Genetics 4 Flashcards
1
Q
Concordant
A
same disease seem in family
2
Q
Discordant
A
disease not seen in reletive, despite shared genotype (may lack needed exposure)
3
Q
Lambda (R)
A
Disease prevalance in first degree reletaive / General population
4
Q
If lambda R = 1 ,then
A
no gene contribution
5
Q
Threshold model
A
certain genes cause partial risk (smoking)
6
Q
Carter Effect
A
different thresholds in male and females
7
Q
Empiracle considerations for Multifactorial disorders
A
- Rule out chromosome abnormaltiy
- Actual is different than average
- May differ with gender
8
Q
Thrifty gene hypothesis
A
Evidence of hereditary epigenetic modification
