Generic/Brand Flashcards
Amaryl
Glimepiride
Glucotrol
Glipizide
DiaBeta
Glyburide micronase
Glynase
Glyburide micronized
Avandia
- FDA removed restriction on
- BBW
Rosiglitazone
- FDA recently removed restriction below
- Avandia-Rosiglitazone Medicines Access Program: will only be available thr a special mail-order. MDs and pts are enrolled. Special pharmacies are part of the program, and will be the only pharmacies that can mail the drugs
- BBW: possible HF
- can lead to ischemic HF
Actos
Pioglitazone
Precose
- Administration
Acarbose
- Give with 1st bite of meal
Starlix
- Direction for administration
Nateglinide
- Give 30 min b/4 meals
- Skip meal/skip dose & add meal/add dose
Cycloset
- Indication
Bromocriptine
- Indication: DM
Afrezza
- CI:
- SEs
- Storage
- Exp at RT:
- Exp of opened strips:
- Cartridge:
RA insulin human inhalation powder
- CI: any lung disease => lung cancer, asthma
- SEs: HypoG, cough/bronchospasm, hypoK, fluid retention/HF
- Storage: fridge
- Exp at RT: 10 days
- Exp of opened strips: 3 days
- Cartridge: leave at RT x 10min before use
Humalog
- Class
Lispro
- RA insulin
Novolog
- Class
Aspart
- RA insulin
Apidra
- Class
Glulisine
- RA insulin can give IV in hospital w/ monitoring
Short Acting Insulin:
- Drugs in this class
- Appearance:
- Expiration at RT
Regular insulin (OTC)
- Humulin R => RT 31 days
- Novolin R => RT 42 days
- Appearance: clear
Intermediate Acting Insulin:
- Drugs in this class
- Appearance:
- Expiration at RT
NPH (cloudy) (OTC)
- Humulin N => RT Exp 31 days
- Novolin N => RT Exp 42 days
Detemir
- Frequency
- Exp date at RT:
Levemir
- Give BID
- Exp in 42 days
Lantus
- Frequency
- Mixing direction
- Exp date at RT:
Glargine
- Give QD
- NEVER mix w/ other insulins => pH is 4
- Exp: 28 days
Symlin
- Indication
- Do not give
- Dose
Type I and Type II - MOA
- SEs
- Storage
- Exp:
Pramlintide - Pen
- Indication: postprandial glycemic control
- Do not give to: hypersensitivity to metacresol preservative, gastroparesis or on GI motility med, on alpha glycosides inhibitors
- Dose
Type I: 15 mcg
Type II: 60 mcg - MOA: increase AMYLIN = delay gastric emptying, inhibits postprandial glucose release, reduce appetite
- SEs: HypoG, anorexia, wt loss, nausea
- Storage: fridge
- Exp: 30 days at RT
Diabinese
- Class
Chlorpropamide
- Class: 1st generation of Sulfonylureas
Tolinase
- Class
Tolazemide
- Class: 1st generation of Sulfonylureas
Orinase
- Class
Tolbutamide
- Class: 1st generation of Sulfonylureas
Glucophage
Glucophage XR
Metformin
- Max dose:
Glucophage 2550mg/d
Glucophage XR: 2000mg/d
Glucovance (R)
Glyburide/Metformin
Avandamet (R)
Rosiglitazone/Metformin
- Avandia = Rosiglitazone
Trajenta
Jentadueto
Linagliptin
Linagliptin/Metformin
Actoplus Met
Pioglitazone/Metformin
Actos = pioglitazone
Prandin
Prandimet
Repaglinide
Repaglinide/Metformin
Onglyza
Kombiglyze XR
- Max dose
Saxagliptin
Saxagliptin/metformin ER
-Max dose: Max 5mg sax & 2000 mg ER metformin
Avandia === Amaryl === Avandaryl
Rosiglitazone === Glimepiride ==== Rosiglitazone and Glimepiride
Prandin
- Administration direction
Repaglinide
- Give 15 min b/4 meal
- Skip meal/skip dose & add meal/add dose
Glyset
- Administration direction
Miglitol
- Give with 1st bite of meal
Januvia
- Frequency
- Caution SE:
- Use with Digoxin:
Sitagliptin Phosphate
- QD
- Can cause acute pancreatitis
- Use w/ digoxin: increase digoxin level
Onglyza
- Dose and frequency
- Strong inhibitor or Inducer?
Saxagliptin
- Dose: 2.5-5mg QD
- Strong inhibitor of 3A4/5
Tradjenta
- Dose
Linagliptin
- 5mg QD
- 3A4 substrate
Janumet
- Administration
Sitagliptin + Metformin
- Adm: with meal(s)
Jentadueto
- Administration
Linagliptin + Metformin
- Adm: BID w/ meals
Juvisync
Sitagliptin + Simvastatin
Nesina
- Caution SEs:
- DDI
**Alogliptin
- Pancreatitis, hypoG
- NO DDI.
Kazano
Alogliptin + Metformin HCl
Oseni
Alogliptin + Pioglitazone
Byetta
- Warning
Exenatide Injection
- Warning: acute renal failure/pancreatitis
- Report any abd pain
Bydureon
- Frequency
Exenatide ER
- 2mg powder injection weekly
Victoza
- Storage
- Open
- Unopened
- Color:
Liraglutide Pen
- Storage: Refrigerator for unopen.
Open @ RT for 30 days. Protect from light - Color: clear. do not use if not clear
Drugs belong to incretin enhancers
Byetta
Januvia
Onglyza
Victoza
Incretin Enhancers
Drugs help pt lose weight (incretin class)
Byetta
Victoza
Incretin Enhancers
Drugs that are neutral in weight
Januvia
Onglyza
Cause Pancreatitis
LEAS
- Sitagliptin
- Alogliptin
- Exenatide
- Linagliptin
Preg Cat B
- Linagliptin (tradjenta)
- Glyburide
- Metformin
Drugs in Na-G co-transporter 2 (SGLT2) inhibitor class:
- Canagliflozin (Invokana)
- Dapagliflozin (Farxiga)
Invokana
Invokamet
Canagliflozin
Canagliflozin/Metformin
Farxiga
Dapagliflozin
Invokana
- Indication
- MOA:
- Dosage form:
- Administration
GFR > 60:
GFR 45-59:
GFR
Canagliflozin
- Indication: Type II
- MOA: SGLT2 inhibitor => increase urinary glucose excretion
- Form: Film coated tabs
- Dose: initial 100 mg PO QD before 1st meal
GFR > 60: can incr dose to 300 mg QD
GFR 45-59: Max 100mg QD
GFR
Canagliflozin
- Caution
- Symptomatic hypoTN
- Increase SCr
- Increase K
- Increase LDL
- HypoG
- Genital fungal infection
Farxiga
- Indication
- MOA:
- Dosage form:
- Administration
GFR
Dapagliflozin
- Indication: type II DM
- MOA: SGLT2: increase urinary glucose excretion
- Form: tablet
- Dose: 5mg QD, QAM with or w/o food. Dose can be increase to 10mg QD if needed
- GFR
Santyl Ointment
- Indication
Collagenase
- FDA approves active enzymatic therapy that continuously removes necrotic tissue from wounds at the microscopic level, which allows new, healthy tissue to form.
SGLT2 => renal imp
- Which one should not use
- Which one need dose adj
- Not use: Farxiga (Dapagliflozin)
- Need dose adj: Invokana. Avoid when CrCl
Insulin dose
- Type I
- Type II
- Type I: 0.5-0.8u/kg
- Type II: 0.7-1.5u/kg
Manage hypoG in unconscious pt
- Glucagon: 1mg SC/IM/IV
- Glucose IV 10-25g 4 min followed by 5-10 g/hr until pt gain consciousness
Trulicity
- Class
- Frequency
Dulaglutide
- Class: GLP-1 Inhibitor
- Frequency: weekly
Jardiance
- Class
Empagliflozin
- Class: SGLLT-2 inhibitor
Riomet
Metformin oral sol’n 100mg/mL
Fortamet
- Form
- Max dose
Metformin ER
- Max dose: 2500mg/day
Glumetza
- Max dose:
Meformin
- Max Dose: 2g/d
Prandimet
- Administration
Repeglinide + Metformin
- Take 30 min before mal
- Skip meal, skip dose
Kombiglyze XR
- Frequency
Saxagliptin + metformin
- QD in the evening
Kazano
Alogliptin + Metformin
Invokamet
Canagliflozin + metformine
Xigduo XR
Dapagliflozin + metformin
Avandaryl
Rosiglitazone + Glimepiride
Tanzeum
- Class
- Frequency
Albiglutide
- Class: GLP-1 inhibitor
- Dose: weekly
Parlodel
- Indication
Bromocriptine
- Indication: Parkinson disease