General Review

Question 1

What 2 medications cause genital and anal burning?

Answer 1

1. Fospropofol
2. Dexamethasone

Question 2

Which opioids are Phenylpiperidines?

Answer 2

1. Alfentanil
2. Fentanyl
3. Remifentanil
4. Sufentanil

Question 3

Which opioids have histamine release?

Answer 3

1. Meperidine
2. Morphine
3. Codeine

Question 4

Which opioids have an active metabolite?

Answer 4

1. Meperidine (Normeperidine)
2. Morphine (morphine-6-glucuronide)

Question 5

Which opioids are longer acting?

Answer 5

1. Morphine (4-5 hours)
2. Hydromorphone (4-5 hours)
3. Meperidine (2-4 hours)
4. Sufentanil? (dose-dependent, 1/2 life=6 hours)

Question 6

Which opioids are short acting?

Answer 6

1. Alfentanil (brief)
2. Remifentanil (5-10 minutes)
3. Fentanyl (0.5-1 hour)

Question 7

Which opioids are not metabolized by the liver P450 enzymes?

Answer 7

1. Morphine (glucuronidation)
2. Hydromorphone (glucuronidation)
3. Remifentanil (plasma esterases)

Question 8

Which opioid leads to an increased risk of serotonin syndrome?

Answer 8

Meperidine

Question 9

Which opioid should be avoided in patients with renal failure?

Answer 9

Meperidine and Morphine due to active metabolites excreted by the kidneys

Question 10

Which opioid is inhibited by Erythromycin?

Answer 10

Alfentanil

Question 11

If a patient is getting a liver transplant, which opioid would be best for that patient?

Answer 11

Remifentanil
*no metabolism in the liver