Genetics of inflammatory disease

Question 1

Features of psoriasis

Answer 1

itchiness, cracked skin, pain, pitted nails, arthritis, social isolation

Question 2

Triggers of psoriasis

Answer 2

infections, skin traumaa, psychological stress, drugs, sunburn, metabolic factors, hormonal factors, unknown skin antigens stimulate immune response leads to impaired differentiation and hyperproliferation of keratinocytes

Question 3

what are the differences between the 2 types of IBD

Answer 3

Ulcerative colitis: inflammation/ulcers only in the mucosa of colon
crohn’s disease: inflammation of all layers of the GI tract

Question 4

What are the different features of IBD

Answer 4

ulcerative colitis-continuous inflammation, colon only, superficial inflammation, variable extent, risk of cancer, extra-intestinal manifestations
crohn’s disease-patchy inflammation, mouuth to anus involvement, full thickness inflammation, fistulas and strictures, risk of cancer, extra-intestinal manifestations

Question 5

Hypotheses of causes of IBD

Answer 5

persistent infection, dysbiosis (decrease protective bacteria, increase aggressive commensals), dysregulated immune response, defective mucosal integrity

Question 6

Symptoms of Systemic lupus erythematosus

Answer 6

discoid lupus, joint disease, collapsing femur, vasculitis, kidney failure, butterfly rash

Question 7

SLE aetiology

Answer 7

Unknown, chronic inflammatory multi system disease

skin, joint, kidneys, CNS involvement

Question 8

what happens in SLE

Answer 8

auto antibody production: nuclear antigens, cellular antigens, cell surface antigens, serum components

Question 9

Compare the ethnic bias, age of onset, aetiology, risk factors for: SLE, Crohn’s disease, ulcerative colitis

Answer 9

ref. notes

Question 10

Draw a flow chart of what happens after GWAS

Answer 10

ref. notes