General terms Flashcards
1
Q
Acetophenone
A
2
Q
Chalcone
A
3
Q
Aldol Addition
A
4
Q
LAG
A
liquid-assisted grinding
5
Q
Guanidine
A
6
Q
Sulfonyl group
A
7
Q
Imide
A
8
Q
What is η?
A
η refers to the volume of liquid per total mass of reagents
(η = µL per mg)
9
Q
sulfoxide
A
10
Q
Sorafenib
A
Sorafenib, sold under the brand name Nexavar,[3] is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma.
(trifluoromethylated drug)
11
Q
Phthalimide
A
12
Q
Isocyanate
A
R−N=C=O
13
Q
Carbamoyl
A
14
Q
Isatin
A
15
Q
Quinone
A
16
Q
Semiquinone
A
17
Q
Curtius rearrangement
how can you react the product? 3 possibilities
A
18
Q
Pivalic acid
A
PivOH
19
Q
Phosphate
A
20
Q
Phosphonate
A
21
Q
Phosphine
A
Also phosphane
22
Q
Phosphine oxide
A
23
Q
phosphinic acid
A
Hypophosphorous acid
24
Q
imine
A
25
Knoevenagel condensation
26
Dichotomy
a division or contrast between two things that are or are represented as being opposed or entirely different.
27
Michael Addition
28
azo group
29
What does aza- mean?
The prefix aza- is used in organic chemistry to form names of organic compounds where a carbon atom is replaced by a nitrogen atom. The related term "deaza-" refers to when a nitrogen is removed and, usually, a carbon atom is put in its place. Sometimes a number between hyphens is inserted before it to state which atom the nitrogen atom replaces. It arose by shortening the word azote, which is an obsolete name for nitrogen in the English language and occurs in current French usage (azote), meaning "nitrogen".
30
Azide
31
Sandmeyer reaction
diazonium salt
32
Ehylene oxide
33
THF
tetrahydrofuran
34
Furan
35
tetrahydropyran
36
4h-pyran
37
1,4 dioxane
38
ethylene imine
39
pyrrolidine
40
pyrrole
41
imidazole
42
pyrazole
43
triazole
44
piperidine
45
pyridine
46
pyrimidine
47
pyridazine
48
pyrazine
49
ethylene sulfide
50
tetrahydrothiophene
51
thiophene
52
tetrahydrothiopyran
53
Oxazole
54
thiazole
55
morpholine
56
Wittig reaction
57
Koch reaction
58
Selectfluor
Selectfluor, a trademark of Air Products and Chemicals, is a reagent in chemistry that is used as a fluorine donor. This compound is a derivative of the nucleophillic base DABCO. It is a colourless salt that tolerates air and even water. It has been commercialized for use for electrophilic fluorination.
59
DABCO
60
MTBE
Methyl tert-butyl ether
61
Duff reaction
62
Langlois reagent
Sodium trifluoromethanesulfinate
63
NFSI
N-Fluorobenzenesulfonimide
N-Fluorobenzenesulfonimide (NFSi) is a commonly used electrophilic fluorinating agent in organic synthesis to introduce fluorine into neutral organic molecules. It is also used to fluorinate nucleophilic substrates such as reactive organometallic species and malonate anions.[1][2]
NFSi can be synthesized by the reaction of benzenesulfonimide with fluorine.[
64
Koser's reagent
65
Ylide
An ylide (/ˈɪlaɪd/)[1] or ylid (/ˈɪlɪd/) is a neutral dipolar molecule containing a formally negatively charged atom (usually a carbanion) directly attached to a heteroatom with a formal positive charge (usually nitrogen, phosphorus or sulfur), and in which both atoms have full octets of electrons. The result can be viewed as a structure in which two adjacent atoms are connected by both a covalent and an ionic bond; normally written X+–Y−. Ylides are thus 1,2-dipolar compounds, and a subclass of zwitterions.[2] They appear in organic chemistry as reagents or reactive intermediates.[3]
66
mCPBA
meta-Chloroperoxybenzoic acid (mCPBA or mCPBA) is a peroxycarboxylic acid. It is a white solid often used widely as an oxidant in organic synthesis. mCPBA is often preferred to other peroxy acids because of its relative ease of handling.[1] mCPBA is a strong oxidizing agent that may cause fire upon contact with flammable material.
67
DBN
1,5-Diazabicyclo[4.3.0]non-5-ene (DBN) is a chemical compound with the formula C7H12N2.[1] It is an amidine base used in organic synthesis. A related compound with related functions is 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU). The relatively complex nature of the formal names for DBU and DBN (hence the common use of acronyms) reflects the fact that these compounds are bicyclic and contain several functional groups.
68
Differences of innate trifluoromethylation and programmed trifluoromethylation
Methodologies for the trifluoromethy-lation of arenes can be divided into two general categories(Fig. 1A): those that functionalize the inherently reactive posi-tions of the substrate (“innate trifluoromethylation”) and thosethat utilize substrate prefunctionalization or a directing group(“programmed trifluoromethylation”). For most applications,“programmed”aryl trifluoromethylation holds a distinct advan-tage because it can selectively functionalize positions that arenot naturally reactive
69
putative
mutmasslich, angeblich
70
TMSCF3
Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF3) is an organosilicon compound with the formula CF3Si(CH3)3. It is a colorless liquid. The compound is a reagent used in organic chemistry for the introduction of the trifluoromethyl group. The compound was first prepared in 1984 by Ingo Ruppert[1] and further developed as a reagent by G. K. Surya Prakash
71
Koenen Test
https://smsenergetics.com/koenen
72
Isocyanide
73
TBAI
74
triflic acid
75
TCCA
76
dipea
77
TMP
78
Wolff-Kishner reduction
79
Tosyl group
80
CF3SO2Cl
Trifluoromethanesulfonyl Chloride
triflyl chloride
81
K2S2O8
Potassium persulfate
82
Bronsted acidic togni activation:
give the mechanism!
83
Lewis acidic activation of Togni
give the mechanism
84
TTMSSCl
tris(trimethylsilyl)silyl chloride
85
Radical activation of the togni reagent
https://pubs.acs.org/doi/full/10.1021/acs.accounts.7b00148
86
Zhdankin reagent
87
Cu-Catalyzed Allylic Trifluoromethylation
mechanism
88
Benziodoxoles
89
Iodonium Ylides
90
Iodonium salts
91
TMSCF3
Trifluoromethyltrimethylsilane (known as Ruppert-Prakash reagent, TMSCF3
92
