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11. Diabetes Mellitus > Generic/Brand > Flashcards

Generic/Brand Flashcards

1
Q

Amaryl

A

Glimepiride

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2
Q

Glucotrol

A

Glipizide

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3
Q

DiaBeta

A

Glyburide micronase

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4
Q

Glynase

A

Glyburide micronized

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5
Q

Avandia

  • FDA removed restriction on
  • BBW
A

Rosiglitazone

  • FDA recently removed restriction below
  • Avandia-Rosiglitazone Medicines Access Program: will only be available thr a special mail-order. MDs and pts are enrolled. Special pharmacies are part of the program, and will be the only pharmacies that can mail the drugs
  • BBW: possible HF
  • can lead to ischemic HF
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6
Q

Actos

A

Pioglitazone

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7
Q

Precose

  • Administration
A

Acarbose

  • Give with 1st bite of meal
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8
Q

Starlix

  • Direction for administration
A

Nateglinide

  • Give 30 min b/4 meals
  • Skip meal/skip dose & add meal/add dose
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9
Q

Cycloset

  • Indication
A

Bromocriptine

  • Indication: DM
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10
Q

Afrezza

  • CI:
  • SEs
  • Storage
  • Exp at RT:
  • Exp of opened strips:
  • Cartridge:
A

RA insulin human inhalation powder

  • CI: any lung disease => lung cancer, asthma
  • SEs: HypoG, cough/bronchospasm, hypoK, fluid retention/HF
  • Storage: fridge
  • Exp at RT: 10 days
  • Exp of opened strips: 3 days
  • Cartridge: leave at RT x 10min before use
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11
Q

Humalog

  • Class
A

Lispro

  • RA insulin
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12
Q

Novolog

  • Class
A

Aspart

  • RA insulin
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13
Q

Apidra

  • Class
A

Glulisine

  • RA insulin can give IV in hospital w/ monitoring
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14
Q

Short Acting Insulin:

  • Drugs in this class
  • Appearance:
  • Expiration at RT
A

Regular insulin (OTC)

  • Humulin R => RT 31 days
  • Novolin R => RT 42 days
  • Appearance: clear
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15
Q

Intermediate Acting Insulin:

  • Drugs in this class
  • Appearance:
  • Expiration at RT
A

NPH (cloudy) (OTC)

  • Humulin N => RT Exp 31 days
  • Novolin N => RT Exp 42 days
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16
Q

Detemir

  • Frequency
  • Exp date at RT:
A

Levemir

  • Give BID
  • Exp in 42 days
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17
Q

Lantus

  • Frequency
  • Mixing direction
  • Exp date at RT:
A

Glargine

  • Give QD
  • NEVER mix w/ other insulins => pH is 4
  • Exp: 28 days
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18
Q

Symlin

  • Indication
  • Do not give
  • Dose
    Type I and Type II
  • MOA
  • SEs
  • Storage
  • Exp:
A

Pramlintide - Pen

  • Indication: postprandial glycemic control
  • Do not give to: hypersensitivity to metacresol preservative, gastroparesis or on GI motility med, on alpha glycosides inhibitors
  • Dose
    Type I: 15 mcg
    Type II: 60 mcg
  • MOA: increase AMYLIN = delay gastric emptying, inhibits postprandial glucose release, reduce appetite
  • SEs: HypoG, anorexia, wt loss, nausea
  • Storage: fridge
  • Exp: 30 days at RT
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19
Q

Diabinese

  • Class
A

Chlorpropamide

  • Class: 1st generation of Sulfonylureas
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20
Q

Tolinase

  • Class
A

Tolazemide

  • Class: 1st generation of Sulfonylureas
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21
Q

Orinase

  • Class
A

Tolbutamide

  • Class: 1st generation of Sulfonylureas
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22
Q

Glucophage

Glucophage XR

A

Metformin

  • Max dose:
    Glucophage 2550mg/d
    Glucophage XR: 2000mg/d
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23
Q

Glucovance (R)

A

Glyburide/Metformin

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24
Q

Avandamet (R)

A

Rosiglitazone/Metformin

  • Avandia = Rosiglitazone
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25
Q

Trajenta

Jentadueto

A

Linagliptin

Linagliptin/Metformin

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26
Q

Actoplus Met

A

Pioglitazone/Metformin

Actos = pioglitazone

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27
Q

Prandin

Prandimet

A

Repaglinide

Repaglinide/Metformin

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28
Q

Onglyza

Kombiglyze XR

  • Max dose
A

Saxagliptin

Saxagliptin/metformin ER

-Max dose: Max 5mg sax & 2000 mg ER metformin

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29
Q 
Avandia
===
Amaryl
===
Avandaryl
A 
Rosiglitazone
===
Glimepiride
====
Rosiglitazone and Glimepiride
30
Q

Prandin

  • Administration direction
A

Repaglinide

  • Give 15 min b/4 meal
  • Skip meal/skip dose & add meal/add dose
31
Q

Glyset

  • Administration direction
A

Miglitol

  • Give with 1st bite of meal
32
Q

Januvia

  • Frequency
  • Caution SE:
  • Use with Digoxin:
A

Sitagliptin Phosphate

  • QD
  • Can cause acute pancreatitis
  • Use w/ digoxin: increase digoxin level
33
Q

Onglyza

  • Dose and frequency
  • Strong inhibitor or Inducer?
A

Saxagliptin

  • Dose: 2.5-5mg QD
  • Strong inhibitor of 3A4/5
34
Q

Tradjenta

  • Dose
A

Linagliptin

  • 5mg QD
  • 3A4 substrate
35
Q

Janumet

  • Administration
A

Sitagliptin + Metformin

  • Adm: with meal(s)
36
Q

Jentadueto

  • Administration
A

Linagliptin + Metformin

  • Adm: BID w/ meals
37
Q

Juvisync

A

Sitagliptin + Simvastatin

38
Q

Nesina

  • Caution SEs:
  • DDI
A

**Alogliptin

  • Pancreatitis, hypoG
  • NO DDI.
39
Q

Kazano

A

Alogliptin + Metformin HCl

40
Q

Oseni

A

Alogliptin + Pioglitazone

41
Q

Byetta

  • Warning
A

Exenatide Injection

  • Warning: acute renal failure/pancreatitis
  • Report any abd pain
42
Q

Bydureon

  • Frequency
A

Exenatide ER

- 2mg powder injection weekly

43
Q

Victoza

  • Storage
    • Open
    • Unopened
  • Color:
A

Liraglutide Pen

  • Storage: Refrigerator for unopen.
    Open @ RT for 30 days. Protect from light
  • Color: clear. do not use if not clear
44
Q

Drugs belong to incretin enhancers

A

Byetta
Januvia
Onglyza
Victoza

45
Q

Incretin Enhancers

Drugs help pt lose weight (incretin class)

A

Byetta

Victoza

46
Q

Incretin Enhancers

Drugs that are neutral in weight

A

Januvia

Onglyza

47
Q

Cause Pancreatitis

A

LEAS

  • Sitagliptin
  • Alogliptin
  • Exenatide
  • Linagliptin
48
Q

Preg Cat B

A
  • Linagliptin (tradjenta)
  • Glyburide
  • Metformin
49
Q

Drugs in Na-G co-transporter 2 (SGLT2) inhibitor class:

A
  • Canagliflozin (Invokana)

- Dapagliflozin (Farxiga)

50
Q

Invokana

Invokamet

A

Canagliflozin

Canagliflozin/Metformin

51
Q

Farxiga

A

Dapagliflozin

52
Q

Invokana

  • Indication
  • MOA:
  • Dosage form:
  • Administration
    GFR > 60:
    GFR 45-59:
    GFR
A

Canagliflozin

  • Indication: Type II
  • MOA: SGLT2 inhibitor => increase urinary glucose excretion
  • Form: Film coated tabs
  • Dose: initial 100 mg PO QD before 1st meal
    GFR > 60: can incr dose to 300 mg QD
    GFR 45-59: Max 100mg QD
    GFR
53
Q

Canagliflozin

  • Caution
A
  • Symptomatic hypoTN
  • Increase SCr
  • Increase K
  • Increase LDL
  • HypoG
  • Genital fungal infection
54
Q

Farxiga

  • Indication
  • MOA:
  • Dosage form:
  • Administration
    GFR
A

Dapagliflozin

  • Indication: type II DM
  • MOA: SGLT2: increase urinary glucose excretion
  • Form: tablet
  • Dose: 5mg QD, QAM with or w/o food. Dose can be increase to 10mg QD if needed
  • GFR
55
Q

Santyl Ointment

  • Indication
A

Collagenase

  • FDA approves active enzymatic therapy that continuously removes necrotic tissue from wounds at the microscopic level, which allows new, healthy tissue to form.
56
Q

SGLT2 => renal imp

  • Which one should not use
  • Which one need dose adj
A
  • Not use: Farxiga (Dapagliflozin)

- Need dose adj: Invokana. Avoid when CrCl

57
Q

Insulin dose

  • Type I
  • Type II
A
  • Type I: 0.5-0.8u/kg

- Type II: 0.7-1.5u/kg

58
Q

Manage hypoG in unconscious pt

A
  • Glucagon: 1mg SC/IM/IV

- Glucose IV 10-25g 4 min followed by 5-10 g/hr until pt gain consciousness

59
Q

Trulicity

  • Class
  • Frequency
A

Dulaglutide

  • Class: GLP-1 Inhibitor
  • Frequency: weekly
60
Q

Jardiance

  • Class
A

Empagliflozin

  • Class: SGLLT-2 inhibitor
61
Q

Riomet

A

Metformin oral sol’n 100mg/mL

62
Q

Fortamet

  • Form
  • Max dose
A

Metformin ER

  • Max dose: 2500mg/day
63
Q

Glumetza

  • Max dose:
A

Meformin

  • Max Dose: 2g/d
64
Q

Prandimet

  • Administration
A

Repeglinide + Metformin

  • Take 30 min before mal
  • Skip meal, skip dose
65
Q

Kombiglyze XR

  • Frequency
A

Saxagliptin + metformin

  • QD in the evening
66
Q

Kazano

A

Alogliptin + Metformin

67
Q

Invokamet

A

Canagliflozin + metformine

68
Q

Xigduo XR

A

Dapagliflozin + metformin

69
Q

Avandaryl

A

Rosiglitazone + Glimepiride

70
Q

Tanzeum

  • Class
  • Frequency
A

Albiglutide

  • Class: GLP-1 inhibitor
  • Dose: weekly
71
Q

Parlodel

  • Indication
A

Bromocriptine

  • Indication: Parkinson disease

11. Diabetes Mellitus (1 decks)

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