Genital development Flashcards
What are genital ridges
Ridges of mesenchyme and epithelium
At what week do primordial germ cells (PGC) migrate to the genital ridge
week 6
If primordial genital cells (PGC’s) do not make it to the genital ridges what will happen
gonads will not develop
In males what do the primitive sex cords form
testis cords
What are the testis cords composed of
sertoli cells
Germ cells
what cells are between the testis cords and what to get produce
Leydig
Testosteron
In males the primitive sex cords
a) develop
b) regress
a
In females, primitive sex cords
a)develop
b)regress
b
In females which cords develop
cortical
Germ cell + surrounding cells =
primordial follicle
at what point in development is sex determines
fertilisation
T/F the gonad is undifferentiated at fertilisation until week 7
True
In the undifferentiated gonad what are the 2 pairs of ducts
mesonphric (mullerian)
paramesonphric (wolfian)
At what point do the gonads begin to differentiate
week 7
What occurs in male gonadal differentiation
SRY gene = development of the testes
anti mullerian hormone causes paramesonephric (mullerian) ducts regress
what occurs in female gonadal differentiation
absence of SRY gene
WNT4 required for ovarian development
Oestrogen causes differentiation and paramesonephric (wolfian) ducts develop
Describe the paramesonephric (mullerian) genital duct
-it opens into the abdominal cavity at the rostral end
-caudal ends meet in the midline
-projects into the urogenital sinuses
Describe the mesonephric (wolffian) genital duct and what influence they develop under
-testosterone
-form the vas defers
-distal end opens into the urogenital sinus and. absorbed into the bladder so ureter and duct enter separately
where do the seminal vesicles develop from
vas deferents
which cells produce anti mullerian hormone
Sertoli cells
what does production of anti mullerian hormone cause
regression of paramesonephric ducts
what parts of the Paramesonephric ducts form the uterus, cervix and upper vagina
caudal parts
what is a septet uterus
uterine septum doesn’t regress
What is a unicornuate uterus
one of paramesonephric ducts doesn’t develop
