General Principles 2 Flashcards
1
Q
Cytochrome P 450 Inducers
A
PREG CBS Phenytion Rifampin Ehambutol Griseofulvin
Carbamazepine
Barbutuates
St. Johns wort
2
Q
CYP450 Inhibitors
A
SICK RAGE Q Sulfonamides Isoniazide Cimetidine Ketoconazole
Ritonavire Amiodarone Grapefruit juice Erythromycin Quinidine
3
Q
Route with 100% bioavailability
A
IV
4
Q
First pass effect
A
Oral
5
Q
Partial avoidance of first pass effect
A
Rectal
6
Q
Application to skin for local effect
A
Topical
7
Q
Application to skin for systemic effect
A
Transdermal
8
Q
Phase with small number of normal volunteers
A
Phase 1
9
Q
Post-marketing surveillance phase
A
Phase IV
10
Q
“Does it work with patients?”
A
Phase II
11
Q
Randomized, double blind, controlled studies
A
Phase III
12
Q
A drug for a rare disease
A
Orphan drug
