Generalisability

Question 1

Population aspect

Answer 1

Population very specific or representative of the general population who have the disease?

Question 2

Intervention aspect

Answer 2

Intervention acceptable for pts? Require frequent follow ups? Unmanageable side effects?

Question 3

Control aspect

Answer 3

Compared to the gold standard?

Question 4

NNT aspect

Answer 4

NNT: The number you need to treat to prevent one additional bad outcome. If this is high, you might subject many patients to side effects with little positive impact.

Question 5

NNH aspect

Answer 5

NNH: The measure of harm caused by an intervention. A treatment will not be acceptable if it has a high morbidity/mortality associated with it.

Question 6

Financial aspect

Answer 6

What is the financial cost of treatment? UK finding of therapies determined by NICE and is heavily influenced by the Quality Adjusted Life Years (QALYs) that the treatment will bring.