General Principles Of Pharmacokinetics

Question 0

What are the actions of the drug on the body? (Pharmacodynamics)

Answer 0

Therapeutic effects, side effects, toxic effects

Question 1

What are the actions of the body on the drug? (Pharmacokinetics)

Answer 1

Absorption, distribution, metabolism, excretion

Question 2

What is the concept of bioavailability?

Answer 2

The fraction or percentage of the drug dose that reaches systemic circulation. Determined from area under time vs. plasma concentration curve

Question 3

What are factors that determine blood levels of a drug?

Answer 3

Amount given, route of administration, rate and extent of absorption, distribution to tissues (sites or action and loss), rate and extent of metabolism, rate and extent of excretion

Question 4

What are the routes of drug administration?

Answer 4

Enteral (GI tract), paraenteral (injection), topical, inhalation, intraosseous

Question 5

What are types of enteral drug administration?

Answer 5

Oral (ingestion), sublingual, rectal suppositories

Question 6

What are types of paraenteral drug administration?

Answer 6

Intravenous, intramuscular, subcutaneous, intrathecal, epidural