Genes And Neurons Flashcards
Nestadt year
2010
Nestadt 2010
68% MZ had OCD
31% DZ had OCD
Cromer year
2007
Cromer 2007
Over half of OCD patients had a previous traumatic event in their past
Those with more severe cases had more trauma experiences
Diathesis- stress model
Genes cause vulnerability but OCD is triggered by an environmental stressor
Gene explanation
OCD is caused by candidate genes
Polygenic condition
Sert gene transports serotonin
Neural explanation
Abnormal levels of neurotransmitters
Regions in the brain
Serotonin
Mood levels
Orbitofrontal cortex
Converts sensory info into thoughts and actions
Increase in activity in
Orbitofrontal cortex
Increase conversion of sensory info to thoughts and actions
Increases compulsions
Supporting evidence
Use of antidepressants to treat OCD and depression
Works solely to increase levels of serotonin
Weakness
Evidence of disruption of neurotransmitters in patients
But could be a result of OCD rather than cause?