponemal treatment.
Occurs in 10-35% patients.
How do you manage a Jarisch-Herxheimer reaction?
NSAIDs
+
Prednisolone PO 40-60mg 3/7 (after first dose of anti-treponemal ABx)
Which bacterium causes Granuloma inguinale?
Klebsiella granulomatis
What are the clinical features of Granuloma inguinale?
Painless papule/nodule with beefy red appearance (high vascularity) in the genital or inguinal region
Papule/Nodule develop an ulcerated appearance - ulcerate from the middle with friable, raised and rolled margin
How is Granuloma inguinale diagnosed?
Clinically, due to lack of resources in endemic regions
PCR with Donovan bodies seen
How is Granuloma inguinale managed?
Azithromycin 1g PO weekly
What are the complications of Granuloma Inguinale?
Malignant change - e.g. Squamous Cell Carcinoma Lymphoedema Haematogenous spread Polyarthritis Osteomyelitis Stenosis (anus/vagina) Mental Health Disease
Which pathogen causes Chancroid?
Haemophilus ducreyi