Genetic Processes Flashcards

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1
Q

What is genetics (definition)

A

study of genes, heredity, and variation of organisms

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2
Q

Major Fields of Genetics (3)

A

Transmission genetics
Molecular genetics
Population genetics

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3
Q

Epigenetics

A

New genetic field

Epigenetics = turning genes on/off
E.g. what women eat affects eggs → eating habits, lifestyle

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4
Q

Jobs involved in genetics

A

Medical research scientist
Scientific laboratory technician
Genetic counselor

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5
Q

Trait (definition)

A

characteristic of an organism

traits can be inherited or acquired

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6
Q

Inherited traits

A

Traits from our ancestors

E.g. 1 eye colour from mom, 1 eye colour from dad
Inherited traits come from chromosomes → found inside nucleolus

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7
Q

Acquired traits

A

traits from environmental change

E.g. dyeing hair (sunbleached), gaining weight, freckles from sun

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8
Q

What is DNA?

A

deoxyribo nucleic acid

DNA is organized into genes

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9
Q

What are genes

A

Distinct part of a cell’s DNA, which are coded instructions for making everything the body needs, especially protein

Carry distinct code for specific inherited traits

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10
Q

Alleles

A

allele: variations of the same gene found on the same place of the chromosome

  • We all carry the same types of genes, but the alleles we carry and are expressed accounts for variation
  • The dominant version of the allele is expressed, the recessive alleles are not expressed, but can be passed down to the next generation
  • i.e. everyone has genes that determine eye colour, but not everyone has the same versions of those genes (alleles), which means that not everyone has the same eye colour
  • e.g. someone with a brown eye (dominant) and blue eye (recessive) allele combination will have brown eyes - Their children could have blue eyes if they have two blue eyed alleles
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11
Q

Eukaryote vs Prokaryote

A

Eukaryotes have a membrane-bound nucleus
* Prokaryote = before nucleus
* Eukaryote = full nucleus

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12
Q

Chromatin

A

Combination (DNA + protein), very thin, not visible under light microscope

  • Resembles big bowl of spaghetti
  • DNA in chromatin tightly coiled around histones (proteins)
  • DNA in histones package structures called nucleosomes (looks like beads)
  • Coils up to form chromosomes
  • Coiling prevents damage
  • Chromatin coils when leaves nucleus
  • Outside of chromosome is not coding
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13
Q

Chromosomes

Definition + how many total

A

One long condensed DNA molecule with hundreds of thousands of genes inside
* Coiled up version of chromatin
* 46 total = 23 from each parent
* Human body cell has enough DNA to stretch 2m long

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14
Q

Watson and Crick

What did they invent + its basic structure

A

Invented double helix model of DNA
* Sugar-phosphate backbone (outside of 2 helix subunits)
* Nitrogenous bases (on inside) = where genetic information is stored, coding occurs here

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15
Q

DNA Structure

A

DNA molecule consists of two polynucleotide chains, which form a double helix structure
* Molecules of DNA made up of long chain of tiny subunits called nucleotides, which form a polynucleotide chain

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16
Q

Nucleotides made up of

A

Backbone:
* Phosphate group
* Deoxiribose = ring-shaped sugar (pentose sugar)
Base:
* Nitrogen base (nitrogeneous group) = single or double ring, carbon + nitrogen atoms

17
Q

Types of Nucelotides

A

4 types of nucleotides that differ only by their nitrogen base
1. Adenine
2. Guanine
3. Thymine
4. Cytosine

18
Q

Pyrimidines

A

single ring structures → T and C

19
Q

Purines

A

double ring structures → A and G

20
Q

Sugar-Phosphate Backbone (how do nucleotides join)

A

Nucleotides can join via covalent bond
* = links sugar of one nucleotide to phosphate group of next
* Tight bond formed between purine and pyrimidine, giving DNA spiral shape

21
Q

Complementary Base Pairing

A

Purines and pyrimidines bind together:
* A + T (apples go on the tree)
* C + G (car goes in the garage)
Along each strand of the double helix, each base goes w its complementary base
* If we know one polynucleotide strand, we can determine the other
* Different combination of base pairs can code for different proteins, genes, and functions

22
Q

Codons

A

bases are arranged in triplets → to crack genetic code we need to look at the sequence of bases

23
Q

Gene (definition + sequence of bases)

A

section of DNA that codes for protein
* Each gene has a unique sequence of bases
* Unique sequence of bases will code for the production of unique protein → give us unique phenotypes

24
Q

The Cell Cycle (overview)

A

Every eukaryotic cell goes through the cell cycle

Composed of 2 main Stages:
* Interphase (G1, S, G2)
* Cell division stage = M phase (mitotic) = making of a new cell

25
Q

Cell Cycle Diagram

A

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26
Q

Interphase

A

Carries out metabolic processes, performs regular cellular activities
* may spend 90% of life cycle in interphase

Cell prepares for division by:
* increasing protein supply
* creating more cytoplasmic organelles
* growing in size
* DNA is duplicated (S phase - synthesis)
* If DNA doesn’t duplicate before mitosis, it will just split up

27
Q

M Phase (mitotic phase)

A

Stage of cell cycle where cell division occurs

Contains 2 processes:
* Mitosis
* Cytokinesis

28
Q

Order of M phase stages

A

PMAT = prophase, metaphase, anaphase, telophase

29
Q

Mitosis

A

During mitosis, nucleus and duplicated chromosomes divide and are equally distributed between two daughter nuclei

30
Q

Cytokinesis

A

cytoplasm divides into to
* begins before mitosis is complete

31
Q

Preparing and Dividing the DNA

A
  • DNA replication → before the cell divides, there must be two copies of DNA
  • Chromatin fibers condense into chromatids (half of chromosome) and ready for division
  • Each chromosome now consists of two identical joined copies of sister chromatids
  • Sister chromatids joined together by centromere
32
Q

Chromosomes (Number)

A
  • Each human cell starts with 46 chromosomes, each made w 2 sister chromatids
  • When cell divides the 92 chromatids separate from each other
  • When separated each sister is condensed into a full fledge chromosome
  • Result is 2 nuclei each containing 46 individual chromosomes
33
Q

Telomeres

A

protective caps of chromosomes not containing info for making proteins

34
Q

Importance of Telomeres

A
  • Everytime eukaryotic cell divides the ends of each chromosomes loses a small amount of DNA
  • Once telomeres have gotten too short, the cell can no longer divide
  • Chromatin in nuclear pore wraps itself when getting ready for mitosis
35
Q

Female and Male Chromosomes

A

Female = XX
Male = XY
* Females will always give X chromosome to their child
* Males can give X or Y chromosome to their child → males are the ones who determine the sex of the baby