General Principles of Infectious Disease Epidemiology and Control Flashcards

1
Q

Define Epidemiology

A

The study of the distribution and determinants of health related conditions in populations and how it is applied to the control of health problems

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2
Q

How do we calculate the prevalence of an infectious disease

A

number of infected/100,00

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3
Q

How do we calculate the incidence of an infectious disease

A

(# of infected/100,00)/ per annum

Prevalence/per annum

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4
Q

How do we calculate the standard mortality rate due to an infectious disease

A

(# of deaths/100,00)/per annum

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5
Q

Define R0

A

This is also known as the reproductive index which signifies the contagiousness or transmissibility of an infective agent.

When R0 < 1 its low
When R0 > 1 it is high

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6
Q

What is viral shedding?

A

This is the release of a viral illness from an infected person’s body into the environment by sneezing, coughing or speaking

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7
Q

What are the four steps in infection control?

A
  1. Data collection and quality
  2. Description of Infection
  3. Analysis of Infection
  4. Predictions and Planning
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8
Q

What are 5 sources of data collection in epidemiology

A
  1. Lab reports
  2. Clinical reports
  3. Death reports
  4. Surveillance
  5. Investigation
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9
Q

Why is the quality of data important and why would data from these sources be inaccurate?

A

The numbers may not always be accurate. From death certificates for example the death may not be caused by the infection being analyzed, additionally not all deaths come with a postmortem and the cause of death may not be known

Additionally with investigation, not everyone would be comfortable with health officials coming into their homes and conducting a thorough investigation

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10
Q

What are the three categories of description epidemiologists give to infections

A
  1. Definite
  2. Probable
  3. Possible/Suspected
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11
Q

Suspected infections come about from

A

no samples, they tend to be secondary infection after being in contact with a confirmed case

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12
Q

Probable infections are determined from

A

an indeterminate sources, the infection tends to be contracted in the hospital

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13
Q

Definite infections are determined from

A

A positive sample/source/case

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14
Q

Infections abide by the ‘equation’ below

Index case —–transmission——> Susceptible

The infection can be interrupted at any point.

What three ways can the index case be interrupted?

A

Prioritizing
- Case definition
- Effective treatment
- Isolation

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15
Q

Infections abide by the ‘equation’ below

Index case —–transmission——> Susceptible

The infection can be interrupted at any point.

What three ways can the transmission be interrupted?

A

Prioritize
- Understanding transmission routes
- Understanding how to control these transmission routes

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16
Q

Infections abide by the ‘equation’ below

Index case —–transmission——> Susceptible

The infection can be interrupted at any point.

What three ways can the susceptibles be protected

A

Prioritize

  • Isolation
  • Immunization
  • Chemoprophylaxis
17
Q

Define chemoprophylaxis

A

The administration of medication in order to prevent a disease

18
Q

The most successful infections have the two following traits

A
  1. numerous methods of transmission
  2. persistent pathogens (e.g MRSA and C.difficile are contracted in hospitals where the most intense hygienic practices would be thought to be.)
19
Q

What is a formite?

A

An object that spreads a disease

20
Q

What are the five methods of transmission

A
  1. Direct contact
  2. Formites
  3. aerosol
  4. Oral
  5. Vector borne
21
Q

Who constructed the first mathematical model to be used in epidemiology?

A

Bernoullini in 1760

22
Q

What is the purpose of mathematical models in epidemiology?

A

These are used in the planning stages of a possible epidemic to determine the probable severity of the infection using R0.

They help
-set priorities for research and determine gaps in knowledge

  • evaluate interventions previously used
23
Q

What are the two main things mathematical models in epidemiology should represent?

A
  1. Changes in the infection status of people in the population
  2. The movement patterns of the infection
24
Q

What is the aim of the planning stage?

A

To find a way to achieve R0<1

25
Q

Explain why infectious diseases are said to be successfully controlled when R0<1

A

When R0<1 is when there is sufficient herd immunity.

26
Q

How does R0 affect the herd immunity.

A

The higher the R0 value the higher percentage pf vaccine coverage is required for herd immunity

e.g The R0 for measles is 12-18 and the percentage vaccination for her immunity is 83%-94% while for mumps it is 4-7 and 75%-86% respectively