Genetics Chapter 1 & 2 Flashcards
Genetics
Study of inheritance - How things were inherited
Phenotypes
Observed Traits
Molecular TRANSMISSION of Hereditary Material
(DNA,GENOTYPE)
Molecular EXPRESSION of Hereditary Material
(RNA, Proteins)
Locus / Loci
Chunk of DNA with function
Gene
A stretch of DNA that encodes
What is DNA
DNA is a linear polymer (repeated units) of nucleotides.
A nucleotide is composed of
- Phosphate Group
- Deoxyribose Sugar (5 Carbon Sugar)
- Nitrogenous Space ( Adenine, Cytosine, Guanine, Thymine)
Describe DNA structure
DNA strands are ANTI parallel (Double helix)
Two paired DNA strands are complimentary
Reverse complements - A,T & C,G
DNA strands have polarity: 5’ and 3’ ends
Outside is very water soluble, inside is water repellent - Nitrogen bases are inward, and sugar phosphate is outward
Genetic information is stored in the sequence of nucleotide in DNA
DNA is contained in chromosomes (which also has a protein)
What is a genome ?
Total DNA of an organism
- Genes are coded information for building proteins or building RNA
DNA Splicing
When DNA is transcribed into RNA it needs to remove introns
Introns get cut out bc they intervene
Introns are way larger than exons
Exons are left because they are protein-coding regions
When the protein regions are being created that called translation
Central Dogma of Molecular Biology
- DNA transcribed into mRNA, Translated into protein
- mRNA is a compliment of DNA but protein is a diff language
What is the RNA start Codon ?
AUG (it can never be right at the start)
What are the parts of a protein
- Amino Group
- Side chain 1 (can change AND UNQIUE to every amino acid)
- Carboxyl Group (COOH)
Describe RNA strands
- Single strands that are complementary to DNA strand
Who first sequenced peptides / proteons
Frederick Sanger (Insulin, 1955)
When was the first gene sequences
1972