Genetics of Complex Obesity Flashcards
1
Q
What diseases are linked with obesity?
A
- Type 2 Diabetes
- Cardiovascular disease
- Hypertension
- Cancer
2
Q
Genome Wide Association Studies (GWAS)
A
- Large populations of people
- Disease status and or trait information
- Single nucleotide polymorphism (SNP) DNA genotypes at very high density - tend to be common variants
- Statistical analysis tools
3
Q
What is the FTO Locus
A
Region in 1st intron of FTO Gene on Chromosome 16, strongly associated with BMI and obesity in GWAS studies
4
Q
A