General Principles

Question 1

3 parameters for reviewing medications

Answer 1

QSE

Quality, safety, effectiveness

Question 2

Codral is

and what to watch out for

Answer 2

500mg paracetamol

5mg phenylephrine - alpha agonist decongestant, interacts with MAOi => palps, arrythymia, tremors

10mg dextromethorphan

2mg chlorpheniramine H1 blocker for funny nose

Question 3

indications for individualising therapy

Answer 3

1. active metabolite for renal impairment
2. hepatic impairment
3. single pathway metabolism for genetic polymorphism leading to reduced enzyme capacity
4. interactions