Genetic & Pediatric Diseases

Question 1

1. A pathologist is performing an autopsy on an
   individual who died as the result of a motor vehicle
   accident. During the external examination, the
   pathologist notes that there are about 20 brown
   macules on the skin with multiple soft dermal nodules
   of the same color as the skin. A biopsy of the
   nodules would reveal?
   A. Malignant melanocytes
   B. Schwann cells and fibroblasts
   C. Entrapped sebaceous fluid
   D. Pus
   E. Adipose cells and macrophages

Answer 1

1. Correct: Schwann cells and fibroblasts (B)
   This patient has the characteristic features of neurofibromatosis
   type I: neurofibromas and café-au-lait
   spots. The neurofibromas are benign tumors composed
   of Schwann cells, fibroblasts, and collagen (B).
   For (A, C-E), see explanation.