General Surgery Flashcards

1
Q

What features should be noted on INSPECTION of mass?

A
Site
Shape
Size
Symmetry
Skin changes (e.g. erythema, swelling)
Scars present
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2
Q

What features should be noted on PALPATION of a mass?

A
Temperature
Tenderness
Translucency 
Colour
Attachments
Mobility 
Pulsations
Fluctuation
Irreducibility 
Regional lymph nodes
Edges
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3
Q

Risk factors for GALLBLADDER DISEASE?

A
✔️ female
✔️ aged > 40 years
✔️ obesity
✔️ rapid weight loss / weight gain
✔️ prolonged starvation
✔️ pregnancy
✔️ nephrotic syndrome, hypothyroidism (promote hypercholesterolemia)
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4
Q

What are the components of CHARCOT’S TRIAD?

A

✔️ jaundice
✔️ RUQ pain
✔️ fever

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5
Q

What are the components of REYNOLD’S PENTAD?

A
✔️ jaundice 
✔️ RUQ pain
✔️ fever
✔️ shock 
✔️ altered mental status
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6
Q

Describe the procedure of LAPAROSCOPIC CHOLECYSTECTOMY.

A
  1. Performed under general anaesthetic.
  2. Abdomen is washed with antiseptic wash (e.g. chlorhexadine)
  3. Three small incisions are made in the abdomen (umbilicus and lower quadrants) to allow for insertion of a small camera and tools for the procedure.
  4. The abdomen is inflated with gas to allow visualisation of organs.
  5. The cystic artery and the cystic duct are identified and clamped. Intra-operative cholangiogram (X-Ray) allows for visualisation of these vessels.
  6. Once visualised, the vessels are ligated and the gallbladder is removed.
  7. A drain may be put in place to assist with drainage of residual fluid.
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7
Q

What are the risks associated with LAPAROSCOPIC CHOLECYSTECTOMY?

A
ANASTHETIC RISKS
✔️ damage to teeth and airways
✔️ cardiovascular and respiratory complications
✔️ anaphylaxis / allergy to medications
✔️ malignant hyperthermia
INTRA-OPERATIVE RISKS
✔️ bleeding (rare)
✔️ bile duct damage
✔️ damage to other surrounding organs (e.g. bowel)
✔️ infection
✔️ conversion to open
EARLY POST-OP RISKS
✔️ pain
✔️ nausea and vomiting
✔️ lung infection + collapse
✔️ DVT + PE
✔️ infection of surgical site
✔️ bile leak
LATE POST-OP RISKS
✔️ adhesions
✔️ bowel obstruction
✔️ hernia
✔️ bile duct fibrosis
✔️ bile reflex --> chronic liver disease
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8
Q

What are the three main causes of small bowel obstruction?

A
  1. adhesions (usually secondary to previous abdominal surgery)
  2. hernias (usually internal)
  3. carcinoma
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9
Q

Describe the clinical presentation of bowel obstruction.

What symptoms are suggestive of perforation / peritonitis?

A
CLINICAL FEATURES
✔️ acute onset, colicky abdominal pain
✔️ nausea + vomiting (feculant vomiting is a late-sign)
✔️ constipation
✔️ nil flatus
✔️ increasing abdominal distension
PERFORATION
✔️ severe abdominal pain
✔️ fever
✔️ tachycardia / tachyponea
✔️ bounding pulse / wide pulse pressure (suggestive of sepsis)
✔️ rigid abdomen + abdominal guarding
✔️ tinkling bowel sounds
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10
Q

Outline appropriante investigations for SMALL BOWEL OBSTRUCTION and the indication for each.

A

BEDSIDE Ix
✔️ ABG –> metabolic acidosis
✔️ ECG –> monitor electrolyte abnormalities leading to arrythmia
✔️ blood glucose level

LABORATORY Ix
✔️ FBC + WCC –> leucocytosis
✔️ UECs –> base line renal function (AKI is a complication)
✔️ LFTs –> in case of surgery
✔️ coags –> in case of surgery
✔️ group and hold + cross match (in case of surgery)

IMAGING
✔️ abdominal X ray
✔️ abdominal CT –> to look for complications such as perforation, bowel wall ischemia, bowel wall necrosis
✔️ gastrograffin challenge (via NGT or PO)

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11
Q

What are the findings of SBO on abdominal X ray?

A
  1. dilation of bowel loops > 3cm (proximal) with collapse of bowel distal to obstruction
  2. absence of haustra
  3. centrally located
  4. air fluid levels
  5. air beneath diaphragm suggestive of perforation
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12
Q

Explain the purpose / use of GASTROGRAFFIN in the diagnosis of SBO.

A

Gastrograffin is a water-soluble contrast agent that has both diagnostic and therapeutic use in the management of adhesional SBO, specifically.

GGF is given via NGT or orally. An abdominal X ray is taken at the time of administration. A repeat abdominal X ray is performed 6 to 24 hours after administration.

If GGF is seen in the cecum, it suggests a PARTIAL aSBO. This is highly likely to resolve spontaneously.

If GGF is NOT seen in the cecum, it suggests a COMPLETE / COMPLICATED aSBO. These findings are less supportive of spontaneous resolution; surgical intervention is more likely to be required.

N.B. It is extremely important that all patients with query SBO undergo abdominal CT prior to GGF. This is to check for complications (e.g. perforation, necrosis, ischemia, closed loop obstruction) and to identify an underlying cause for the obstruction other than adhesions (e.g. hernia, malignancy, volvulus).

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13
Q

Describe the MEDICAL MANAGEMENT of SBO.

A
✔️ primary survey (ABCDE)
✔️ commence IV fluids (0.9% NaCl)
✔️ appropriate analgesia
✔️ keep NBM
✔️ insert NGT (gastric decompression)
✔️ surgical referral 
✔️ monitor for ongoing changes and signs of surgical intervention (i.e. perforation, bowel wall necrosis, bowel wall ischemia)
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14
Q

What are the indications for SURGICAL INTERVENTION of SBO and what does the procedure involve?

A
INDICATIONS:
✔️ bowel wall ischemia 
✔️ bowel wall necrosis 
✔️ perforation --> peritonism
✔️ closed loop obstruction

Surgical management of SBO involves resection of non-viable bowel and re-anastomosis. If re-anastomosis is not possible, a stoma may have to be formed.

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15
Q

Identify the MECHANICAL and FUNCTIONAL causes of large bowel obstruction.

A

MECHANICAL CAUSES
✔️ colorectal carcinoma (sigmoid colon)
✔️ sigmoid volvulus
✔️ diverticular disease

FUNCTIONAL CAUSES
✔️ toxic megacolon (secondary to ulcerative colitis of C. difficle infection)
✔️ hypokalaemia and other electrolyte disturbances
✔️ hypothyroidism
✔️ Parkinson’s disease
✔️ severe Type 2 DM (autonomic neuropathy)
✔️ spinal cord dysfunction

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16
Q

What are the findings of LBO on abdominal X ray?

A
  1. dilated bowel loops > 6cm proximal to obstruction + collapsed bowel loops distal to obstruction
  2. haustra
  3. peripherally located
  4. air fluid levels
  5. free air under diaphragm in the case of perforation
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17
Q

What is HARTMANN’S PROCEDURE and when is it indicated?

A

Hartmann’s procedure involves resection of unviable bowel + formation of sigmoid colostomy + sewing over of the rectal stump.

This procedure is indicated in:

  1. obstructing malignancy
  2. uncontrolled diverticular bleeding
  3. perforation
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18
Q

What is SIGMOID DECOMPRESSION and when is it indicated?

A

Sigmoid decompression is indicated as soon as sigmoid volvulus is identified as the cause of LBO on gastrograffin enema.

This procedure involves passing a flexible sigmoidoscope or colonoscope and decompressing the sigmoid colon.

If unsuccessful, a flatus tube may have to be passed through the sigmoid colon to stent it.

Recurrence occurs in ~50% of cases.

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19
Q

RIGHT HEMICOLECTOMY
✔️ indications
✔️ organs removed

A

INDICATIONS
✔️ cecal tumours
✔️ ascending colon tumours
✔️ transverse colon tumours

ORGANS REMOVED
✔️ cecum
✔️ appendix
✔️ ascending colon
✔️ proximal transverse colon
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20
Q

LEFT HEMICOLECTOMY
✔️ indications
✔️ organs removed

A

INDICATIONS
✔️ transverse colon tumours
✔️ descending colon tumours

ORGANS REMOVED
✔️ transverse and descending colon

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21
Q

SIGMOIDCOLECTOMY
✔️ indications
✔️ organs removed

A

✔️ sigmoid colon tumours

The sigmoid colon only is removed.

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22
Q

ANTERIOR RESECTION
✔️ indications
✔️ organs removed

A

INDICATIONS
✔️ high rectal tumours (>5cm above the anus)

ORGANS REMOVED
✔️ sigmoid colon
✔️ rectum

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23
Q

ABDOMINAL PERINEAL RESECTION
✔️ indications
✔️ organs removed

A

INDICATIONS
✔️ distal rectal tumours (<5cm above the anus)

ORGANS REMOVED
✔️ sigmoid colon
✔️ rectum
✔️ anus
✔️ anal sphincters
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24
Q

Outline appropriante follow up for patients with colorectal cancer.

A

CEA and physical exam every 3 to 6 months
Abdominal and Chest CT every 6 to 12 months
Colonoscopy every 12 months

This should occur for five years follow surgery.

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25
Q
ANAL FISSUE
✔️ description / pathophysiology
✔️ risk factors
✔️ clinical presentation
✔️ management
A

DESCRIPTION / PATHOPHYSIOOGY
Anal fissure is a tear in the mucosal lining of the anus. It is believed to be a complication of chronic constipation which leads to chronic inflammation of the anus.

Hypertonia of the internal anal sphincter is also a contributing factor –> leads to high intra-anal pressure at rest.

The fissure is seen between the dentate line and the anal orifice.

RISK FACTORS
✔️ chronic constipation
✔️ chronic diarrhoea
✔️ dehydration
✔️ inflammatory bowel disease

CLINICAL PRESENTATION
Anal fissure typically presents with excruciating pain during and just after defection.

Associated symptoms may include:
✔️ PV bleeding
✔️ itching
✔️ anal pain at rest

MANAGEMENT
Conservative management includes: 
✔️ local anaesthetic
✔️ hydrocortisone creme 
✔️ high fibre diet

Surgical management requires lateral internal anal sphincterotomy.
✔️ 3% risk of recurrence
✔️ fecal incontinence is ongoing issue / risk

26
Q
PILONIDAL SINUS
✔️ description / pathophysiology
✔️ risk factors
✔️ clinical presentation
✔️ management
A

DESCRIPTION / PATHOPHYSIOLOGY
A sinus is a blind pouch.

Pilonoidal sinus is seen in the intergluteal cleft. It is believed to be due to occlusion of the pilonidal hair shaft with a follicle. This obstructs the shaft outlet, leading to inflammation. Secondary bacterial inflammation may contribute to ongoing symptoms.

RISK FACTORS
✔️ male
✔️ aged 16 to 35 years
✔️ coarse, dark hair
✔️ obesity
✔️ sweating
✔️ occupation that requires sitting (e.g. truck driver)

CLINICAL PRESENTATION
✔️ pain in inter-gluteal area whilst sitting
✔️ associated with swelling, tenderness, erythema, itch in the area

MANAGEMENT
Conservative management includes:
✔️ encourage plucking or shaving of hairs in the area
✔️ maintain good hygiene

Surgical management is usually only indicated if abscess formation occurs.
✔️ incision and drainage
✔️ IV antibiotics
✔️ oral antibiotics after procedure (reduce risk of abscess / fistular formation)

27
Q
PERIANAL ABSCESS
✔️ description / pathophysiology
✔️ risk factors
✔️ clinical presentation
✔️ management
A

DESCRIPTION / PATHOPHYSIOLOGY
Perianal abscess formation is due to occlusion of anal glands (crypto glandular theory).

Occlusion of gland promotes inflammation. Superficial bacterial infection worsens this.

RISK FACTORS
✔️ type 2 diabetes mellitus
✔️ immunosuppresion
✔️ inflammatory bowel disease

CLINICAL PRESENTATION
Typically, perianal abscess presents with pain on sitting. Erythema, swelling and itchy may be noted in the area.

MANAGEMENT
✔️ proctoscopy is necessary to identify fistula formation
✔️ incision + drainage of abscess is required
✔️ IV antibiotics / oral antibiotics to prevent fistula formation

COMPLICATIONS
One-third of patients with perianal abscess present with fistula.

28
Q

What are some differentials for “bottom pain?”

A
✔️ anal fissue
✔️ pilonoidal sinus
✔️ perianal abscess
✔️ perianal fistula
✔️ pruritis ani
29
Q

Define HERNIA.

A

A hernia is protrusion of viscera through the wall in which the viscera is meant to be contained.

In terms of an abdominal hernia, this means protrusion of bowel contents through the abdominal wall.

30
Q

Compare DIRECT versus INDIRECT inguinal hernia.

A

INDIRECT INGUINAL HERNIA
✔️ congenital / inherited
✔️ occurs in younger men
✔️ appears lateral and superior to the inferior epigastric vessels
✔️ due to a patient processus vaginalis –> enables contents of the bowel to descend through the inguinal canal via the deep inguinal ring

DIRECT INGUINAL HERNIA
✔️ acquired
✔️ occurs in older men
✔️ appears medial and inferior to the inferior epigastric vessels (within Hasselbach’s triangle)
✔️ due to (1). weakening of the abdominal muscles and (2). increased intra-abdominal pressure

31
Q

Identify the borders / boundaries of Hasselbach’s Triangle.

A

INFERIOR - inguinal ligament

SUPERIOR - inferior epigastric vessels

MEDIAL - abdominal rectus muscle

32
Q

What are key enquiries regarding hernia that need to be enquired about on history?

A
✔️ duration --> acute versus chronic
✔️ size --> increasing or stable
✔️ irreducibility (positional changes)
✔️ pain + tenderness
✔️ swelling
✔️ erythema
✔️ signs of bowel obstruction (e.g. vomiting, constipation, increasing abdominal distension)
✔️ risk factors for hernia (e.g. previous abdominal surgery, chronic constipation, heavy lifting)
33
Q

Identify and define three indications for emergency hernia repair.

A
  1. irreducibility –> the contents of the hernia are unable to be pushed back into the abdominal cavity
  2. obstruction –> the neck of the hernia is obstructing the contents; presents similar to bowel obstruction
  3. strangulation –> the blood supply to the hernial components is compromised, leading to ischemia
34
Q

Outline differential diagnoses for GROIN LUMP.

A

✔️ hernia (indirect or direct)
✔️ inguinal lymphadenopathy
✔️ lipoma
✔️ femoral artery / inguinal artery aneurysm

35
Q

Describe NON-PHARMACOLOGICAL / MEDICAL management for hernia.

A

Non-complicated hernias (i.e. nil strangulation, obstruction, irreducibility) do NOT require emergency surgery.

Management should include: 
✔️ weight loss
✔️ smoking cessation
✔️ reduce alcohol consumption
✔️ avoid heavy lifting
✔️ treat constipation as appropriate
36
Q

What are the two types of hernia repair?

A
  1. total extra-peritoneal (TEP) repair

2. trans-abdominal pre-peritoneal repair (TAPP)

37
Q

Identify risks associated with hernia repair surgery.

A
ANASTHETIC RISKS
✔️ damage to airways, teeth, neck, jaw etc.
✔️ cardiorespiratory complications
✔️ anaphylaxis / allergies
✔️ dry mouth / hoarseness of voice
INTRA-OPERATIVE
✔️ damage to surrounding structures (e.g. bladder, bowel, other abdominal organs)
✔️ bleeding
✔️ infection
✔️ need to convert to open
POST-OPERATIVE (EARLY)
✔️ pain
✔️ nausea and vomiting
✔️ pulmonary infection + atelectasis 
✔️ DVT + PE
ONGOING COMPLICATIONS
✔️ recurrence
✔️ new hernia
✔️ adhesions --> increased risk of SBO
✔️ pain
✔️ injury to vas deferens and testicular vessels --> testicular atrophy and sub-fertility
38
Q

Outline differential diagnosis for SCROTAL MASS.

A
EXTRA-TESTICULAR
✔️ hydrocele (primary or secondary to infection, trauma, tumour)
✔️ varicocele
✔️ inguinal hernia
✔️ epididymal cyst
✔️ epididymitis

INTRA-TESTICULAR
✔️ testicular mass / cancer
✔️ orchitis
✔️ testicular torsion

39
Q

HYDROCELE
✔️ pathophysiology
✔️ symptoms
✔️ clinical findings

A

PATHOPHYSIOLOGY
Hydrocele is a collection of fluid between the visceral and parietal layer of the testes.

In men, hydroceles can be primary (idiopathic) or occur secondarily to trauma, tumour or infection.

SYMPTOMS
✔️ unilateral scrotal mass
✔️ enlarging
✔️ non-tender –> may be uncomfortable to walk / sit

CLINICAL FINDINGS
✔️ testes not palpable
✔️ transilluminate

40
Q

VARICOCELE
✔️ pathophysiology
✔️ symptoms
✔️ clinical findings

A

PATHOPHYSIOLOGY
Varicocele is dilatation of the pampiniform plexus of veins that drains the testes. The exact cause is unknown. Most commonly occurs on the left-hand-side.

SYMPTOMS
✔️ feels like a "bag of worms"
✔️ unilateral scrotal swelling
✔️ non-painful
✔️ disappears when lying down

CLINICAL FEATURES
✔️ testes not palpable
✔️ does NOT transilluminate

Varicocele can lead to testicular atrophy and infertility if severe.

41
Q

EPIDIDYMAL CYST
✔️ pathophysiology
✔️ symptoms
✔️ clinical findings

A

PATHOPHYSIOLOGY
Epididymal cyst is a fluid-filled cyst located on the epididymis. The exact pathophysiology is unknown.

SYMPTOMS
✔️ unilateral
✔️ not painful

CLINICAL FINDINGS
✔️ testes palpable
✔️ transilluminate

42
Q

EPIDIDYMOORCHITIS
✔️ pathophysiology
✔️ symptoms
✔️ clinical features

A

PATHOPHYSIOLOGY
Epididymo-orchitis is inflammation of the epididymis + testes (commonly occur together).

In younger men, it is commonly caused by STIs (e.g chlamydia, gonorrhoea).

In order men, it is most commonly caused by UTIs (e.g. E. coli).

SYMPTOMS
✔️ acute onset, unilateral scrotal pain
✔️ low grade fever
✔️ symptoms of underlying pathology (e.g. discharge, LUTS)

CLINICAL FEATUTES
✔️ Phren’s Sign +ve (relief with pain when the scrotum is elevated)
✔️ Cremesteric Reflex +ve (scrotum contracts when the inner thigh is stroked)

Management involves analgesia and appropriate antibiotics.

43
Q

TESTICULAR TORSION
✔️ pathophysiology
✔️ symptoms
✔️ clinical features

A

PATHOPHYSIOLOGY
Testicular torsion is most common in boys in early puberty. It is due to twisting of the testes on the spermatic cord, leading to impaired venous drainage, swelling, oedema and ischemia.

SYMPTOMS
✔️ acute onset, unilateral scrotal pain
✔️ nausea + vomiting

CLINICAL FEATURES
✔️ Phren’s reflex -ve
✔️ cremestatic reflex -ve

Management involves analgesia and urgent surgical referral –> salvage within 6 hours of symptom onset is required to avoid risk of testicular death.

44
Q

Differential diagnosis for BREAST LUMP?

A
BENIGN CAUSES
✔️ fibroadenoma
✔️ fibrocystic disease
✔️ lipoma
✔️ Phyllodes tumour
✔️ ductal echlasia 
✔️ mastitis / infection

MALIGNANT CAUSES
✔️ ductal carcinoma in situ
✔️ locular carcinoma in situ
✔️ invasive carcinoma (ductal or lobular)
✔️ lymphoma
✔️ secondary breast cancer (distant metastasis)

45
Q

Outline the components of TRIPLE ASSESSMENT.

A

CLINICAL ASSESSMENT
✔️ history
✔️ examination

IMAGING
✔️ USS –> indicated in women < 35 years and males
✔️ mammogram –> indicated in women > 35 years (micro calcifications)

HISTOLOGY
✔️ fine needle aspirate (FNA) –> cytology
✔️ core biopsy –> histology

Hormonal markers (estrogen, progesterone and HER2 receptor status) are also important.

46
Q

What are indications for a TOTAL MASTECTOMY?

A
✔️ large tumour size relative to breast size
✔️ nipple involvement
✔️ recurrent breast disease
✔️ invasive disease
✔️ women choose not to have BCS

Total mastectomy involves removal of breast tissue, nipple and axillary lymph nodes.

Post-operative radiotherapy is also common to reduce risk of recurrence.

47
Q

What are contraindications for BREAST CONSERVATION SURGERY (BCS)?

A

✔️ unable to have radiotherapy (e.g. pregnant)
✔️ multi-centric disease
✔️ recurrent disease within the same breast

BCS involves wide local excision of the cancer +/- removal of the sentinel lymph node.

48
Q

Outline the appropriate follow up for BCS.

A

Physical examination every 6 months for 5 years PLUS
Mammogram every 12 months for 5 years

And then yearly afterwards.

49
Q

Outline the procedure of SENTINEL LYMPH NODE BIOPSY (SLNB).

A

SLNB is a procedure in which the sentinel lymph node (i.e. the lymph node draining the cancer) is identified and removed.

A radioactive agent / blue dye is injected adjacent to the cancer. This is used to identify the lymph node draining the cancer. It is removed and analysed by a pathologist for cancerous cells.

If cancerous cells are present, other lymph nodes may also be removed.

50
Q

What are TWO examples of biological agents used in the treatment of breast cancer?

A

Tamoxifen (selective estrogen receptor modulator)

Trastuzimab (HER2 receptor antagonist)

51
Q

Outline complications of breast surgery.

A
✔️ psychological complications / concerns
✔️ recurrence of disease
✔️ scarring
✔️ breast hematoma
✔️ infection
✔️ pain and numbness of the upper medial arm and chest wall (due to intercostal brachial nerve damage)
✔️ limitation of shoulder movement
✔️ lymphoedema
52
Q

What disease are implicated in MEN1 and MEN2 syndrome?

A

MEN1
✔️ parathyroid tumour
✔️ pituitary tumour
✔️ pancreatic tumour

MEN2a
✔️ parathyroid tumour
✔️ medullary thyroid tumour
✔️ phaeochromocytoma

53
Q

Differential diagnosis for NECK LUMP.

A
INFECTIVE
✔️ EBV
✔️ CMV
✔️ mumps virus
✔️ reactive lymph adenitis

CONGENITAL
✔️ thyroglossal cyst
✔️ hypoglossal cyst
✔️ dermal cyst

THYROID
✔️ multi nodular goitre
✔️ toxic nodule
✔️ thyroid cancer

VASCULAR
✔️ carotid body tumour
✔️ carotid body aneurysm

54
Q

What investigations are required the context of NECK LUMP.

A
✔️ FBC + WCC
✔️ Inflammatory markers
✔️ TFTs
✔️ CMP
✔️ serum calcitonin levels
✔️ Viral serology (EBV, mumps)
✔️ radioactive iodine test (only if hyperthyroidism)
✔️ neck USS (microcalcifications, hypoechogenicity, irregular margins)
55
Q

What is the classification system used for USS of NECK LUMP.

A

U1 and U2 require no further investigation.

U3, U4 and U5 should have FNAC.

56
Q

What is the classification system used for FNAC of NECK LUMPS.

A

Thy1 = inconclusive

Thy2 = benign; cancer unlikely. No further Ix required.

Thy3 = follicular; diagnostic hemithyroidectomy required.

Thy4 = suspicious; diagnostic hemithyroidectomy required.

Thy5 = malignancy highly likely; total thyroidectomy required.

57
Q

What are the complications of thyroidectomy?

A

✔️ hematoma formation (may require cricothyrotomy on the ward)
✔️ damage to recurrent laryngeal nerve –> vocal cord paralysis (unilateral) or total airway obstruction (bilateral)
✔️ hypocalcemia, resulting in tetany and parasthetis (due to removal of parathyroid gland)
✔️ lifelong thyroid hormone replacement required

58
Q

Which organisms are commonly involved in NECROTISING FASCIITIS?

A

TYPE 1 - polymicrobial

TYPE 2 - GAS, Staph. aureus

TYPE 3 - Clostridium species

OTHER - Vibrio species, Aereomonus hydrophilia, fungal

59
Q

What are some risk factors for NECROTISING FASCIITIS?

A
✔️ immunocompromised 
✔️ Type 2 DM
✔️ alcohol use
✔️ drug use (IVDU)
✔️ malignancy
✔️ increasing age
✔️ aspirin and other NSAIDs
60
Q

Management of necrotising fasciitis?

A
  1. primary survey (ABCDE)
  2. collect appropriante bloods and wound swab
  3. commence appropriante analgesia
  4. commence IV antibiotics (penicillin, cephalosporins, clindamycin, metronidazole, carbepenem, vancomycin)–> adjust once culture returned
  5. keep NBM
  6. IV fluids
  7. urgent surgical referral –> urgent surgical debridement of necrotic tissue
  8. consider hyperbaric therapy + immunoglobulins