Genetic Recombination And Linkage Analysis

Question 1

Locus

Answer 1

The position that a gene occupies in a chromosome or within a segment of genomic DNA

Question 2

What is the molecular basis for the law of independent assortment

Answer 2

Genes act separately fro one another during meiosis

Question 3

Parental Gametes

Answer 3

Gametes produced by an individual that have the same genotype at the loci of interest as the individuals that produced it

Question 4

Recombinant Gamete

Answer 4

Those gametes produced by an individual that have a different genotype at the loci of interest from the gametes that formed them

Question 5

Synteinic genes

Answer 5

Genes on the same chromosome

Question 6

What preserves the law of independent assortment for syntenic genes or genes on the same chromosome

Answer 6

Crossing over

Question 7

Complete Linkage (Tight)

Answer 7

Genes that are close together on the same chromosomes pass through meiosis together and no recombinant genomes are observed

Question 8

Linkage disequilibrium

Answer 8

The non random distribution into the gametes of a population of the alleles of the genes that reside on the same chromosome

Question 9

Partial Linkage

Answer 9

Recombination is observed, but recombinant types are less than the total parental types

Question 10

Partial Linkage

Answer 10

% of recombination serves as measure between the two genes in question

Question 11

How do you calculate the number of recombinants

Answer 11

Determine the phase of the alleles in question and the number of recombinant gametes produced by and individual or population of a known genotype

Question 12

Haplotype

Answer 12

The symbolic representation of a specific combination of linked alleles on a particular chromosome

Question 13

What is coupling

Answer 13

When the alleles of two genes are on the same chromosome

Question 14

What is repulsion

Answer 14

The alleles of two genes are on different chromosomes

Question 15

Why is there limited crossing over in X and Y chromosomes

Answer 15

Limited sequence homology

Question 16

What causes partially linked genes to have more recombination events

Answer 16

Further distance away from each other

Question 17

%recombination=

Answer 17

(#recombinants/total # progeny)*100

Question 18

1% recombination is what

Answer 18

1cM

Question 19

1cM is how many kb

Answer 19

700

Question 20

If the percent recombination is 40, what is the parental and recombinant breakdown

Answer 20

Parental= 30M and 30D (60 total)

Recombinant 20M and 20D (40 total)

Question 21

If percent recombination is 20 then what is the parental and recombinant contribution

Answer 21

Parental so is 40 apiece (80)and recombinants are 10 apiece (20)

Question 22

When are map distances actually valid

Answer 22

Intervals where there is only one crossover event likely to occur

Question 23

Doe crossing over occur more between autosomal in male meiosis or female meiosis

Answer 23

Female meiosis

This means the female genetic map is larger than the male even though the physical length is the same

Question 24

Why does crossing over no occur at the same frequency throughout the genome

Answer 24

Hot and cold spots

Question 25

Where is crossing over more frequent in the genome relative to other regions

Answer 25

Telometric portions