General receptors Flashcards
Major actions of alpha 1 receptors?
increase vascular smooth mm. contraction
increase pup dilator mm contraction
increase intestine/bladder sphincter contract
SYMPATHETIC
Major actions of alpha 2 receptors?
decrease sympathetic outflow decrease insulin release decrease lipolysis increases platelet aggregation SYMPATHETIC
Major action of B1 receptors?
increase
HR, contractility, renin, lipolysis
SYMPATHETIC
Major action of B2 receptors?
Vasodilator, bronchodilator
Increase HR, increase contractility,
increase lipolysis, increase insulin
ciliary mm relaxation
SYMPATHETIC
Major action of M1 receptors?
CNS, enteric nervous system
PSNS
Major action of M2 receptors?
decrease HR
decrease atria contractility
PSNS
Major action of M3 receptors?
increase exocrine gland secretion (lacrimal, salivary, gastric) increase peristalsis increase bladder contraction PSNS
M3 receptor effects on bronchioles?
bronchoconstriction
PSNS
M3 receptor effects on eye?
increase pupil sphincter contraction (miosis)
ciliary mm contraction (accomodation - near vision)
Effects of D1 receptors?
relax renal vascular smooth mm
Effects of D2 receptors?
Modulate transmitter release (think BRAIN!)
Effects of H1 receptors?
increase nasal and bronchial mucus
increase vascular permeability
contraction of bronchioles, puritis, pain
Effects of H2 receptors?
increases gastric acid secretion
Which receptors work via Gq and increase [Ca]?
H1 a1 V1 M1, M3 "HAVE1 M&M"
Which receptors work via cAMP?
“MAD 2’s”
M2
Alpha 2
D2
Presynaptic PSNS nerve releases what at terminal?
ACH!
Post synaptic PSNS receptors are ____ ?
nicotinic
Preganglionic sympathetics release _____ ?
ACh
Post ganglionic sympathetics release what at sweat gland synapses?
Ach
Post ganglionic sympathetics release ____ onto ___ and ___ receptors at the nerve ending?
NE onto alpha and beta receptors
think cardiac, smooth mm, gland cells, nerve term
Where is Dopamine released post synaptically?
sympathetic nerve terminals in
renal vasculature
smooth muscle
Nicotinic ACh receptors are all ________.
Ligand gated!
Muscarinic Ach receptors are _______ that act through ______.
Muscarinic Ach receptors are GPCRs that act through 2nd messengers.
